5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- CAS No.
- 78606-80-1
- Chemical Name:
- 5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER
- Synonyms
- BML-111;BML111,BML 111;6(R)-7-trihydroxymethyl Heptanoate;1,3-Benzodioxole-9-sulfonylchloride;(5S,6R)-METHYL 5,6,7-TRIHYDROXYHEPTANOATE;5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER;5(S),6(R)-trihydroxy-7-heptanoic acid, methyl ester;Heptanoic acid, 5,6,7-trihydroxy-, methyl ester, (5S,6R)-
- CBNumber:
- CB2296632
- Molecular Formula:
- C8H16O5
- Molecular Weight:
- 192.21
- MDL Number:
- MFCD00211214
- MOL File:
- Mol file
- MSDS File:
- SDS
| Boiling point | 360.8±42.0 °C(Predicted) |
|---|---|
| Density | 1?+-.0.06 g/cm3(Predicted) |
| storage temp. | -20°C |
| solubility | H2O: ≥20mg/mL |
| pka | 13.74±0.20(Predicted) |
| form | powder |
| color | white to beige |
| Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months. |
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER price More Price(11)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML0215 | 5(S),6(R),7-Trihydroxyheptanoic acid methyl ester ≥98% (HPLC) | 78606-80-1 | 25mg | $560 | 2022-05-15 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 1mg | $57 | 2024-03-01 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 5mg | $249 | 2024-03-01 | Buy |
| Cayman Chemical | 10005032 | 5(S),6(R)-7-trihydroxymethyl Heptanoate ≥95% | 78606-80-1 | 10mg | $437 | 2024-03-01 | Buy |
| Tocris | 5488 | BML111 | 78606-80-1 | 10 | $182 | 2021-12-16 | Buy |
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Chemical Properties,Uses,Production
Description
BML-111 (78606-80-1) novel truncated analog of lipoxin A4 which retains anti-inflammatory activity.1 Inhibits LTB4-induced leukocyte chemotaxis, IC50=5 nM).1 Attenuates hemorrhagic shock-induced acute lung injury in a rat model.2 Displays hepatoprotective effects in acetaminophen-induced liver injury in mice.3 Limits inflammatory damage in the cerebral cortex and helps maintain blood brain barrier integrity in a rat model of ischemic stroke.4 Attenuates renal ischemia/reperfusion injury via activation of p38 MAPK/PPARa/HO-1 pathway.5
Uses
5(S),6(R)-7-trihydroxymethyl Heptanoate is a potent lipoxin A4 agonist.
storage
Store at -20°C
References
1) Lee et al. (1991), Inhibition of leukotriene B4-induced neutrophil migration by lipoxin A4: structure-function relationships; Biochem. Biophys. Res. Commun., 180 1416 2) Li et al. (2013), BML-111 attenuates hemorrhagic shock-induced acute lung injury through inhibiting activation of mitogen-activated protein kinase pathway in rats; J. Surg. Res., 183 710 3) El-Agamy et al. (2014), Protective effects of BML-111 against acetaminophen-induced acute liver injury in mice; J. Physiol. Biochem., 70 141 4) Hawkins et al. (2014), Neurovascular protection by post-ischemic intravenous injections of the lipoxin A4 receptor agonist, BML-111, in a rat model of ischemic stroke; J. Neurochem., 129 130 5) Wu et al. (2016), BML-111-Attenuates renal Ischemia/Reperfusion Injury via Peroxisome Proliferator-Activates Receptor-α-Regulated Heme Oxygenase-1; Inflammation, 39 611
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Preparation Products And Raw materials
Raw materials
Preparation Products
5(S),6(R),7-TRIHYDROXYHEPTANOIC ACID, METHYL ESTER Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Alfa Chemistry | +1-5166625404 | Info@alfa-chemistry.com | United States | 21317 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| Wuhan Topule Biopharmaceutical Co., Ltd | +8618327326525 | masar@topule.com | China | 8474 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Guangzhou Isun Pharmaceutical Co., Ltd | 020-39119399 18927568969 | isunpharm@qq.com | China | 4428 | 55 |
| DebyeTec.com Inc. | 18086626237 18086626237 | sales@debyesci.com | China | 2643 | 56 |
| Alfa Chemistry | 1-516-6625404 | support@alfa-chemistry.com | United States | 9171 | 60 |
| ATK CHEMICAL COMPANY LIMITED | 3429815786 13301662590 | sales@atkchemical.com | China | 10006 | 55 |