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Troxerutin

Troxerutin
Troxerutin structure
CAS No.
7085-55-4
Chemical Name:
Troxerutin
Synonyms
RUVEN;Z-6000;Venoruton;Rufen P-4;VASTRIBIL;POSORUTIN;7085-55-4;TROXERUTIN;Troxerutine;Factor-P-zyma
CBNumber:
CB2317568
Molecular Formula:
C33H42O19
Formula Weight:
742.68
MOL File:
7085-55-4.mol

Troxerutin Properties

Melting point:
181°C
Boiling point:
1058.4±65.0 °C(Predicted)
Density 
1.65±0.1 g/cm3(Predicted)
storage temp. 
Sealed in dry,Store in freezer, under -20°C
solubility 
Freely soluble in water, slightly soluble in ethanol (96 per cent) and practically insoluble in methylene chloride.
form 
neat
pka
5.92±0.40(Predicted)
Merck 
14,9789
BRN 
4778232
InChIKey
KMPBUGGPUQOWMJ-NXPSPVSKSA-N
CAS DataBase Reference
7085-55-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
7Y4N11PXO8
ATC code
C05CA04,C05CA54
SAFETY
  • Risk and Safety Statements
Safety Statements  22-24/25
WGK Germany  3
RTECS  LK8331500

Troxerutin price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich Y0000497 Troxerutin European Pharmacopoeia (EP) Reference Standard 7085-55-4 y0000497 $190 2020-08-18 Buy
Sigma-Aldrich Y0000497 Troxerutin European Pharmacopoeia (EP) Reference Standard 7085-55-4 $190 2021-03-22 Buy
TCI Chemical T3541 Troxerutin >90.0%(HPLC) 7085-55-4 5g $16 2021-03-22 Buy
TCI Chemical T3541 Troxerutin >90.0%(HPLC) 7085-55-4 25g $47 2021-03-22 Buy
Cayman Chemical 27220 Troxerutin 7085-55-4 25g $69 2021-03-22 Buy

Troxerutin Chemical Properties,Uses,Production

Chemical Properties

Yellow Powder

Originator

Venoruton,Novartis Co

Uses

Used in the treatment of venous disorders

Uses

vasoprotectant

Uses

Troxerutin, a derivative of the naturally occurring bioflavonoid rutin, is thought to inhibit red cell and platelet aggregation, improve erythrocyte deformability, and improve plasma viscosity retinal microcirculation. A double-blind randomized clinical trial compared troxerutin with placebo in 27 patients with CRVO. The limitations of the study included a small number of patients and short follow-up time.

Manufacturing Process

In a nitrogen atmosphere 120 g of caustic soda (3 moles) in solution are added to 610 g of rutin (1 mol) suspended in 2 litres of water, the mixture being vigorously agitated by a mechanical stirrer, 241.5 g of ethylene chlorohydrin being then introduced at 55°C for 10 min. When all the chlorohydrin has been thus added the temperature is progressively raised to 75°C and maintained at this level for 2 hours. After cooling, in a nitrogen atmosphere, the pH value adjusted to 5 by the addition of dilute hydrochloric acid. The solution is kept in an ice box for 24 hours and then filtered to remove any impurities. At reduced pressure the solution is evaporated until dry, the residue taken up in 3 litres of boning methanol which dissolves the tri-(β-hydroxyethyl)rutin formed and leaves the sparingly soluble sodium chloride behind. The tri-(β-hydroxyethyl)rutin is recovered from its methanolic solution either by evaporation and refrigeration, or by evaporation precipitation with absolute ethanol. In either case tri-(β-hydroxyethyl)rutin obtained is in the form of small very hygroscopic crystals which contain alcohol of crystallization.These crystals are quickly shaken washed in a little cold absolute ethanol and then dried in vacuum at 100°C. 680 g of anhydrous tri-(β-hydroxyethyl)rutin are thus obtained in the form of a yellow powder which melts at 156°C.GB Patent No. 833,174; April 21, 1960; Assigned to Zyma S.A., a Swiss Corporation, of Route Etraz, Nyon Canton of Vaud, Switzerland

Therapeutic Function

Topical venotonic

Troxerutin Preparation Products And Raw materials

Raw materials

Preparation Products


Troxerutin Suppliers

Global( 338)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-66670886
info@dakenchem.com China 20914 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
Shanghai Yingrui Biopharma Co., Ltd.
+86-21-33585366 E-mail:sales03@shyrchem.com
+86-21-34979012 sales03@shyrchem.com CHINA 739 60
Nanjing Finetech Chemical Co., Ltd.
025-85710122 17714198479
025-85710122 sales@fine-chemtech.com CHINA 890 55
Hefei TNJ Chemical Industry Co.,Ltd.
+86-0551-65418679
86-0551-65418697 info@tnjchem.com China 3000 55
Shanghai Zheyan Biotech Co., Ltd.
18017610038
zheyansh@163.com CHINA 3623 58
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29954 58
Chengdu GLP biotechnology Co Ltd
13350802083 028-87075086
scglp@glp-china.com CHINA 1824 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com CHINA 2712 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58

View Lastest Price from Troxerutin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-12-01 Troxerutin
7085-55-4
US $0.00 / KG 100g 98%+ 100kg WUHAN CIRCLE POWDER TECHNOLOGY CO.,LTD
2021-11-02 Troxerutin
7085-55-4
US $79.00 / ASSAYS 1ASSAYS 99% 10TONS Baoji Guokang Healthchem co.,ltd
2021-10-20 Troxerutin
7085-55-4
US $75.00-62.00 / KG 1KG 99% 9000kg/per week Hebei Lingding Biological Technology Co., Ltd

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