ChemicalBook >> CAS DataBase List >>(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
![(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide Structure](CAS/20180702/GIF/1353644-70-8.gif)
- CAS No.
- 1353644-70-8
- Chemical Name:
- (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
- Synonyms
- HMPL309;HMPL 309;HMPL-309;EOS-61583;Theliatinib;Theliatinib (HMPL-309);ThTheliatinib (HMPL-309);HMPL-309;HMPL 309;HMPL309;(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide;Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]hexahydro-1-methyl-, (3aR,6aR)-
- CBNumber:
- CB23142246
- Molecular Formula:
- C25H26N6O2
- Molecular Weight:
- 442.51
- MDL Number:
- MFCD32173988
- MOL File:
- 1353644-70-8.mol
- MSDS File:
- SDS
Last updated:2023-05-21 10:59:17
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide Properties
| Boiling point | 675.6±55.0 °C(Predicted) |
|---|---|
| Density | 1.35±0.1 g/cm3(Predicted) |
| storage temp. | Store at -20°C |
| solubility | DMSO: 5 mg/mL (11.30 mM) |
| pka | 13.59±0.20(Predicted) |
| FDA UNII | 6ZZ3B7NZ0B |
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide price
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| ChemScene | CS-0027986 | Theliatinib 99.88% | 1353644-70-8 | 5mg | $240 | 2021-12-16 | Buy |
| ChemScene | CS-0027986 | Theliatinib 99.88% | 1353644-70-8 | 10mg | $390 | 2021-12-16 | Buy |
| ChemScene | CS-0027986 | Theliatinib 99.88% | 1353644-70-8 | 25mg | $780 | 2021-12-16 | Buy |
| ChemScene | CS-0027986 | Theliatinib 99.88% | 1353644-70-8 | 50mg | $1300 | 2021-12-16 | Buy |
| ChemScene | CS-0027986 | Theliatinib 99.88% | 1353644-70-8 | 100mg | $2200 | 2021-12-16 | Buy |
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide Chemical Properties,Uses,Production
Biological Activity
Theliatinib (HMPL-309) is a potent EGFR inhibitor with a Ki value of 0.05 nM for EGFR and IC50 values of 3 nM and 22 nM for EGFR and EGFR T790M/L858R mutant, respectively. It is more than 50-fold selective for EGFR over 72 other kinases.
in vitro
Compared with erlotinib or gefitnib, theliatinib has stronger binding affinity to wild-type EGFR and is more difficult to be replaced by ATP, which makes theliatinib have better target binding effect, and the EGFR-activated tumors have stronger antitumor activity.
in vivo
Theliatinib has concentration-dependent antitumor activity in a series of patient-derived esophageal cancer xenograft models. But aberrant activation or genetic mutation of other targets such as PI3K and FGFR attenuates the antitumor activity of EGFR inhibitors, especially theliatinib.
target
| Target | Value |
| WT EGFR (Cell-free assay) | < td style="border-bottom: 1px dotted #ccc;padding: 5px;"> 3 nM|
| EGFR T790M/L858R (Cell-free assay) | 22 nM |
Synthesis of (3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide from (3aR,6aR)-1-Methyl-hexahydropyrrolo[3,4-b]pyrrole and phenyl (4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)carbamate
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide Preparation Products And Raw materials
Raw materials
Preparation Products
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide Suppliers
Global( 38)Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| Nantong HI-FUTURE Biology Co., Ltd. | +undefined18051384581 | sales@chemhifuture.com | China | 3136 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
| Wuhan Jingkangen Biomedical Technology Co., Ltd | 13720134139 13720134139 | orders@jknbiochem.com | China | 4955 | 58 |
| Sichuan Wei Keqi Biological Technology Co., Ltd. | 028-81700200 18116577057 | 3003855609@qq.com | China | 7892 | 56 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| BOC Sciences | 16314854226 | info@bocsci.com | United States | 9926 | 65 |
1353644-70-8((3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide)Related Search:
(3aR,6aR)-N-(4-((3-ethynylphenyl)amino)-7-methoxyquinazolin-6-yl)-1-methylhexahydropyrrolo[3,4-b]pyrrole-5(1H)-carboxamide
EOS-61583
Theliatinib (HMPL-309)
ThTheliatinib (HMPL-309)
Theliatinib
HMPL 309
HMPL309
HMPL-309
HMPL-309;HMPL 309;HMPL309
ATP-competitive,inhibit,EGFR,ERK,cancer,esophageal,Epidermal growth factor receptor,HMPL-309,anti-tumor,Inhibitor,ErbB-1,HMPL309,Theliatinib,HER1,HMPL 309,orally,Xiliertinib,AKT,phosphorylation
Pyrrolo[3,4-b]pyrrole-5(1H)-carboxamide, N-[4-[(3-ethynylphenyl)amino]-7-methoxy-6-quinazolinyl]hexahydro-1-methyl-, (3aR,6aR)-
1353644-70-8