ethyl-2,2-dimethyl-7-bromoheptanoate
- CAS No.
- 123469-92-1
- Chemical Name:
- ethyl-2,2-dimethyl-7-bromoheptanoate
- Synonyms
- ethyl 7-bromo-2,2-dimethylheptanoate;ETC-1002 intermediate 2;Intermediate of bepridil;Bempedoic Acid Impurity 9;Bepidoic acid impurity 11;Bempedoic acid intermediate;Bempedoic Acid Intermediates;7-bromo-2,2-dimethylheptanoate;ethyl-2,2-dimethyl-7-bromoheptanoate;7-Bromo-2,2-dimethylheptanoic acid ethyl ester
- CBNumber:
- CB23105876
- Molecular Formula:
- C11H21BrO2
- Molecular Weight:
- 265.19
- MDL Number:
- MFCD27942427
- MOL File:
- 123469-92-1.mol
| Product description | Number | Pack Size | Price |
| 7-Bromo-2,2-dimethylheptanoicacidethylester | CS-M3640 | 1g | $68 |
| 7-Bromo-2,2-dimethylheptanoicacidethylester | CS-M3640 | 5g | $205 |
| ethyl7-bromo-2,2-dimethylheptanoate 95%+ | CM329574 | 500g | $1840 |
| Ethyl7-bromo-2,2-dimethylheptanoate 97% | A606282 | 1g | $6 |
| Ethyl7-bromo-2,2-dimethylheptanoate 97% | A606282 | 5g | $22 |
| Boiling point | 106-108 °C(Press: 0.01 Torr) |
|---|---|
| Density | 1.169±0.06 g/cm3(Predicted) |
| vapor pressure | 0.0±0.6 mmHg at 25°C |
| refractive index | 1.463 |
| Flash point | 146.4±13.0 °C |
| storage temp. | Store at room temperature |
| Appearance | Colorless to light yellow Liquid |
| InChI | InChI=1S/C11H21BrO2/c1-4-14-10(13)11(2,3)8-6-5-7-9-12/h4-9H2,1-3H3 |
| InChIKey | SYRIIFZUZOIRNU-UHFFFAOYSA-N |
| SMILES | C(OCC)(=O)C(C)(C)CCCCCBr |
| LogP | 3.92 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| RIDADR | UN2810 |
| HazardClass | 6.1 |
| HS Code | 2915907098 |
| Limited Quantities | 5.0 L (1.3 gallons) (liquid) or 5.0 kg (11 lbs) (solid) |
| Excepted Quantities | Max Inner Pack (30g or 30ml) and Max Outer Pack (1Kg or 1L) |
ethyl-2,2-dimethyl-7-bromoheptanoate price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-M3640 | 7-Bromo-2,2-dimethylheptanoicacidethylester | 123469-92-1 | 1g | $68 | 2021-12-16 | Buy |
| ChemScene | CS-M3640 | 7-Bromo-2,2-dimethylheptanoicacidethylester | 123469-92-1 | 5g | $205 | 2021-12-16 | Buy |
| Chemenu | CM329574 | ethyl7-bromo-2,2-dimethylheptanoate 95%+ | 123469-92-1 | 500g | $1840 | 2021-12-16 | Buy |
| Ambeed | A606282 | Ethyl7-bromo-2,2-dimethylheptanoate 97% | 123469-92-1 | 1g | $6 | 2021-12-16 | Buy |
| Ambeed | A606282 | Ethyl7-bromo-2,2-dimethylheptanoate 97% | 123469-92-1 | 5g | $22 | 2021-12-16 | Buy |
ethyl-2,2-dimethyl-7-bromoheptanoate Chemical Properties,Uses,Production
Description
Ethyl 7-bromo-2,2-dimethylheptanoate is an important raw material in the synthesis route of bepetidic acid. Bempedoic acid, whose chemical name is 8-hydroxy-2,2,14,14-tetramethylpentadecanedioic acid, also known as ETC-1002, is a new type of lipid developed by the American EsperionTherapeutic company Quality regulation small molecule drugs. As one of the company's main drug candidates, its targets are liver adenosine triphosphate-citrate lyase (ACL) and adenosine monophosphate-activated protein kinase (AMPK).
