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beta-Diphosphopyridine nucleotide

beta-Diphosphopyridine nucleotide
beta-Diphosphopyridine nucleotide structure
CAS No.
53-84-9
Chemical Name:
beta-Diphosphopyridine nucleotide
Synonyms
DPN;NAD;B-NAD;β-DPN;β-NAD;eotide;Nad.Dpn;beta-DPN;beta-NAD;enzopride
CBNumber:
CB2286280
Molecular Formula:
C21H27N7O14P2
Formula Weight:
663.43
MOL File:
53-84-9.mol

beta-Diphosphopyridine nucleotide Properties

Melting point:
140-142 °C (decomp)
alpha 
D20 -31.5° (c = 1.2 in water)
storage temp. 
-20°C
solubility 
H2O: 50 mg/mL
form 
Powder
color 
White
PH
~3.0 (50mg/mL in water)
Odor
Odorless
Water Solubility 
Soluble in water at 50mg/ml
Merck 
14,6344
BRN 
3584133
Stability:
Stable. Hygroscopic. Incompatible with strong oxidizing agents.
InChIKey
BAWFJGJZGIEFAR-WWRWIPRPSA-N
EPA Substance Registry System
Adenosine 5'-(trihydrogen diphosphate), P'.fwdarw.5'-ester with 3-(aminocarbonyl)-1-.beta.-D-ribofuranosylpyridinium, inner salt (53-84-9)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Warning
Hazard statements  H371
Precautionary statements  P260
Hazard Codes  Xn,F,Xi
Risk Statements  36-68/20/21/22-20/21/22-40-22
Safety Statements  36-26-36/37-24/25
WGK Germany  3
RTECS  UU3450000
TSCA  Yes
HS Code  29349990

beta-Diphosphopyridine nucleotide price More Price(55)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich NAD98-RO NAD Grade II, free acid 53-84-9 1 g $67.6 2021-03-22 Buy
Sigma-Aldrich 43410 β-Nicotinamide adenine dinucleotide hydrate ≥95% (HPLC) 53-84-9 1g $92.9 2021-03-22 Buy
Sigma-Aldrich NAD100-RO NAD Grade I, free acid 53-84-9 1 g $111 2021-03-22 Buy
Sigma-Aldrich N8285 β-Nicotinamide adenine dinucleotide pkg of 10?mg (per vial) 53-84-9 15 vials $201 2021-03-22 Buy
Sigma-Aldrich N8410 β-Nicotinamide adenine dinucleotide pkg of 20?mg (per vial) 53-84-9 15 vials $207 2021-03-22 Buy

beta-Diphosphopyridine nucleotide Chemical Properties,Uses,Production

Chemical Properties

Beta-NICOTINAMIDE ADENINE DINUCLEOTIDE is Hygroscopic white powder.

Uses

antidepressant, oxytocic

Uses

β-Nicotinamide Adenine Dinucleotide is a coeznyme consisting of an adenine base and a nicotinamide base connected by a pair of bridging phosphate group. β-Nicotinamide Adenine Dinucleotide acts as a c oenzyme in redox reactions, as a donor of ADP-ribose moieties in ADP-ribosylation reactions and also as a precursor of the second messenger molecule cyclic ADP-ribose. β-Nicotinamide Adenine Dinucleot ide also acts as a substrate for bacterial DNA ligases and a group of enzymes called sirtuins that use NAD+ to remove acetyl groups from proteins.

Definition

The oxidized form of β-Nicotinamide Adenine Dinucleotide. It exists as an anion under normal physio-logic conditions.

Purification Methods

NAD is purified by paper chromatography or better on a Dowex-1 ion-exchange resin. The column is prepared by washing with 3M HCl until free of material absorbing at 260nm, then with water, 2M sodium formate until free of chloride ions and, finally, with water. NAD, as a 0.2% solution in water, is adjusted with NaOH to pH 8, and adsorbed onto the column, washed with water, and eluted with 0.1M formic acid. Fractions with strong absorption at 360nm are combined, acidified to pH 2.0 with 2M HCl, and cold acetone (ca 5L/g of NAD) is added slowly and with constant agitation. It is left overnight in the cold, then the precipitate is collected in a centrifuge, washed with pure acetone and dried under vacuum over CaCl2 and paraffin wax shavings [Kornberg Methods Enzymol 3 876 1957]. It has been purified by anion-exchange chromatography [Dalziel & Dickinson Biochemical Preparations 11 84 1966.] The purity is checked by reduction to NADH (with EtOH and yeast alcohol dehydrogenase) which has 340mn 6220 M-1cm-1. [Todd et al. J Chem Soc 3727, 3733 1957.] [pKa, Lamborg et al. J Biol Chem 231 685 1958.] The free acid crystallises from aqueous Me2CO with 3H2O and has m 140-142o. It is stable in cold neutral aqueous solutions in a desiccator (CaCl2) at 25o, but decomposes at strong acid and alkaline pH. Its purity is checked by reduction with yeast alcohol dehydrogenase and EtOH to NADH and noting the OD at 340nm. Pure NADH (see below) has 340 6.2 x 104 M-1cm-1, i.e. 0.1mole of NADH in 3mL and in a 1cm path length cell has an OD at 340nm of 0.207. [Beilstein 26 IV 3644.]

beta-Diphosphopyridine nucleotide Preparation Products And Raw materials

Raw materials

Preparation Products


beta-Diphosphopyridine nucleotide Suppliers

Global( 472)Suppliers
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Bontac Bio-engineering (Shenzhen) Co., Ltd
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View Lastest Price from beta-Diphosphopyridine nucleotide manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-11-30 β-nicotinamide adenine dinucleotide (oxidized form)
53-84-9
US $0.00 / g 10g 98% 100 tons Bontac Bio-engineering (Shenzhen) Co., Ltd
2021-11-29 beta-Diphosphopyridine nucleotide
53-84-9
US $10.00 / KG 1KG 99.9% 20 tons/month Shanxi Lianxu New Material Co., LTD
2021-11-26 NAD+
53-84-9
US $11.90 / KG 1KG 99% 10kg Hong Kong Tiansheng New Material Trading Co., Ltd

beta-Diphosphopyridine nucleotide Spectrum


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