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KMN-80

KMN-80 Structure
KMN-80 structure
CAS No.
1628759-75-0
Chemical Name:
KMN-80
Synonyms
KMN-80;KMN80,KMN 80;CBIUADIJQPJQEZ-VIDOSBHOSA-N;7-((R)-2-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoicacid;1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)-
CBNumber:
CB23152663
Molecular Formula:
C21H33NO4
Molecular Weight:
363.49
MDL Number:
MFCD34469274
MOL File:
1628759-75-0.mol
Last updated:2023-07-14 17:33:41
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KMN-80 Properties

Boiling point 572.1±50.0 °C(Predicted)
Density 1.121±0.06 g/cm3(Predicted)
storage temp. Store at -20°C
solubility DMF: 20 mg/ml; DMSO: 15 mg/ml; Ethanol: 25 mg/ml; Ethanol:PBS(pH 7.2) (1:1): 0.5 mg/ml
form A crystalline solid
pka 4.77±0.10(Predicted)

KMN-80 price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Cayman Chemical 15435 KMN-80 ≥98% 1628759-75-0 500μg $107 2024-03-01 Buy
Cayman Chemical 15435 KMN-80 ≥98% 1628759-75-0 100μg $45 2021-12-16 Buy
Cayman Chemical 15435 KMN-80 ≥98% 1628759-75-0 1mg $169 2024-03-01 Buy
ChemScene CS-0068364 KMN-80 1628759-75-0 1mg $280 2021-12-16 Buy
AK Scientific 3896DW 7-[(2R)-2-[(E,3S,4S)-3-Hydroxy-4-methylnon-1-en-6-ynyl]-5-oxopyrrolidin-1-yl]heptanoicacid 1628759-75-0 1mg $282 2021-12-16 Buy
Product number Packaging Price Buy
15435 500μg $107 Buy
15435 100μg $45 Buy
15435 1mg $169 Buy
CS-0068364 1mg $280 Buy
3896DW 1mg $282 Buy

KMN-80 Chemical Properties,Uses,Production

Description

The prostaglandin E receptor 4 (EP4) is one of four G protein-coupled receptors that mediate the actions of prostaglandin E2 (PGE2; ). Binding of PGE2 to the EP4 receptor causes an increase in intracellular cyclic AMP, which plays important roles in bone formation and resorption, cancer, and atherosclerosis.1,2,3,4 KMN-80 is a substituted γ-lactam (pyrrolidinone) derivative of PGE1 that acts as a selective and potent agonist of EP4 with an IC50 value of 3 nM (IC50 = 1.4 μM for EP3 and > 10 μM for all other prostanoid receptors).5 In functional assays it has been shown to stimulate secreted alkaline phosphatase gene reporter activity in EP4-transfected HEK293 cells with an EC50 value of 0.19 nM, demonstrating >5,000 and 50,000-fold selectivity against EP2 and TP, respectively.5 KMN-80 can induce the differentiation of bone marrow stem cells from both young and aged rats into osteoblasts in vitro (EC50s = 20 and 153 nM, respectively) and exhibits favorable tolerability up to at least 10 μM, whereas the EP4 agonist L-902,688 is highly cytotoxic at similar concentrations in these cells.6 KMN-80 has been used to repair calvarial defects in an in vivo rat craniomaxillofacial reconstruction model (rate of reduction in defect size equivalent to BMP-2 treated rats) and to promote bone formation in a rat incisor tooth socket model.6

References

1. Li, M., Thompson, D.D., and Paralkar, V.M. Prostaglandin E2 receptors in bone formation Int. Orthop. 31(6),767-772(2007).
2. Hawcroft, G., Ko, C.W.S., and Hull, M.A. Prostaglandin E2-EP4 receptor signalling promotes tumorigenic behaviour of HT-29 human colorectal cancer cells Oncogene 26(21),3006-3019(2007).
3. Babaev, V.R., Chew, J.D., Ding, L., et al. Macrophage EP4 deficiency increases apoptosis and suppresses early atherosclerosis Cell Metab. 8(6),492-501(2008).
4. Konya, V., Marsche, G., Schuligoi, R., et al. E-type prostanoid receptor 4 (EP4) in disease and therapy Pharmacol. Ther. 138(3),485-502(2013).
5. Barrett, S.D., Ciske, F.L., Endres, G.W., et al. Novel Potent Lactam Acetylene EP4 Agonists Stimulate Alkaline Phosphatase Production and Differentiation in Bone Marrow Cells ,(2014).
6. O'Malley, J., Uzieblo, A., Germain, B.D., et al. Development of a novel prostaglandin EP4 agonist which stimulates local bone formation in vivo ,(2014).

KMN-80 Preparation Products And Raw materials

Raw materials

Preparation Products

KMN-80 Suppliers

Global( 20)Suppliers
Supplier Tel Email Country ProdList Advantage
Shanghai Hongye Biotechnology Co. Ltd 400-9205774 sales@glpbio.cn China 6870 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 0571-85361029 synstar518@163.com China 1991 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 18818260767 sales@chemegen.com China 11289 58
TargetMol Chemicals Inc. 4008200310 marketing@tsbiochem.com China 24018 58
Shanghai Yifei Biotechnology Co. , Ltd. 021-65675885 18964387627 customer_service@efebio.com China 8740 58
Supplier Advantage
Shanghai Hongye Biotechnology Co. Ltd 58
Hangzhou Synstar pharmaceutical Technology CO.,Ltd 58
ChemeGen(Shanghai) Biotechnology Co.,Ltd. 58
TargetMol Chemicals Inc. 58
Shanghai Yifei Biotechnology Co. , Ltd. 58
KMN-80 CBIUADIJQPJQEZ-VIDOSBHOSA-N 1-Pyrrolidineheptanoic acid, 2-[(1E,3S,4S)-3-hydroxy-4-methyl-1-nonen-6-yn-1-yl]-5-oxo-, (2R)- KMN80,KMN 80 7-((R)-2-((3S,4S,E)-3-hydroxy-4-methylnon-1-en-6-yn-1-yl)-5-oxopyrrolidin-1-yl)heptanoicacid 1628759-75-0