ChemicalBook >> CAS DataBase List >>4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
- CAS No.
- 817194-38-0
- Chemical Name:
- 4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
- Synonyms
- GSK180736A;CS-2541;GSK180736;GSK180736A (GSK180736);GSK180736A >=98% (HPLC);GRK2 inhibitor GS180736A;4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide;5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-;inhibit,ROCK,Inhibitor,ROK,Rho-kinase,Rho-associated kinase,Rho-associated protein kinase,GSK180736A,GSK-180736A
- CBNumber:
- CB23163890
- Molecular Formula:
- C19H16FN5O2
- Molecular Weight:
- 365.36
- MDL Number:
- MFCD30533616
- MOL File:
- 817194-38-0.mol
Last updated:2023-06-08 09:02:57
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H302-H315-H319-H335 | |||||||||
Precautionary statements | P261-P305+P351+P338 | |||||||||
NFPA 704 |
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4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide price More Price(11)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Cayman Chemical | 26182 | GSK180736A | 817194-38-0 | 5mg | $93 | 2024-03-01 | Buy |
Cayman Chemical | 26182 | GSK180736A | 817194-38-0 | 50mg | $502 | 2024-03-01 | Buy |
Cayman Chemical | 26182 | GSK180736A | 817194-38-0 | 10mg | $146 | 2024-03-01 | Buy |
Cayman Chemical | 26182 | GSK180736A | 817194-38-0 | 25mg | $343 | 2024-03-01 | Buy |
ChemScene | CS-6388 | GSK180736A 97.03% | 817194-38-0 | 50mg | $400 | 2021-12-16 | Buy |
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide Chemical Properties,Uses,Production
Biological Activity
GSK180736A (GSK180736) is a Rho-related, coiled-coil protein kinase inhibitor that binds to GRK2 (G protein-coupled receptor kinase 2) with logIC50 of -6.6. The selectivity for GRK2 is more than 400-fold higher than that for GRK1 and GRK5.
in vitro
GSK180736A inhibits GRK2 with IC50 of 770 nM, 300-fold more potent than GRK5. It is a weak PKA inhibitor with IC50=30 μM; it is a potent ROCK1 inhibitor (IC50=100 nM).
target
Target | Value | ||||
ROCK (Cell-free assay) | 100 nM | ||||
GRK2 (Cell-free assay) | 6.6(pIC50) |
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Career Henan Chemica Co | +86-0371-86658258 15093356674; | laboratory@coreychem.com | China | 30255 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Shanghai Boyle Chemical Co., Ltd. | sales@boylechem.com | China | 2923 | 55 | |
Chembest Research Laboratories Limited | 021-20908456 | sales@BioChemBest.com | China | 6011 | 61 |
MedChemexpress LLC | 021-58955995 | sales@medchemexpress.cn | United States | 4863 | 58 |
Mashilabs (Shanghai) Co.,Ltd. | 021-00000000 19916721580 | info@mashilabs.com | China | 4115 | 58 |
817194-38-0(4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide)Related Search:
4-(4-fluorophenyl)-N-(1H-indazol-5-yl)-6-methyl-2-oxo-1,2,3,4-tetrahydropyrimidine-5-carboxamide
CS-2541
GRK2 inhibitor GS180736A
GSK180736
GSK180736A (GSK180736)
5-Pyrimidinecarboxamide, 4-(4-fluorophenyl)-1,2,3,4-tetrahydro-N-1H-indazol-5-yl-6-methyl-2-oxo-
GSK180736A >=98% (HPLC)
GSK180736A
inhibit,ROCK,Inhibitor,ROK,Rho-kinase,Rho-associated kinase,Rho-associated protein kinase,GSK180736A,GSK-180736A
817194-38-0
API