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PAROMOMYCIN SULFATE

PAROMOMYCIN SULFATE Structure
PAROMOMYCIN SULFATE structure
CAS No.
1263-89-4
Chemical Name:
PAROMOMYCIN SULFATE
Synonyms
PAROMOMYCIN SULPHATE;sulf;humatin;NEOMYCIN E;PAROMOMYCIN SULFATE SALT;Neomycin Sulfate EP Impurity E;O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate;fi5853;D00868;Humagel
CBNumber:
CB2278832
Molecular Formula:
C23H47N5O18S
Molecular Weight:
713.71
MDL Number:
MFCD00079278
MOL File:
1263-89-4.mol
MSDS File:
SDS
Last updated:2024-03-19 13:53:49
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PAROMOMYCIN SULFATE Properties

Melting point 145 °C (decomp)
alpha D25 +50.5° (c = 1.5 in water pH 6)
storage temp. Keep in dark place,Inert atmosphere,Room temperature
solubility H2O: 50 mg/mL store stock solution at 2-8°C. Stable at 37°C for 5 days.
form powder
color White to Off-White
Water Solubility Soluble in water
Merck 14,7041
BRN 5715182
Stability Hygroscopic
InChIKey LJRDOKAZOAKLDU-UDXJMMFXSA-N
CAS DataBase Reference 1263-89-4
FDA UNII 845NU6GJPS
NCI Drug Dictionary Humatin
EPA Substance Registry System Paromomycin sulfate (1263-89-4)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P280a-P304+P340-P305+P351+P338-P405-P501a
Hazard Codes  Xi
Risk Statements  23/24/25-36/38-39/23/24/25-61-36/37/38
Safety Statements  26-36/37-45-38-36
WGK Germany  2
RTECS  WK2320000
HS Code  2941901010
Toxicity LD50 in mice (mg/kg): ~15,000 orally; 700 s.c.; 110 i.v. (Di Marco, Bertazzoli)

PAROMOMYCIN SULFATE price More Price(48)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P5057 Paromomycin sulfate salt powder, BioReagent, suitable for cell culture, ≥98% 1263-89-4 1g $55.6 2024-03-01 Buy
Sigma-Aldrich 512731 Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem An aminoglycoside antibiotic containing 5 amino groups that exhibits antibacterial and antiamebic activity. 1263-89-4 5G $148 2022-05-15 Buy
TCI Chemical P2092 Paromomycin Sulfate >94.0%(HPLC) 1263-89-4 1g $57 2024-03-01 Buy
TCI Chemical P2092 Paromomycin Sulfate >94.0%(HPLC) 1263-89-4 5g $170 2024-03-01 Buy
Alfa Aesar J61274 Paromomycin sulfate 1263-89-4 1g $52.4 2024-03-01 Buy
Product number Packaging Price Buy
P5057 1g $55.6 Buy
512731 5G $148 Buy
P2092 1g $57 Buy
P2092 5g $170 Buy
J61274 1g $52.4 Buy

PAROMOMYCIN SULFATE Chemical Properties,Uses,Production

Description

Paromomycin was found in the culture broth of Streptomyces rimosus forma paromomycinus by Parke Davis & Co. in 1959. In the same year it was found in the culture broth of S. Crestomyceticus by Farmitalia and named amminosidin. Paromomycin is related structurally to neomycin, but it has a hydroxyl group at the 6 position, whereas neomycin has an amino group. Its antibacterial activity is weaker than that of neomycin, but its toxicity is much less. Paromomycin is used by intramuscular injection for therapy of respiratory, urinary, and surgical infections and by oral administration to treat dysentery and salmonellosis.

Chemical Properties

PAROMOMYCIN SULFATE is White to Off-White Solid

Uses

PAROMOMYCIN SULFATE is an aminogycoside antibiotic designed to fight intestinal infections such as cryptosporidiosis, amoebiasis, and leishmaniasis. Its antiprotozoal activity makes it an effecive histomonostatic feed addit ive in turkey poults experimentally infected with Histomonas meleagridis.

Uses

polymeric nonionic detergent

Uses

antibacterial, antiamebic

Definition

ChEBI: An aminoglycoside sulfate salt resulting from the treatment of paromomycin with sulfuric acid. A broad-spectrum antibiotic, it is used for the treatment of acute and chronic intestinal protozoal infections, but is not effective for extraintestinal protozoa infections. It is also used as a therapeutic against visceral leishmaniasis.

brand name

Humatin (King); Humatin (Parke- Davis).

General Description

Chemical structure: aminoglycoside

Biochem/physiol Actions

Paromomycin inhibits the initiation and elongation steps of protein synthesis by binding to 16S ribosomal RNA. Paramomycin binds to the A site, which causes defective polypeptide chains to be produced and leads to cell death.