Uses
Ethyl-2,2-dimethyl-7-bromoheptanoate can be used as an intermediate in organic synthesis, mainly used in laboratory research and development and chemical production processes.
Synthesis
The specific embodiment of the present invention is as follows: prepare 19.4g (167mmol) of ethyl isobutyrate in 216mL solution of tetrahydrofuran with a mass concentration of 10%, connect to metering pump 1; prepare 84mL (168mmol) of 2.0M n-butyllithium solution, connect to meter Pump 2; configure 1,5-dibromopentane 80.0g (348mmol) tetrahydrofuran 100mL solution, mass concentration is 63%, connected to metering pump 3.Configure 300mL of 1N hydrochloric acid solution and connect to metering pump 4.Set continuous flow precooler 1, the circulating temperature is 0, and reach stability; set continuous flow precooler 2, the circulating temperature is 0, and reach stability; set continuous flow precooler 3, and the circulating temperature is 0, and reach stability; set continuous flow precooler 4, cycle temperature is 0, and reach stability;Set the flow rate of metering pump 1 to 65.0ml/min, set the flow rate of metering pump 2 to 25.0ml/min, set the flow rate of metering pump 3 to 30.0ml/min, and set the flow rate of metering pump 4 to 90.0ml/min.Turn on the metering pump 1 and metering pump 2 at the same time. After 60s of operation, turn on the metering pump 3, and after 60s of operation, turn on the metering pump 4 to collect the outflowing reaction liquid in the storage tank.After the operation is completed, separate the liquids, collect the upper organic phase, concentrate under reduced pressure at P=-0.08MPa, T=45??C to remove low-boiling solvents, and then rectify under reduced pressure at P=5mmHg and T=70??C to obtain 38.4 g.The obtained product is a colorless liquid with a GC purity of 98.6% and a yield of 87%.
ethyl-2,2-dimethyl-7-bromoheptanoate Preparation Products And Raw materials
Raw materials
Preparation Products
ethyl-2,2-dimethyl-7-bromoheptanoate Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Jinan Carbotang Biotech Co.,Ltd. | +8615866703830 | figo.gao@foxmail.com | China | 8497 | 58 |
| weifang runzhong fine chemical co., ltd | 536-7868377 +8618653686003 | sq@runzhongchem.com | China | 187 | 58 |
| AstaTech(Chengdu) Biopharmaceutical Corp. | +86-02882666559 +86-15884417729 | gjpu@astatech.com.cn | China | 308 | 58 |
| Shanghai Famo Biotech Co Ltd | +86-36680037 +86-18550473860 | mayan@famobiotech.com;sales@famobiotech.com | China | 528 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20134 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Speranza Chemical Co., Ltd. | +86-86-075521030354 +8618688942810 | sophieliu@speranzachem.com | China | 925 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | factory@coreychem.com | China | 29798 | 58 |
| Zhengzhou Alfa Chemical Co.,Ltd | +8618530059196 | sale04@alfachem.cn | China | 11767 | 58 |
| China fortune way company | +8610 84669320 17865159269 | rnd@sinopharmintl.com | CHINA | 117 | 58 |
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- Ethyl-2,2-dimethyl-7-bromoheptanoate is crucial for bempedoic acid synthesis, ensuring high efficiency and purity, advancing p....
- Apr 8，2024
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- Dec 8，2022
View Lastest Price from ethyl-2,2-dimethyl-7-bromoheptanoate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-09-25 | ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
|
US $8.00-2.00 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-05-20 | Ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
|
US $0.00-0.00 / KG | 1KG | 97.0-99.0%min GC | 5-10tons/year | AstaTech(Chengdu) Biopharmaceutical Corp. | |
 |
2019-12-25 | ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
|
US $0.01 / KG | 1KG | 95%-99% | 1kg; 100kg； 500kg | Career Henan Chemical Co |
-
- ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
- US $8.00-2.00 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- Ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
- US $0.00-0.00 / KG
- 97.0-99.0%min GC
- AstaTech(Chengdu) Biopharmaceutical Corp.
-
- ethyl-2,2-dimethyl-7-bromoheptanoate
123469-92-1
- US $0.01 / KG
- 95%-99%
- Career Henan Chemical Co
