ANTISAUVAGINE-30
- CAS No.
- 220673-95-0
- Chemical Name:
- ANTISAUVAGINE-30
- Synonyms
- ANTISAUVAGINE-30;PubChem ID: 90471086;M.W. 3650.29 C161H274N48O46S;(D-Phe??,His??)-Sauvagine (11-40);(D-PHE11,HIS12)-SAUVAGINE (11-40);11-D-Phenylalanine-12-L-histidine-11-40-sauvagin;(D-PHE11,HIS12)-SAUVAGINE (11-40) TRIFLUOROACETATE SALT;D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THE-ILE-OH;H-D-PHE-HIS-LEU-LEU-ARG-LYS-MET-ILE-GLU-ILE-GLU-LYS-GLN-GLU-LYS-GLU-LYS-GLN-GLN-ALA-ALA-ASN-ASN-ARG-LEU-LEU-LEU-ASP-THR-ILE-NH2
- CBNumber:
- CB2314057
- Molecular Formula:
- C161H273N47O47S
- Molecular Weight:
- 3651.24
- MDL Number:
- MFCD04115623
- MOL File:
- 220673-95-0.mol
- MSDS File:
- SDS
| Product description | Number | Pack Size | Price |
| Antisauvagine-30 | 2071 | 1 | $465 |
| Antisauvagine-30 | B5253 | 1mg | $675 |
| ANTISAUVAGINE-30 95.00% | PEP0004449 | 100MG | $739.2 |
| ANTISAUVAGINE-30 95.00% | PEP0004449 | 1G | $1871.1 |
| Antisauvagine-30 >98% | DC20309 | 1g | $3200 |
SAFETY
Risk and Safety Statements
| Safety Statements | 22-24/25 |
|---|---|
| WGK Germany | 3 |
ANTISAUVAGINE-30 price More Price(7)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Tocris | 2071 | Antisauvagine-30 | 220673-95-0 | 1 | $465 | 2021-12-16 | Buy |
| ApexBio Technology | B5253 | Antisauvagine-30 | 220673-95-0 | 1mg | $675 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004449 | ANTISAUVAGINE-30 95.00% | 220673-95-0 | 100MG | $739.2 | 2021-12-16 | Buy |
| American Custom Chemicals Corporation | PEP0004449 | ANTISAUVAGINE-30 95.00% | 220673-95-0 | 1G | $1871.1 | 2021-12-16 | Buy |
| DC Chemicals | DC20309 | Antisauvagine-30 >98% | 220673-95-0 | 1g | $3200 | 2021-12-16 | Buy |
ANTISAUVAGINE-30 Chemical Properties,Uses,Production
Uses
Antisauvagine-30 (aSvg-30) is a potent, competitive and selective CRF2 receptor antagonist with Kd values of 1.4 nM and 153.6 nM for mouse CRF2β?and rat CRF1?receptors, respectively[1].
Enzyme inhibitor
This highly selective CRF2 antagonist (MW = 3650.29 g/mol; CAS 220673-95-0; Sequence: D-Phe-His-Leu-Leu-Arg-Lys-Met-Ile-Glu-Ile- Glu-Lys-Gln-Glu-Ala-Ala-Asn-Asn-Arg-Leu-Leu-Leu-Asp-Thr-Ile-NH2; Solubility: 5 mg/mL H2O; Alternate Name: [D-Phe 11 ,His 12 ]-Sauvagine (11- 40)) targets human Corticotropin-Releasing hormone (CRH) Receptor-2 subtypes CRF2β (Ki = 1.4 nM), with a much higher value of 154 nM for CRF1. (See also Astressin; K41448) Type-2 GPCRs reside in plasma membranes of hormone-sensitive cells and bind CRH, a peptide hormone and neurotransmitter involved in stress responses. Antisauvagine-30 blocks (pA2 = 8.49) sauvagine-stimulated accumulation of cAMP in HEK-mCRF2β cells. It also prevents stress-enhanced fear conditioning and MEK1/2- dependent activation of ERK1/2 in mice and suggesting a role for protein kinase signaling in the hippocampus and its modulation by CRF2 as a possible link between stress and fear memory.
References
[1] O Brauns, et al. Pharmacological and chemical properties of astressin, antisauvagine-30 and alpha-helCRF: significance for behavioral experiments. Neuropharmacology. 2001 Sep;41(4):507-16. DOI:10.1016/s0028-3908(01)00094-6
[2] Farahnaz Sananbenesi, et al. Mitogen-activated protein kinase signaling in the hippocampus and its modulation by corticotropin-releasing factor receptor 2: a possible link between stress and fear memory. J Neurosci DOI:10.1523/JNEUROSCI.23-36-11436.2003
ANTISAUVAGINE-30 Preparation Products And Raw materials
Raw materials
Preparation Products
ANTISAUVAGINE-30 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shenzhen Nexconn Pharmatechs Ltd | +86-755-89396905 +86-15013857715 | admin@nexconn.com | China | 10405 | 58 |
| Cellmano Biotech Limited | 0551-65326643 18156095617 | info@cellmano.com | China | 995 | 58 |
| Career Henan Chemica Co | +86-0371-86658258 +8613203830695 | laboratory@coreychem.com | China | 30229 | 58 |
| Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 | sales@sarms4muscle.com | China | 10473 | 58 |
| Chengdu Youngshe Chemical Co., Ltd. | +8618108235634 | Cecilia@youngshechem.com | China | 2345 | 58 |
| Nanjing Doge Biomedical Technology Co., Ltd | +86-25-58227606 +86-15305155328 | sales@dogechemical.com | China | 4128 | 58 |
| Nanjing TGpeptide | +86-13347807150 | support@tgpeptide.com | China | 3279 | 58 |
| HANGZHOU LEAP CHEM CO., LTD. | +86-571-87711850 | market18@leapchem.com | China | 43339 | 58 |
| Changsha MOL Changes Biotechnology Co., Ltd. | +8619375158599 | info@molchanges.com | China | 5218 | 58 |
| DAYANG CHEM (HANGZHOU) CO.,LTD | +86-88938639 +86-17705817739 | info@dycnchem.com | China | 53899 | 58 |
