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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine structure

CAS No.: 300543-56-0

Chemical Name:: (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine

Synonyms: Levocetirizine Impurity A;Levocetirizine Impurity 2;(R)-Cetirizine EP Impurity A;(R)-1-[(4-Chlorophenyl)phenylmethyl;(R)-1-(p-Chlorobenzhydryl)piperazine;Chlorobenzhydryl Piperazine (F02160);(R)-N-(4-Chlorobenzyl hydryl) piperazine;R(-)-1-[(4-Chlorophenyl)benzyl]piperazine;(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE;(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine

CBNumber:: CB2299774

Molecular Formula:: C17H19ClN2

Molecular Weight:: 286.8

MDL Number:: MFCD11519277

MOL File:: 300543-56-0.mol

MSDS File:: SDS

Last updated:2024-03-05 11:58:23

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(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Properties

Melting point	91-93oC
Boiling point	409.1±0.0 °C(Predicted)
Density	1.158
storage temp.	Keep in dark place,Inert atmosphere,Room temperature
solubility	Chloroform (Slightly), Dichloromethane (Slightly), Methanol (Slightly)
pka	8.99±0.10(Predicted)
form	Solid
color	White
PH	9.38 at 25℃ and 10.07g/L
Water Solubility	Soluble in chloroform, methanol, and dichloromethane. Slightly soluble in water.
InChI	InChI=1/C17H19ClN2/c18-16-8-6-15(7-9-16)17(14-4-2-1-3-5-14)20-12-10-19-11-13-20/h1-9,17,19H,10-13H2/t17-/s3
InChIKey	UZKBSZSTDQSMDR-SCBJWRGWNA-N
SMILES	[C@@H](N1CCNCC1)(C1C=CC=CC=1)C1C=CC(Cl)=CC=1 \|&1:0,r\|
CAS DataBase Reference	300543-56-0
FDA UNII	890A9G29PG

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H315-H319-H335

Precautionary statements

P261-P280a-P304+P340-P305+P351+P338-P405-P501a

HS Code

2933599550

NFPA 704

	1
2		0

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Alfa Aesar	H63722	(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%	300543-56-0	5g	$424.65	2024-03-01	Buy
Alfa Aesar	H63722	(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%	300543-56-0	1g	$99.9	2023-06-20	Buy
Alfa Aesar	H63722	(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine, 97%	300543-56-0	250mg	$33.2	2023-06-20	Buy
TRC	C379574	(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine	300543-56-0	25mg	$120	2021-12-16	Buy
Matrix Scientific	089223	(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine	300543-56-0	25g	$168	2021-12-16	Buy

Product number	Packaging	Price	Buy
H63722	5g	$424.65	Buy
H63722	1g	$99.9	Buy
H63722	250mg	$33.2	Buy
C379574	25mg	$120	Buy
089223	25g	$168	Buy

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Chemical Properties,Uses,Production

Uses

(R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine intermediate in the production of (R)-Cetirizine.

Uses

Intermediate in the production of (R)-Cetirizine (C281106).

Application

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine could be used to synthesize a series of novel derivatives. Most of these derivatives significantly affected both allergic asthma and allergic itching. Meanwhile, in the test of allergic itching, five of the 19 compounds have more potent activities than levocetirizine[1].

References

[1] Lisheng Wang. “Design, synthesis, and anti-allergic activities of novel (R)(-)-1-[(4-chlorophenyl)phenyl methyl]piperazine derivatives.” Medicinal Chemistry Research 21 1 (2010): 124–132.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine synthesis

Synthesis of (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine from chlorophenyl)phenylMethyl]-1-piperazi-necarboxylic acid, phenyl ester

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Preparation Products And Raw materials

Raw materials

943987-59-5 chlorophenyl)phenylMethyl]-1-piperazi-necarboxylic acid, phenyl ester Cetirizine Impurity 28

