4-Carboxylphenylboronic acid pinacol ester
- CAS No.
- 180516-87-4
- Chemical Name:
- 4-Carboxylphenylboronic acid pinacol ester
- Synonyms
- 4-(4,4,5,5-TETRAMETHYL-1,3,2-DIOXABOROLAN-2-YL)BENZOIC ACID;4-CARBOXYPHENYLBORONIC ACID PINACOLATE;4-CARBOXYPHENYLBORONIC ACID PINACOL ESRER;4-carboxylphenylboronic acid pinacol ester;4-CARBOXYPHENYLBORONIC ACID, PINACOL ESTER;4-Carboxybenzeneboronic acid pinacol ester;4-Carboxylphenylboronic acid pinacol ester 97%;4-Carboxybenzeneboronic acid pinacol ester, 97%;4-Carboxybenzeneboronic acid, pinacol ester 98%;4-CARBOXYBENZENEBORONIC ACID PINACOL CYCLIC ESTER
- CBNumber:
- CB2288259
- Molecular Formula:
- C13H17BO4
- Molecular Weight:
- 248.08
- MDL Number:
- MFCD01863710
- MOL File:
- 180516-87-4.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| 4-Carboxylphenylboronic acid pinacol ester 97% | 513490 | 5g | $38.8 |
| 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid >98.0%(GC)(T) | T2841 | 1g | $32 |
| 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% min.97% | 05-1037 | 1g | $48 |
| 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% min.97% | 05-1037 | 5g | $181 |
| 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% | 05-1037 | 1g | $44 |
| More product size | |||
| Melting point | 228-231 °C(lit.) |
|---|---|
| Boiling point | 379.7±25.0 °C(Predicted) |
| Density | 1.15±0.1 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| pka | 4.09±0.10(Predicted) |
| form | Crystalline Powder |
| color | White |
| Water Solubility | Insoluble |
| InChI | InChI=1S/C13H17BO4/c1-12(2)13(3,4)18-14(17-12)10-7-5-9(6-8-10)11(15)16/h5-8H,1-4H3,(H,15,16) |
| InChIKey | IYDKBQIEOBXLTP-UHFFFAOYSA-N |
| SMILES | C(O)(=O)C1=CC=C(B2OC(C)(C)C(C)(C)O2)C=C1 |
| CAS DataBase Reference | 180516-87-4(CAS DataBase Reference) |
| UNSPSC Code | 12352103 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P261-P305+P351+P338 | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36-26 | |||||||||
| WGK Germany | 3 | |||||||||
| HazardClass | IRRITANT | |||||||||
| HS Code | 29163990 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| NFPA 704 |
|
4-Carboxylphenylboronic acid pinacol ester price More Price(56)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 513490 | 4-Carboxylphenylboronic acid pinacol ester 97% | 180516-87-4 | 5g | $38.8 | 2026-04-30 | Buy |
| TCI Chemical | T2841 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic Acid >98.0%(GC)(T) | 180516-87-4 | 1g | $32 | 2026-04-30 | Buy |
| Strem Chemicals | 05-1037 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% min.97% | 180516-87-4 | 1g | $48 | 2026-04-30 | Buy |
| Strem Chemicals | 05-1037 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% min.97% | 180516-87-4 | 5g | $181 | 2026-04-30 | Buy |
| Strem Chemicals | 05-1037 | 4-(4,4,5,5-Tetramethyl-1,3,2-dioxaborolan-2-yl)benzoic acid, min. 97% | 180516-87-4 | 1g | $44 | 2024-03-01 | Buy |
4-Carboxylphenylboronic acid pinacol ester Chemical Properties,Uses,Production
Chemical Properties
white crystalline powder
Uses
4-Carboxybenzeneboronic acid pinacol ester is used to improvement of transition metal-mediated carbon-carbon as well as carbon-heteroatom cross-coupling reactions as a labeling feature with the focus on the preparation of radio labeled compounds for molecular imaging.
Synthesis
150-13-0
73183-34-3
180516-87-4
GENERAL METHODS: Tert-butyl nitrite (155 mg, 1.1 mmol) was added dropwise to a mixture containing bis(pinacolato)diboron (127 mg, 0.5 mmol), p-aminobenzoic acid (61 mg, 0.5 mmol) and eosin Y (0.01 mmol). The reaction mixture was stirred in acetonitrile (3 mL) under blue LED irradiation for 2 h at room temperature (the progress of the reaction was monitored by TLC). Upon completion of the reaction, the mixture was diluted with ethyl acetate (5 mL) and then filtered through diatomaceous earth. The filtrate was extracted with ethyl acetate (3 x 10 mL) and the combined organic phases were washed with saturated saline and dried over anhydrous Na2SO4. Concentration under reduced pressure afforded the crude product, which was purified by silica gel column chromatography using hexane-ethyl acetate (98:2) as eluent to afford pure 4-carboxyphenylboronic acid pinacol ester as a pale yellow viscous liquid (208 mg, 88% yield).IR (pure samples)2978, 2933, 2839, 2526, 2050, 1950, 1911, 1724, 1605, 1570 cm-1; 1H NMR (500 MHz, CDCl3) δ 1.33 (s, 12H), 7.82 (s, 3H), 6.89 (d, J = 8.0 Hz, 2H), 7.75 (d, J = 8.0 Hz, 2H); 13C NMR (125 MHz, CDCl3) δ 24.9 (4C), 55.2, 83.6 (2C), 113.4 (2C), 136.6 (2C), 162.3.The spectral data of the obtained compounds are in agreement with the 4-carboxyphenylboronic acid pinacol ester reported in the literature.
References
[1] Synlett, 2012, vol. 23, # 9, p. 1394 - 1396
[2] Tetrahedron Letters, 2016, vol. 57, # 14, p. 1551 - 1554
[3] Journal of Organic Chemistry, 2013, vol. 78, # 5, p. 1923 - 1933
4-Carboxylphenylboronic acid pinacol ester Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co Ltd | +86-16264648883 | niki@zlchemi.com | China | 7245 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29640 | 60 |
| Shanghai Daken Advanced Materials Co.,Ltd | +86-2158073036 | info@dakenam.com | China | 13903 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 33024 | 60 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29817 | 58 |
| HaBo Hong Kong Co., Limited. | +86-25-18512596065 | info@habotech.com | CHINA | 933 | 58 |
| Jinan Finer Chemical Co., Ltd | +86-531-88989536 +86-15508631887 | sales@finerchem.com | China | 2949 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
View Lastest Price from 4-Carboxylphenylboronic acid pinacol ester manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-06-27 | 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
|
US $0.00 / KG | 1KG | 99% | 500000kg | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-05-23 | 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
|
US $10.00 / kg | 1kg | 99% | 20 ton | Hebei Zhuanglai Chemical Trading Co Ltd | |
 |
2021-07-13 | 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
|
US $15.00-10.00 / KG | 1KG | 99%+ HPLC | Monthly supply of 1 ton | Zhuozhou Wenxi import and Export Co., Ltd |
-
- 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
- US $0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
- US $10.00 / kg
- 99%
- Hebei Zhuanglai Chemical Trading Co Ltd
-
- 4-Carboxylphenylboronic acid pinacol ester
180516-87-4
- US $15.00-10.00 / KG
- 99%+ HPLC
- Zhuozhou Wenxi import and Export Co., Ltd
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