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(-)-FENCHONE

(-)-FENCHONE
(-)-FENCHONE structure
CAS No.
7787-20-4
Chemical Name:
(-)-FENCHONE
Synonyms
FENCHONE;L-FENCHONE;(-)-FENCHONE;L(-)-FENCHONE;ALPHA-FENCHONE;FENCHONE, (-)-;L-ALPHA-FENCHONE;(1R,4S)-fenchone;L-FENCHONE 98+%;(1R)-(-)-FENCHONE
CBNumber:
CB2283113
Molecular Formula:
C10H16O
Formula Weight:
152.23
MOL File:
7787-20-4.mol

(-)-FENCHONE Properties

Melting point:
5-6 °C(lit.)
alpha 
[α]D20 -50~-60° (c=4, C2H5OH)
Boiling point:
192-194 °C(lit.)
Density 
0.948 g/mL at 25 °C(lit.)
refractive index 
n20/D 1.461(lit.)
FEMA 
4519 | L-FENCHONE
Flash point:
127 °F
storage temp. 
Flammables area
form 
Liquid
color 
Clear colorless to light yellow
optical activity
[α]24/D 50.5°, neat
JECFA Number
2200
BRN 
2042710
CAS DataBase Reference
7787-20-4(CAS DataBase Reference)
Substances Added to Food (formerly EAFUS)
L-FENCHONE
EWG's Food Scores
1
EPA Substance Registry System
Bicyclo[2.2.1]heptan-2-one, 1,3,3-trimethyl-, (1R,4S)- (7787-20-4)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS02
Signal word  Warning
Hazard statements  H227-H226
Precautionary statements  P233-P240-P241+P242+P243-P280-P303+P361+P353-P403+P235-P501-P210-P370+P378-P210e-P280a-P370+P378a-P501a
Risk Statements  10
Safety Statements  23-24/25
RIDADR  UN 1224 3/PG 3
WGK Germany  3
RTECS  RB7875000
TSCA  Yes
HazardClass  3
PackingGroup  III
HS Code  29142900
Toxicity The acute oral LD50 value in rats was reported as 616 g/kg (Jenner, Hagan, Taylor. Cook & Fitzhugh, 1964) and the acute dermal LD50 value in rabbits exceeded 5 g/kg (Leven-stein, 1975).

(-)-FENCHONE price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 196436 (1R)-(?)-Fenchone ≥98% 7787-20-4 50g $40.9 2019-12-02 Buy
Sigma-Aldrich 92101 (?)-Fenchone analytical standard 7787-20-4 50mg $55.8 2019-12-02 Buy
TCI Chemical F0164 (-)-Fenchone >98.0%(GC) 7787-20-4 25mL $22 2020-06-24 Buy
TCI Chemical F0164 (-)-Fenchone >98.0%(GC) 7787-20-4 500mL $168 2020-06-24 Buy
Alfa Aesar L15151 (-)-Fenchone, 98+% 7787-20-4 250g $75 2020-06-24 Buy

(-)-FENCHONE Chemical Properties,Uses,Production

Chemical Properties

CLEAR COLOURLESS TO SLIGHTLY YELLOW LIQUID

Occurrence

Reported to be found in many essential oils, including those of Thuja plicata, T.occiden-talis, T.standi shii, Russian anise, fennel, a few Artemisia varieties (A. frigida, A . verlotorum and A . santolinaefolia), Lavandula stoechas and L. burmannii. The highest levels (12-19%) are found in fennel oil (Fenarolis Handbook of Flavor Ingredients, 1975; Gildemeister & Hoffman, 1963).

Uses

Flavoring.

Definition

ChEBI: A fenchone that has (1R,4S)-stereochemistry. It is a constituent of the essential oils obtained from fennel.

Preparation

By isolation from cedar leaf oil (Thuja oil) or by various synthetic methods (Arctander, 1969).

Pharmacology

In mice, fenchone injected sc in sesame oil produced clonic convulsions at non-lethal doses, with a median convulsive dose (CD50) of 1133 mg/kg, and a dose of 500 mg/kg given sc was an effective arousal agent, reducing the hexobarbitone sleep time (Wenzel & Ross, 1957). In rats, an ip dose of 500 mg/kg had no effect on pentobarbitone-depressed respiration, while ip doses of 50-400 mg/kg increased running activity but did not affect total activity (Wenzel & Ross, 1957). Fenchone showed some antispasmodic action on excised mouse intestine (Haginiwa, Harada & Morishita, 1963), and at 260 mmol/kg showed good choleretic properties of moderately long duration when given orally in olive oil to rats (M?rsdorf, 1966). Thomas (1958) reported that it acted as a central nervous system stimulant. Fenchone has been used medically as a counter-irritant (Merck Index, 1968).

Metabolism

Rimini (1901 & 1909) showed that, in the dog, fenchone was probably oxidized to 4-hydroxyfenchone. Reinartz & Zanke (1936) showed that there were other products. They separated, as lead salts, the glucuronides from the urine of dogs receiving d-fenchone. The lead was removed with sulphuric acid and the resulting solution was hydrolysed. In the resulting mixture of hydroxyfen chones, the presence of 4- and 5-hydroxyfenchones and 7r-apofenchone-3-carboxylic acid was demon strated (Williams, 1959).

Purification Methods

Purification is as for the (+)-enantiomer above and should have the same physical properties except for opposite optical rotations. UV has max 285nm ( 12.29). [Braun & Jacob Chem Ber 66 1461 1933, UV: Ohloff et al. Chem Ber 90 106 1957.] [Beilstein 7 III 392, 7 IV 212.]

(-)-FENCHONE Preparation Products And Raw materials

Raw materials

Preparation Products


(-)-FENCHONE Suppliers

Global( 91)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
BOC Sciences
1-631-619-7922
1-631-614-7828 inquiry@bocsci.com United States 20039 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 35434 58
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1853 58
Shaanxi Dideu Medichem Co. Ltd
+86-15319487004
+86-29-88380327 1015@dideu.com CHINA 3526 58
Zhuozhou Wenxi import and Export Co., Ltd
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+8613111626072 zzwenxi@126.com CHINA 7497 58
Wuhan ChemNorm Biotech Co.,Ltd.
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Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32444 55

View Lastest Price from (-)-FENCHONE manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2020-05-25 (-)-Fenchone
7787-20-4
US $0.00 / ml 0.1ml GC≥98% 100 ml Shanghai Standard Technology Co., Ltd.
2020-01-19 Fenchone
7787-20-4
US $0.00-0.00 / KG 100g 99.0%+ 100 tons Shaanxi Dideu Medichem Co. Ltd
2018-12-24 (-)-FENCHONE
7787-20-4
US $1.00 / kg 1g 99% 100KG career henan chemical co

(-)-FENCHONE Spectrum


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