Preparation Products

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine Suppliers

Global( 175)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	+86-23-86815286 +86-13983794297	sales@ensky-chemical.com	China	87	58
Enki Biopharmaceuticals (Shanghai) Limited	+86-0086-2157680326 +8613916707528	yusu@enkibiopharma.com	China	47	58
Capot Chemical Co.,Ltd.	571-85586718 +8613336195806	sales@capotchem.com	China	29797	60
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Alchem Pharmtech,Inc.	8485655694	sales@alchempharmtech.com	United States	63711	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	47465	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12377	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58

Supplier	Advantage
Chongqing Ensky Pharmaceutical Co.,Ltd.	58
Enki Biopharmaceuticals (Shanghai) Limited	58
Capot Chemical Co.,Ltd.	60
Henan Tianfu Chemical Co.,Ltd.	55
Hubei Jusheng Technology Co.,Ltd.	58
Hubei xin bonus chemical co. LTD	58
Alchem Pharmtech,Inc.	58
CONIER CHEM AND PHARMA LIMITED	58
Zhengzhou Alfa Chemical Co.,Ltd	58
SIMAGCHEM CORP	58

View Lastest Price from (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-09-20	(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0	US $0.00-0.00 / kg	1kg	98%	1Ton	Henan Aochuang Chemical Co.,Ltd.
	2021-01-06	(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0	US $1.00 / g	1g	85.0-99.8%	20tons	Career Henan Chemica Co

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
US $0.00-0.00 / kg
98%
Henan Aochuang Chemical Co.,Ltd.

(R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine
300543-56-0
US $1.00 / g
85.0-99.8%
Career Henan Chemica Co

300543-56-0((R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine)Related Search:

(S)-(+)-Epichlorohydrin Acetic acid, 2-[2-[2-[4-[(4- chlorophenyl)phenylMethyl]-1-piperazinyl]ethoxy]ethoxy]- Levocetirizine Impurity 4 Levocetirizine amide impurity HCl 1-(o-Chloro-α-phenylbenzyl)piperazine

Piperazine D-3-Bromocamphor-8-sulfonic acid ammonium salt

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(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE (R)-(-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (R)-1-(p-Chlorobenzhydryl)piperazine Piperazine,1-[(R)-(4-chlorophenyl)phenylMethyl]- (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine, 97% (R)-1-[alpha-(4-Chlorophenyl)benzyl]piperazine Levocetirizine Impurity 2 Levocetirizine Impurity A (130018-88-1) (-)-1-((4-chlorophenyl)phenylmethyl)piperazine (R)-Cetirizine EP Impurity A (R)-1-[(4-Chlorophenyl)phenylmethyl (R)-Cetirizine EP Impurity A (Levocetirizine Impurity 2) Levocetirizine Chlorobenzhydryl Piperazine (USP) (R)-1-[^a-(4-Chlorophenyl)benzyl]piperazine,97% (R)-(-)-1-[(4-chlorophenyl)phenmethyl]piperazine (R)-1-((4-Chlorophenyl)(phenyl)methyl)piperazine (Cetirizine Impurity) Chlorobenzhydryl Piperazine (F02160) TIANFUCHEM--(-)-1-[(4-CHLOROPHENYL)PHENYLMETHYL]PIPERAZINE R(-)-1-[(4-Chlorophenyl)benzyl]piperazine Levocetirizine Impurity 1 (Chlorobenzhydryl piperazine) (-)-1-[( 4-ChIorophenyI)PhenyImethyI] Piperazine (R)-Cetirizine EP Impurity A ((R)-Hydroxyzine USP Related Compound A) (R)-N-(4-Chlorobenzyl hydryl) piperazine (R)-1-[(4-chlorophenyl)phenyl methyl] Piperazine (Intermediate of Levocetirizine ) (R)-1-[(4-Chlorophenyl)phenylmethyl]piperazine (-)-1-[(4-Chlorophenyl)phenylmethyl]piperazine 300543-56-0 Aromatics Chiral Reagents Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Pharmaceutical Intermediates