BMS-582949 (hydrochloride)
- CAS No.
- 912806-16-7
- Chemical Name:
- BMS-582949 (hydrochloride)
- Synonyms
- BMS-582949 (hydrochloride);BMS-582949 hydrochloride, 10 mM in DMSO;BMS 582949,BMS 582949 hydrochloride,Inhibitor,BMS582949,Autophagy,BMS-582949,inhibit,BMS582949 hydrochloride,p38 MAPK
- CBNumber:
- CB23126697
- Molecular Formula:
- C22H27ClN6O2
- Molecular Weight:
- 442.94178
- MDL Number:
- MFCD30187517
- MOL File:
- 912806-16-7.mol
- MSDS File:
- SDS
storage temp. | Store at -20°C |
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solubility | ≥44.3 mg/mL in DMSO with gentle warming; insoluble in H2O; ≥2.7 mg/mL in EtOH with gentle warming and ultrasonic |
form | solid |
color | White to off-white |
FDA UNII | 3Z6GAP3R9Q |
SAFETY
Risk and Safety Statements
Symbol(GHS) | ![]() GHS07 |
---|---|
Signal word | Warning |
Hazard statements | H302-H315-H319-H335 |
Precautionary statements | P261-P305+P351+P338 |
HS Code | 2933998090 |
BMS-582949 (hydrochloride) price
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
ChemScene | CS-5621 | BMS-582949hydrochloride 98.82% | 912806-16-7 | 5mg | $150 | 2021-12-16 | Buy |
ApexBio Technology | B7850 | BMS-582949hydrochloride | 912806-16-7 | 5mg | $150 | 2021-12-16 | Buy |
Apolloscientific | BISN0242 | BMS-582949hydrochloride | 912806-16-7 | 5mg | $203 | 2021-12-16 | Buy |
ChemScene | CS-5621 | BMS-582949hydrochloride 98.82% | 912806-16-7 | 25mg | $500 | 2021-12-16 | Buy |
Apolloscientific | BISN0242 | BMS-582949hydrochloride | 912806-16-7 | 25mg | $682 | 2021-12-16 | Buy |
BMS-582949 (hydrochloride) Chemical Properties,Uses,Production
Biological Activity
bms-582949 hydrochloride is a novel, potent and highly selective p38α mitogen-activated protein kinase (p38α mapk) inhibitor [1].the p38α map kinase plays a critical role in regulating the production of many inflammatory cytokines, including tnf-α and il-1β. excessive production of tnf-α and il-1β has been implicated in many inflammatory diseases [1].bms-582949 hydrochloride potently inhibited the activity of p38α mapk with the ic50 value of 13 nm [1]. bms-582949 showed no significant effects on cytochrome p450 isozymes 1a2, 2c9, 2c19, and 2d6 with the ic50 values of >40 μm. bms-582949 weakly inhibited the activity of cyp3a4, with the ic50 value of 18-40 μm. bms-582949 displayed >2000-fold selectivity for p38α over a diverse panel of 57 kinases, include serine kinases, receptor tyrosine kinases, nonreceptor tyrosine kinases, and the p38γ and δ isoforms. bms-582949 showed 450-fold selectivity over jnk2, a map kinase involved in inflammation, and 190-fold selective over raf [1]. in mice, after oral administration of bms-582949 (10 mg/kg), the clearance rate for bms-582949 is 4.4 ml/min/kg. bms-582949 exhibited oral bioavailability values of 90% and 60% in mice and rats, respectively [1].bms-582949 is currently under phase ii
References
[1] liu c, lin j, wrobleski s t, et al. discovery of 4-(5-(cyclopropylcarbamoyl)-2-methylphenylamino)-5-methyl-n-propylpyrrolo [1, 2-f][1, 2, 4] triazine-6-carboxamide (bms-582949), a clinical p38α map kinase inhibitor for the treatment of inflammatory diseases[j]. journal of medicinal chemistry, 2010, 53(18): 6629-6639.
[2] emami h, vucic e, subramanian s, et al. the effect of bms-582949, a p38 mitogen-activated protein kinase (p38 mapk) inhibitor on arterial inflammation: a multicenter fdg-pet trial[j]. atherosclerosis, 2015, 240(2): 490-496.
BMS-582949 (hydrochloride) Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32965 | 60 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 32161 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6391 | 58 |
TargetMol Chemicals Inc. | support@targetmol.com | United States | 38631 | 58 | |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52924 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131957 | 58 |
Haoyuan Chemexpress Co., Ltd. | 021-58950125 | info@chemexpress.com | China | 7552 | 61 |
Shanghai EFE Biological Technology Co., Ltd. | 021-65675885 18964387627 | info@efebio.com | China | 9805 | 58 |
ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |
Shanghai Chaolan Chemical Technology Center | 021-QQ:65489617 15618227136 | Sales@ATKchemical.com | China | 7312 | 58 |
View Lastest Price from BMS-582949 (hydrochloride) manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
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2024-11-19 | BMS-582949 hydrochloride
912806-16-7
|
US $47.00-108.00 / mg | 98.75% | 10g | TargetMol Chemicals Inc. |
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- BMS-582949 hydrochloride
912806-16-7
- US $47.00-108.00 / mg
- 98.75%
- TargetMol Chemicals Inc.