ChemicalBook >> CAS DataBase List >>2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- structure

CAS No.: 1675201-83-8

Chemical Name:: 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-

Synonyms: BMS-1;T3655;CS-2413;avelumab/PD-L1;PD-1PD-L1 inhibitor;PD1-PDL1 inhibitor 1;PD-1/PD-L1 inhibitor 1(C1);BMS-1 (PD-1/PD-L1 inhibitor 1);PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1);PD-1/PD-L1 inhibitor Impurity 8 (BMS 1)

CBNumber:: CB23049190

Molecular Formula:: C29H33NO5

Molecular Weight:: 475.58

MDL Number:: MFCD28978741

MOL File:: 1675201-83-8.mol

Last updated:2023-06-08 09:02:45

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Properties

Boiling point	630.2±55.0 °C(Predicted)
Density	1.182±0.06 g/cm3(Predicted)
storage temp.	-20°C
solubility	Soluble in DMSO (up to at least 25 mg/ml) or in Ethanol (up to 20 mg/ml)
pka	2.34±0.20(Predicted)
form	solid
color	White
Stability	Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20°C for up to 3 months.

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P305+P351+P338

NFPA 704

	0
2		0

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- price More Price(23)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	19914	PD-1/PD-L1 Inhibitor 1 ≥98%	1675201-83-8	1mg	$36	2024-03-01	Buy
Cayman Chemical	19914	PD-1/PD-L1 Inhibitor 1 ≥98%	1675201-83-8	5mg	$112	2024-03-01	Buy
Cayman Chemical	19914	PD-1/PD-L1 Inhibitor 1 ≥98%	1675201-83-8	10mg	$207	2024-03-01	Buy
Cayman Chemical	19914	PD-1/PD-L1 Inhibitor 1 ≥98%	1675201-83-8	25mg	$384	2024-03-01	Buy
ChemScene	CS-5545	BMS-1 99.61%	1675201-83-8	100mg	$1056	2021-12-16	Buy

Product number	Packaging	Price	Buy
19914	1mg	$36	Buy
19914	5mg	$112	Buy
19914	10mg	$207	Buy
19914	25mg	$384	Buy
CS-5545	100mg	$1056	Buy

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Chemical Properties,Uses,Production

Description

PD-1/PD-L1 Inhibitor 1 (1675201-83-8) inhibits (IC50 = <100nM) the formation of the PD-1/PD-L1 complex via binding to PD-L1 and inducing dimerization.1

Uses

BMS-1 is a PD-L1 inhibitor which is used in combination with LIF inhibitors for the treatment of cancers.

in vitro

pd-1/pd-l1 inhibitor 1 has been identified to be a potent and selective small molecule inhibitor blocking the interaction of programmed cell death protein 1 (pd-1) with its ligand protein (pd-l1). pd-1/pd-l1 inhibitor 1 was also found to act as an immunomodulator. in preclinical studies, pd-1/pd-l1 inhibitor 1 was able to block pd-1/pd-ll interactions with an ic50 value between 6 and 100 nm, which was measured by a homogenous time-resolved fluorescence (htrf) binding assay. thus, pd-1/pd-l1 inhibitor 1 might potentially be used for the treatment of cancer as well as infectious diseases, such as hepatitis c [1].

IC 50

0.006-0.10 μm

References

1) Chupak?et al. (2015), Compounds Useful as Immunomodulators; WO2015/034820

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Preparation Products And Raw materials

Raw materials

Preparation Products

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Suppliers

Global( 103)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
ATK CHEMICAL COMPANY LIMITED	+undefined-21-51877795	ivan@atkchemical.com	China	32480	60
Biochempartner	0086-13720134139	candy@biochempartner.com	CHINA	967	58
career henan chemical co	+86-0371-86658258 15093356674;	factory@coreychem.com	China	29826	58
Fuxin Pharmaceutical	+86-021-021-50872116 +8613122107989	contact@fuxinpharm.com	China	10297	58
Hubei Ipure Biology Co., Ltd	+8613367258412	ada@ipurechemical.com	China	10326	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	86 18062405514 18062405514	ada@ipurechemical.com	CHINA	3465	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	86-571-88216897,88216896 13588875226	sales@hzclap.com	CHINA	6313	58
Chemia Biotechnology（Shanghai） Co., Ltd	+8613816753574	info@chemia-pharm.com	CHINA	311	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
InvivoChem	+1-708-310-1919 +1-13798911105	sales@invivochem.cn	United States	6393	58

Supplier	Advantage
ATK CHEMICAL COMPANY LIMITED	60
Biochempartner	58
career henan chemical co	58
Fuxin Pharmaceutical	58
Hubei Ipure Biology Co., Ltd	58
HONG KONG IPURE BIOLOGY CO.,LIMITED	58
HANGZHOU CLAP TECHNOLOGY CO.,LTD	58
Chemia Biotechnology（Shanghai） Co., Ltd	58
Zhejiang J&C Biological Technology Co.,Limited	58
InvivoChem	58

View Lastest Price from 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2019-12-20	2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- 1675201-83-8	US $1.00 / g	1g	99%	KG/T	Career Henan Chemical Co

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-
1675201-83-8
US $1.00 / g
99%
Career Henan Chemical Co

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- Spectrum

2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)-(1675201-83-8)¹HNMR

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2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- PD1-PDL1 inhibitor 1 PD-1PD-L1 inhibitor (2S)-1-[[2,6-Dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-2-piperidinecarboxylic acid avelumab/PD-L1 T3655 (2S)-1-{2,6-Dimethoxy-4-[(2-methyl-3-biphenylyl)methoxy]benzyl}-2-piperidinecarboxylic acid PD1-PDL1 inhibitor 1 (PD1-PDL1-IN1) BMS-1 (PD-1/PD-L1 inhibitor 1) CS-2413 PD1/PDL1 INHIBITOR 1;PD 1/PD L1 INHIBITOR 1 PD-1/PD-L1 inhibitor 1(C1) BMS-1 PD-1/PD-L1 inhibitor Impurity 8 (BMS 1) 2-Piperidinecarboxylic acid, 1-[[2,6-dimethoxy-4-[(2-methyl[1,1'-biphenyl]-3-yl)methoxy]phenyl]methyl]-, (2S)- (S)-1-(2,6-Dimethoxy-4-((2-methyl-[1,1'-biphenyl]-3-yl)methoxy)benzyl)piperidine-2-carboxylic acid 1675201-83-8