Clinical Use

The isolation of paromomycin (Humatin) was reported in1956 from a fermentation with a Streptomyces sp. (PD04998), a strain said to resemble S. rimosus very closely.The parent organism had been obtained from soil samplescollected in Colombia. Paromomycin, however, moreclosely resembles neomycin and streptomycin in antibioticactivity than it does oxytetracycline, the antibiotic obtainedfrom S. rimosus.
Paromomycin has broad-spectrum antibacterial activityand has been used for the treatment of GI infections causedby Salmonella and Shigella spp., and enteropathogenic E.coli. Currently, however, its use is restricted largely to thetreatment of intestinal amebiasis. Paromomycin is soluble inwater and stable to heat over a wide pH range.

Safety Profile

Poison by intravenous,subcutaneous, and intramuscular routes. Mildly toxic byingestion. Mutation data reported. When heated to decomposition it emits very toxic fumesof SOx and NOx.

Purification Methods

Purify it by dissolving it in H2O (0.5g/10mL) and adding excess EtOH, filter or collect and wash with EtOH, then Et2O by centrifugation, and dry it in vacuo. An aqueous solution is stable at 37o for a week but longer at 0-5o. The free base [7542-37-2] is a white amorphous powder which should be stored under N2 because it is strongly basic and can absorb CO2 from the atmosphere. It is soluble in MeOH (less soluble in EtOH) and has [] D 25 +65o (c 1.5, MeOH). It is an antimicrobial against Gram +ve and Gram –ve bacteria and is antiamoebic. It inhibits initiation and peptide elongation during protein synthesis. [Haskell et al. J Am Chem Soc 8 1 , 3480, 3482 1959, Hichens & Rinehart J Am Chem Soc 85 1547 1963, Beilstein 18 III/IV 7534.]

PAROMOMYCIN SULFATE Preparation Products And Raw materials

Raw materials

Preparation Products

PAROMOMYCIN SULFATE Suppliers

Global( 344)Suppliers
Supplier Tel Email Country ProdList Advantage
Shaanxi Dideu Medichem Co. Ltd 		+86-029-81138252 +86-18789408387 1057@dideu.com China 3537 58
Hebei Mojin Biotechnology Co., Ltd 		+8613288715578 sales@hbmojin.com China 12456 58
Hebei Yanxi Chemical Co., Ltd. 		+8617531190177 peter@yan-xi.com China 5993 58
Shanghai Affida new material science and technology center 		+undefined15081010295 2691956269@qq.com China 359 58
Hangzhou FandaChem Co.,Ltd. 		008657128800458; +8615858145714 fandachem@gmail.com China 9348 55
career henan chemical co 		+86-0371-86658258 sales@coreychem.com China 29914 58
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Hebei Guanlang Biotechnology Co., Ltd. 		+86-19930503282 alice@crovellbio.com China 8823 58
Xiamen AmoyChem Co., Ltd 		+86-592-6051114 +8618959220845 sales@amoychem.com China 6387 58
HubeiwidelychemicaltechnologyCo.,Ltd 		18627774460 faith@widelychemical.com CHINA 742 58
Supplier Advantage
Shaanxi Dideu Medichem Co. Ltd 		58
Hebei Mojin Biotechnology Co., Ltd 		58
Hebei Yanxi Chemical Co., Ltd. 		58
Shanghai Affida new material science and technology center 		58
Hangzhou FandaChem Co.,Ltd. 		55
career henan chemical co 		58
Hubei Jusheng Technology Co.,Ltd. 		58
Hebei Guanlang Biotechnology Co., Ltd. 		58
Xiamen AmoyChem Co., Ltd 		58
HubeiwidelychemicaltechnologyCo.,Ltd 		58

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View Lastest Price from PAROMOMYCIN SULFATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Paromomycin Sulfate pictures 2024-03-19 Paromomycin Sulfate
1263-89-4
 US $0.00-0.00 / KG 1KG 99 10 tons Shanghai Affida new material science and technology center
Paromomycin Sulfate pictures 2024-03-16 Paromomycin Sulfate
1263-89-4
 US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
Paromomycin Sulfate pictures 2023-11-04 Paromomycin Sulfate
1263-89-4
 US $1.00 / KG 1KG 99% 10000KG Shaanxi Dideu Medichem Co. Ltd
  • Paromomycin Sulfate pictures
  • Paromomycin Sulfate
    1263-89-4
  • US $0.00-0.00 / KG
  • 99
  • Shanghai Affida new material science and technology center

