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Verbascoside

Description Natural occurrences Mechanism of action
Verbascoside
Verbascoside structure
CAS No.
61276-17-3
Chemical Name:
Verbascoside
Synonyms
Kusagi;TJC 160;Acetoside;KUSAGININ;ACTEOSIDE;NSC 603831;Russetinol;Verbacoside;VERBASCOSIDE;StereosperMin
CBNumber:
CB2306760
Molecular Formula:
C29H36O15
Formula Weight:
624.59
MOL File:
61276-17-3.mol

Verbascoside Properties

Melting point:
232℃
Boiling point:
908.8±65.0 °C(Predicted)
Density 
1.60±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Room Temperature
pka
9.31±0.10(Predicted)
InChIKey
FBSKJMQYURKNSU-ZLSOWSIRSA-N
CAS DataBase Reference
61276-17-3(CAS DataBase Reference)
FDA UNII
3TGX09BD5B
SAFETY
  • Risk and Safety Statements
Safety Statements  24/25
WGK Germany  2
RTECS  LZ5786000
HS Code  29389090
Toxicity LD50 oral in rat: > 5gm/kg

Verbascoside price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 1711455 Verbascoside United States Pharmacopeia (USP) Reference Standard 61276-17-3 15mg $429 2021-03-22 Buy
Sigma-Aldrich 00820580 Verbascoside primary pharmaceutical reference standard 61276-17-3 10mg $441 2021-03-22 Buy
TCI Chemical V0153 Verbascoside >97.0%(HPLC) 61276-17-3 10mg $217 2021-03-22 Buy
TCI Chemical V0153 Verbascoside >97.0%(HPLC) 61276-17-3 50mg $652 2021-03-22 Buy
Cayman Chemical 24965 Verbascoside ≥98% 61276-17-3 1mg $35 2021-03-22 Buy

Verbascoside Chemical Properties,Uses,Production

Description

Verbascoside is isolated from Lantana camara, acts as an ATP-competitive inhibitor of PKC, with an IC50 of 25 µM, and has antitumor, anti-inflammatory and antineuropathic pain activity.

Natural occurrences

Verbascoside can be found in species in all the families of the order Lamiales (syn. Scrophulariales). Only two examples are known from outside the order,in the clade Asterids.

Mechanism of action

It is known, that amyloid fibrils accumulation in cerebral can easily lead to neurodegenerative disorders. Acteoside has been reported to inhibit Aβ42 aggregation by activating nuclear translocation of the transcription factor NF-E2-related factor 2 (Nrf2), increasing heme oxygenase-1 (HO-1) expression. It has also been shown that acteoside could decrease nitric oxide synthase (NOS) activity and caspase-3 expression.

Chemical Properties

White solid

Enzyme inhibitor

This plant glycoside and antioxidant (FW = 624.60 g/mol; CAS 61276-173), also known as verbascoside, inhibits TNFa-mediated apoptosis in LPSstimulated macrophages as well as 1-methyl-4-phenylpyridiniuminduced apoptosis in cerebellar granule neurons. It also inhibits proliferation of human promyelocytic HL-60 leukemia cells by inducing cell cycle arrest at the G0/G1 phase, followed by differentiation into monocytes. Acteoside inhibits PMA-induced invasion and migration of human fibrosarcoma cells by Ca2+-dependent CaMK/ERK and JNK/NFκB-signaling pathways. Acteoside thus shows the potential as antimetastatic agent. Another intriguing finding is that acteoside inhibits amyloid-β aggregation. Target(s): aldose reductase; protein kinase C; integrase, HIV-1; peptidyl-dipeptidase A, or angiotensin-converting enzyme; tyrosinase, or monophenol monooxygenase; 5-lipoxygenase, or arachidonate 5-lipoxygenase.

Verbascoside Preparation Products And Raw materials

Raw materials

Preparation Products


Verbascoside Suppliers

Global( 227)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Shanghai Standard Technology Co., Ltd.
18502101150
+86-21-57127007-6606 ft-sales@nature-standard.com CHINA 1923 58
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 21032 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com CHINA 8882 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Nanjing Dolon Biotechnology Co.,Ltd.
18905173768
sales@dolonchem.com CHINA 2972 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Xi'an Kono chem co., Ltd.,
13289246953 029-86107037
info@konochemical.com CHINA 3000 58

View Lastest Price from Verbascoside manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-09-26 Acteoside Kusaginin 61276-17-3
61276-17-3
US $29.00 / mg 20mg ≥98% 1000.00 kgs NanJing Spring & Autumn Biological Engineering CO., LTD.
2021-08-12 Desertliving Cistanche Extract
61276-17-3
US $0.00 / Kg/Bag 2Kg/Bag Echinacoside 80% 20 tons Sinoway Industrial co., ltd.
2020-05-11 Acteoside
61276-17-3
US $0.00 / mg 5mg Analytical Standard 10 g Shanghai Standard Technology Co., Ltd.

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