N-TETRADECYLPHOSPHONIC ACID
- CAS No.
- 4671-75-4
- Chemical Name:
- N-TETRADECYLPHOSPHONIC ACID
- Synonyms
- TDPA;TETRADECYL PHOSPHONATE;myristylphosphonic acid;tetradecyl-phosphonicaci;tetradecanephosphonicacid;TETRADECYLPHOSPHONIC ACID;N-TETRADECYLPHOSPHONIC ACID;1-tetradecylphosphonic acid;1-TETRADECANEPHOSPHONIC ACID;P-tetradecyl-Phosphonic acid
- CBNumber:
- CB2309695
- Molecular Formula:
- C14H31O3P
- Molecular Weight:
- 278.37
- MDL Number:
- MFCD00015834
- MOL File:
- 4671-75-4.mol
| Melting point | 96-98°C |
|---|---|
| Boiling point | 175.8°C |
| Density | 0.998±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | ≥27.8 mg/mL in ETOH; insoluble in H2O; ≥2.27 mg/mL in DMSO with gentle warming and ultrasonic |
| form | Powder |
| pka | 2.65±0.10(Predicted) |
| color | white to off-white |
| Water Solubility | Soluble in ethanol, dimethyl sulfoxide and dimethyl formamide. Partially soluble in water. |
| InChIKey | BVQJQTMSTANITJ-UHFFFAOYSA-N |
| CAS DataBase Reference | 4671-75-4 |
| EPA Substance Registry System | Phosphonic acid, tetradecyl- (4671-75-4) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H303-H315-H319-H335 | |||||||||
| Precautionary statements | P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 26-36/37/39 | |||||||||
| WGK Germany | 2 | |||||||||
| RTECS | TA0460000 | |||||||||
| TSCA | Yes | |||||||||
| HS Code | 29319090 | |||||||||
| NFPA 704 |
|
N-TETRADECYLPHOSPHONIC ACID price More Price(19)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 736414 | Tetradecylphosphonic acid 97% | 4671-75-4 | 1g | $113 | 2024-03-01 | Buy |
| Sigma-Aldrich | 736414 | Tetradecylphosphonic acid 97% | 4671-75-4 | 5g | $331 | 2024-03-01 | Buy |
| Sigma-Aldrich | 736414 | Tetradecylphosphonic acid 98% | 4671-75-4 | 100G | $1420 | 2023-06-20 | Buy |
| TCI Chemical | T3183 | Tetradecylphosphonic Acid >98.0%(T) | 4671-75-4 | 1g | $87 | 2024-03-01 | Buy |
| TCI Chemical | T3183 | Tetradecylphosphonic Acid >98.0%(T) | 4671-75-4 | 5g | $308 | 2024-03-01 | Buy |
N-TETRADECYLPHOSPHONIC ACID Chemical Properties,Uses,Production
Physical state
N-TETRADECYLPHOSPHONIC ACID is a white to off-white powder.
Shipping Condition
Room Temperature; may vary elsewhere.
Uses
1-Tetradecylphosphonic acid is used to functionalize the surface of BaTiO3 nanoparticles.
Uses
TDPA can be used to cap copper nanoparticles to protect them from oxidation. It may also be used in the synthesis of cadmium sulfate (CdS) core, which can be used in the fabrication of cadmium selenium (CdSe)/CdS core quantum dots (QDs). It may also be coated on caesium lead bromide (CsPbBr3) perovskite quantum dots for the development of white light emitting diodes (wLED).
General Description
Tetradecylphosphonic acid forms a self-assembled monolayer (SAM) to functionalize a variety of nanoparticles.
Biological Activity
tetradecyl phosphonate is a pan-antagonist of lysophosphatidic acid 1 (lpa1), lpa2, and lpa3 receptors. the ic50 value for inhibition of lpa-induced calcium mobilization was 10 μm, 5.5 μm, and 3.1 μm, respectively. at a concentration of 10 μm, tetradecyl phosphonate activates a peroxisome proliferator-activated receptor γ reporter construct 4-fold when compared with the controls and partially inhibits autotaxin with an ic50 value of approximately 3 μm [1].lysophosphatidic acid (lpa), also known as autotaxin (atx), is a lipid signalling molecule formed by the hydrolysis of lysophosphatidyl choline by lysophospholipase d [2]. lpa signals through four different g protein-coupled receptors, named as lpa1/edg-2, lpa2/edg-4, lpa3/edg-7, and lpa4/gpr23 [3]. it has been reported that lpa was involved in activating peroxisome proliferator-activated receptor γ (pparγ) [4].
References
[1]. durgam g g, virag t, walker m d, et al. synthesis, structure activity relationships, and biological evaluation of fatty alcohol phosphates as lysophosphatidic acid receptor ligands, activators of pparγ, and inhibitors of autotaxin[j]. journal of medicinal chemistry, 2005, 48(15): 4919-4930.
[2]. tokumura a, majima e, kariya y, et al. identification of human plasma lysophospholipase d, a lysophosphatidic acid-producing enzyme, as autotaxin, a multifunctional phosphodiesterase[j]. journal of biological chemistry, 2002, 277(42): 39436-39442.
[3]. noguchi k, ishii s, shimizu t. identification of p2y9/gpr23 as a novel g protein-coupled receptor for lysophosphatidic acid, structurally distant from the edg family[j]. journal of biological chemistry, 2003, 278(28): 25600-25606.
[4]. mcintyre t m, pontsler a v, silva a r, et al. identification of an intracellular receptor for lysophosphatidic acid (lpa): lpa is a transcellular pparγ agonist[j]. proceedings of the national academy of sciences, 2003, 100(1): 131-136.
N-TETRADECYLPHOSPHONIC ACID Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hangzhou FandaChem Co.,Ltd. | 008657128800458; +8615858145714 | fandachem@gmail.com | China | 9348 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Zhengzhou Yuanli Biological Technology Co., Ltd | 0086-371-67897895 | info@zzyuanli.cn | CHINA | 136 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Hefei TNJ Chemical Industry Co.,Ltd. | 0551-65418671 | sales@tnjchem.com | China | 34572 | 58 |
| CD Chemical Group Limited | +8615986615575 | info@codchem.com | China | 20356 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| SUZHOU SENFEIDA CHEMICAL CO.,LTD | +86-0512-83500002 +8615195660023 | sales@senfeida.com | China | 5100 | 58 |
| Henan Allgreen Chemical Co.,LTD | +86-37155567971 +86-13633837469 | info@allgreenchem.com | China | 5986 | 58 |