PAROMOMYCIN SULFATE Spectrum

PAROMOMYCIN SULFATE(1263-89-4)1HNMR

1263-89-4(PAROMOMYCIN SULFATE)Related Search:

Nitazoxanide Spiramycin Rimonabant Ribostamycin sulfate SPECTINOMYCIN DIHYDROCHLORIDE
(R)-2-Aminocyclohenanol Glucosamine sulfate PAROMOMYCIN SULFATE C-(TETRAHYDRO-PYRAN-2-YL)-METHYLAMINE HYDROCHLORIDE paromomycin
5-Deoxy-D-ribose Methyl beta-D-ribofuranoside TRANS-2-AMINOCYCLOHEXANOL HYDROCHLORIDE 3-BUTOXY-PROPIONALDEHYDE DIETHYL ACETAL 3-Amino-cyclohexanol
{PAROMOMYCIN SULFATE--N/H PAROMOMYCIN SULFATE USP(CRM STANDARD) PAROMOMYCIN SULFATE WHO(CRM STANDARD)

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PAROMOMYCIN SULFATE aminosidinesulfate aminosidinesulphate aminosidinsulfate fi5853 gabbroral D-Streptamine, O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-O-b-D-ribofuranosyl-(15)-O-[2-amino-2-deoxy-a-D-glucopyranosyl-(14)]-2-deoxy-, sulfate (salt) (8CI) D-Streptamine, O-2-amino-2-deoxy-a-D-glucopyranosyl-(14)-O-[O-2,6-diamino-2,6-dideoxy-b-L-idopyranosyl-(13)-b-D-ribofuranosyl-(15)]-2-deoxy-, sulfate (salt) (9CI) Farmiglucin Farminosidin Humagel Paramicina Pargonyl Paricina Sinosid Paromomycin Sufate D00868 Humatin (tn) Paromomycin sulfate (jan/usp) Paromomycin sulfate ,98% Paromomycin Sulfate (125 mg) PayoMoMycin Sulfate O-2,6-DiaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-aMino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-D-StreptaMine Sulfate humycinsulfate streptamine,o-2,6-diamino-2,6-dideoxy-beta-l-idopyranosyl-(1-3)-o-beta-d-ribof paromomycin sulfate cell culture tested paromomycin sulfate plant cell*culture tested paromomycin sulphates D-Streptamine, O-2,6-diamino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-O-β-D-ribofuranosyl-(1→5)-O-[2-amino-2-deoxy-α-D-glucopyranosyl-(1→4)]-2-deoxy-, sulfate (1:1) Barone sulfate kanamycin Solution, 100ppm PAROMOMYCIN SULFATE CELL CULTURE REAGENT 97+% PAROMOMYCIN SULFATE USP 97+% Paramomycinsulfate 1600 Antibiotic Aminosidin sulphate Aminoxidin O-2-AMino-2-deoxy-α-D-glucopyranosyl-(1→4)-O-[O-2,6-diaMino-2,6-dideoxy-β-L-idopyranosyl-(1→3)-β-D-ribofuranosyl-(1→5)]-2-deoxy-D-streptaMine Sulfate Paromomycin sulphate solution,1000ppm solution Paromomycin sulphate solution,100ppm Paromomycin Sulfate - CAS 1263-89-4 - Calbiochem Framycetin EP Impurity E Paromomycin Sulfate > PAROMOMYCIN SULFATE USP/EP/BP Paromomycin Sulfater Framycetin sulfate EP Impurity E (2S,3S,4R,5R,6R)-5-Amino-2-(aminomethyl)-6-(((2R,3S,4R,5S)-5-(((1R,2R,3S,5R,6S)-3,5-diamino-2-(((2S,3R,4R,5S,6R)-3-amino-4,5-dihydroxy-6-(hydroxymethyl)tetrahydro-2H-pyran-2-yl)oxy)-6-hydroxycyclohexyl)oxy)-4-hydroxy-2-(hydroxymethyl)tetrahydrofuran-3-yl)oxy)tetrahydro-2H-pyran-3,4-diol sulfate(1:x) Paromomycin Sulfate (PRM) Paromomycin Sulfate (1500003) O - 2, 6 - Diamino - 2, 6 - dideoxy - b - L - idopyranosyl - (1,3) - O - b - D - ribofuranosyl - (1,5) - O - [2 - amino - 2 - deoxy - a - D - glucopyranosyl - (1,4) ] - 2 - deoxy - streptamine sulfate humatin sulf Neomycin Sulfate EP Impurity E PAROMOMYCIN SULPHATE PAROMOMYCIN SULFATE SALT NEOMYCIN E Paromomycine sulphate Sparsentan Impurity 29 Baromycin sulfate