2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
- CAS No.
- 1429192-00-6
- Chemical Name:
- 2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone
- Synonyms
- Retro-2;RN 1-001;Retro-2 cycl;Retro-2 >=98% (HPLC);2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolin;2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone;4(1H)-Quinazolinone, 2,3-dihydro-2-(5-methyl-2-thienyl)-3-phenyl-;2-(5-methylthiophen-2-yl)-3-phenyl-2,3-dihydroquinazolin-4(1H)-one;Arenavirus,Human papillomavirus,Inhibitor,Retro-2 cycl,Virus Protease,Retro 2 cycl,Retro2 cycl,inhibit,HPV
- CBNumber:
- CB22751094
- Molecular Formula:
- C19H16N2OS
- Molecular Weight:
- 320.41
- MDL Number:
- MFCD28124399
- MOL File:
- 1429192-00-6.mol
- MSDS File:
- SDS
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P305+P351+P338-P332+P313-P337+P313-P362 |
| WGK Germany | 3 |
| HS Code | 2934999090 |
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone price More Price(15)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1085 | Retro-2 ≥98% (HPLC) | 1429192-00-6 | 5mg | $118 | 2024-03-01 | Buy |
| Sigma-Aldrich | SML1085 | Retro-2 ≥98% (HPLC) | 1429192-00-6 | 25mg | $498 | 2024-03-01 | Buy |
| Cayman Chemical | 21946 | Retro-2 ≥98% | 1429192-00-6 | 1mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 21946 | Retro-2 ≥98% | 1429192-00-6 | 5mg | $100 | 2024-03-01 | Buy |
| Cayman Chemical | 21946 | Retro-2 ≥98% | 1429192-00-6 | 10mg | $184 | 2024-03-01 | Buy |
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Chemical Properties,Uses,Production
Description
Retro-2 is a selective inhibitor of retrograde protein trafficking mediated by syntaxin-5 at the interface between the endosome and trans-Golgi network, with no discernable effects on other intracellular trafficking pathways. Retro-2 inhibits ebolavirus infection with an EC50 value of 12.2 μM and reduces ricin-induced toxicity by 2.7-fold when used at a concentration of 20 μM in HeLa cells. Retro-2 also blocks JC polyomavirus, BK polyomavirus, and SV40 infectivity in Vero green monkey kidney epithelial cells in vitro (EC50s = 28.4, 61.2, and 58.6 μM, respectively). In mouse models, Retro-2 improves survival and reduces symptoms following infection with Shiga toxin-producing E. coli when administered at a dose of 100 mg/kg and protects against ricin challenge when administered prophylactically at a dose of 2 mg/kg.
Uses
Retro-2 is an inhibitor of Ribosome-Inactivating Proteins (RIPs) as well as a blocker of Leishmania parasitophorous vacuoles (LPV) development.
Biochem/physiol Actions
Retro-2 is a non-toxic inhibitor of the endosome-to-Golgi retrograde transport that selectively protect cells from ricin, cholera toxin, and Shiga-like toxins, without affecting compartment morphology, endogenous retrograde cargos, or other trafficking steps.
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Preparation Products And Raw materials
Raw materials
Preparation Products
2,3-Dihydro-2-(5-methyl-2-thienyl)-3-phenyl-4(1H)-quinazolinone Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
| Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131981 | 58 |
| Adamas Reagent, Ltd. | 400-6009262 16621234537 | zhangsn@titansci.com | China | 14113 | 59 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghaizehan biopharma technology co., Ltd. | 021-61350663 13052117465 | sales@zehanbiopharma.com | China | 995 | 55 |
| Pharmacodia (Beijing) Co.,Ltd | +86-400-851-9921 | sales@pharmacodia.com | China | 2317 | 55 |
| Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9709 | 58 |
| Tianjin Kailiqi Biotechnology Co., Ltd. | 15076683720 | klq@cw-bio.com | China | 3412 | 55 |
| Beijing Solarbio Science & Tecnology Co., Ltd. | 010-50973130 4009686088 | 3193328036@qq.com | China | 29797 | 68 |