METHACHOLINE CHLORIDE
- CAS No.
- 62-51-1
- Chemical Name:
- METHACHOLINE CHLORIDE
- Synonyms
- amechol;mecholyl;Methacloline;MECHOLYL CHLORIDE;Mecholine chloride;methylacetylcholine;Methacoline chloride;METHACHOLINE CHLORIDE;methacholiniumchloride;MethacholineChloride>
- CBNumber:
- CB2316248
- Molecular Formula:
- C8H18ClNO2
- Molecular Weight:
- 195.69
- MDL Number:
- MFCD00011817
- MOL File:
- 62-51-1.mol
- MSDS File:
- SDS
| Melting point | 171-173 °C(lit.) |
|---|---|
| Density | 1.1028 (rough estimate) |
| refractive index | 1.5790 (estimate) |
| storage temp. | -20°C |
| solubility | H2O: 50 mg/mL, clear, colorless |
| form | powder |
| color | White to Almost white |
| PH | 3.0～7.0 (50g/l, 25℃) |
| Water Solubility | almost transparency |
| Merck | 14,5940 |
| BRN | 4162373 |
| Stability | Unstable - moisture sensitive. Incompatible with oxidizing agents. |
| LogP | -3.957 (est) |
| CAS DataBase Reference | 62-51-1 |
| FDA UNII | 0W5ETF9M2K |
| EPA Substance Registry System | 1-Propanaminium, 2-(acetyloxy)-N,N,N-trimethyl-, chloride (62-51-1) |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H315-H319-H335 | |||||||||
| Precautionary statements | P301+P312+P330-P305+P351+P338 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-36/37/38 | |||||||||
| Safety Statements | 26-36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | BR5250000 | |||||||||
| F | 3-10-21 | |||||||||
| HS Code | 29239000 | |||||||||
| NFPA 704 |
|
METHACHOLINE CHLORIDE price More Price(28)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | A2251 | Acetyl-β-methylcholine chloride ≥98% (TLC), powder | 62-51-1 | 25g | $163 | 2024-03-01 | Buy |
| Sigma-Aldrich | A2251 | Acetyl-β-methylcholine chloride ≥98% (TLC), powder | 62-51-1 | 100g | $541 | 2024-03-01 | Buy |
| TCI Chemical | M0073 | Methacholine Chloride >98.0%(T) | 62-51-1 | 25g | $89 | 2024-03-01 | Buy |
| TCI Chemical | M0073 | Methacholine Chloride >98.0%(T) | 62-51-1 | 500g | $851 | 2024-03-01 | Buy |
| Cayman Chemical | 23092 | Acetyl-β-methylcholine (chloride) ≥95% | 62-51-1 | 5g | $37 | 2024-03-01 | Buy |
METHACHOLINE CHLORIDE Chemical Properties,Uses,Production
Chemical Properties
colourless to white crystalline powder with a slight
Uses
Acetyl-β-methylcholine (methacholine), an analog of acetylcholine, is use as a receptor agonist to study processes such as airway hyperresponsiveness associated with asthma.
Uses
antihypertensive, antianginal
Definition
ChEBI: Methacholine chloride is a quaternary ammonium salt. It contains a methacholine.
General Description
Methacholine chloride occurs as colorless or white crystalsor as a white crystalline powder. It is odorless or has aslight odor and is very deliquescent. It is freely soluble inwater, alcohol, or chloroform, and its aqueous solution isneutral to litmus and bitter. It is hydrolyzed rapidly in alkalinesolutions. Solutions are relatively stable to heat and willkeep for at least 2 or 3 weeks when refrigerated to delaygrowth of molds.
Biochem/physiol Actions
Metabolically stable analog of acetylcholine; muscarinic agonist. Its ability to constrict airway smooth muscle is used to assess bronchial reactivity in the laboratory and clinically.
Clinical Use
Methacholine, acetyl β-methylcholine, is marketed as the racemic mixture. It is a selective muscarinic agonist with very little activity at nicotinic receptors. Although methacholine chloride is marketed as the racemic mixture, the S-(+)-enantiomer is 240-fold more potent than the R-(–)-isomer at muscarinic receptors. In addition, AChE hydrolyzes S-(+)–methacholine at approximately 54% the rate of acetylcholine, whereas the R-(–)–enantiomer is a weak inhibitor. Methacholine chloride is used via inhalation for the diagnosis of asthma. The resulting bronchospasm may be relieved with bronchodilators. Methacholine chloride is available as a powder that is reconstituted for inhalation.
Purification Methods
It forms white hygroscopic needles from Et2O and is soluble in H2O, EtOH and CHCl3. It decomposes readily in alkaline solutions and slowly in H2O. It should be handled and stored in a dry atmosphere. The bromide is less hygroscopic, and the picrate has m 129.5-131o (from EtOH). [racemate: Annis & Ely Biochem J 53 34 1953, IR of iodide: Hansen Acta Chem Scand 13 155 1959, Beilstein 4 IV 1670.]
METHACHOLINE CHLORIDE Preparation Products And Raw materials
Raw materials
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Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9641 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Dideu Industries Group Limited | +86-29-89586680 +86-15129568250 | 1026@dideu.com | China | 29271 | 58 |
| Alfa Chemistry | info@alfa-chemistry.com | United States | 2344 | 58 | |
| Aston Chemical | 13000000000 | sales@astonchem.com | United States | 1634 | 58 |
| Dayang Chem (Hangzhou) Co.,Ltd. | 571-88938639 +8617705817739 | info@dycnchem.com | CHINA | 52867 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| GIHI CHEMICALS CO.,LIMITED | +8618058761490 | info@gihichemicals.com | China | 49999 | 58 |
| Shanghai Acmec Biochemical Technology Co., Ltd. | +undefined18621343501 | product@acmec-e.com | China | 33349 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
View Lastest Price from METHACHOLINE CHLORIDE manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2021-07-28 | METHACHOLINE CHLORIDE USP/EP/BP
62-51-1
|
US $1.10 / g | 1g | 99.9% | 100 Tons min | Dideu Industries Group Limited |
-
- METHACHOLINE CHLORIDE USP/EP/BP
62-51-1
- US $1.10 / g
- 99.9%
- Dideu Industries Group Limited
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