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Vardenafil

Vardenafil Structure
Vardenafil structure
CAS No.
224785-90-4
Chemical Name:
Vardenafil
Synonyms
Levitra;VARDENAFIL HCL TRIHYDRATE;FADINAF;Vardenafil powder;Vardenafil (Leviitra);Vivanza;BAY38-9456;VARDENAFIL;Sildelafil;Fardenafil
CBNumber:
CB2321327
Molecular Formula:
C23H32N6O4S
Molecular Weight:
488.6
MDL Number:
MFCD07773094
MOL File:
224785-90-4.mol
Last updated:2024-04-01 18:08:31
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Vardenafil Properties

Melting point 230-235°C
Density 1.37
vapor pressure 0.001Pa at 71.34℃
Flash point 9℃
storage temp. Sealed in dry,Store in freezer, under -20°C
solubility >22.5mg/mL in DMSO
form Powder
pka 9.86±0.20(Predicted)
Water Solubility 7mg/L at 20℃
BCS Class 2
InChIKey NOIHTGOGFDFCBN-UHFFFAOYSA-N
SMILES N12C(CCC)=NC(C)=C1C(=O)N=C(C1=CC(S(N3CCN(CC)CC3)(=O)=O)=CC=C1OCC)N2
LogP 2.5 at 23℃
FDA UNII UCE6F4125H
ATC code G04BE09

Pharmacokinetic data

Protein binding 95%
Excreted unchanged in urine 2-6%
Volume of distribution 208 Litres
Biological half-life 4-5

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictogramsGHS hazard pictograms
GHS02,GHS06,GHS08
Signal word  Danger
Hazard statements  H225-H301+H311+H331-H370
Precautionary statements  P210-P260-P280-P301+P310-P311
Hazard Codes  F,Xn
Risk Statements  11-20/21/22-36
Safety Statements  16-36/37
RIDADR  UN1230 - class 3 - PG 2 - Methanol, solution
WGK Germany  1

Vardenafil price More Price(8)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich V-902 Vardenafil dihydrochloride solution 1.0?mg/mLinmethanol(asfreebase),ampuleof1?mL,certifiedreferencemateri 224785-90-4 1mL $171 2024-03-01 Buy
American Custom Chemicals Corporation API0008769 VARDENAFIL 95.00% 224785-90-4 10MG $255.15 2021-12-16 Buy
AK Scientific E429 Vardenafil 224785-90-4 10mg $98 2021-12-16 Buy
Matrix Scientific 168056 Vardenafil 224785-90-4 1g $472 2021-12-16 Buy
Medical Isotopes, Inc. D34389 Vardenafil-d5HCl 224785-90-4 1mg $675 2021-12-16 Buy
Product number Packaging Price Buy
V-902 1mL $171 Buy
API0008769 10MG $255.15 Buy
E429 10mg $98 Buy
168056 1g $472 Buy
D34389 1mg $675 Buy

Vardenafil Chemical Properties,Uses,Production

Description

Vardenafil is a new PDE5 inhibitor launched for oral treatment of male erectile dysfunction and it has significant structural similarity with sildenafil (Viagra?), which was the first PDE5 inhibitor introduced in 1998 for this indication. Vardenafil is synthesized in three steps starting with a cyclization reaction of 2-ethyoxybenzamidine with 2-butyramidopropionic acid and ethoxyallyl chloride to construct the imidazotriazine ring system, followed by sulfonation to the corresponding sulfonyl chloride and subsequent condensation with 1-ethylpiperazine. The potency of PDE5 inhibition by vardenafil (IC50=0.7 nM) is ～10 times greater than that of sildenafil (IC50=6.6 nM). Vardenafil is typically administered in single doses of 10 and 20 mg. The time to reach maximum plasma concentration is 0.75 h, which is slightly shorter than those of sildenafil (tmax=1.16 h) and tadalafil (tmax=2h), and the half-life is 4–5 h. Although it is almost completely absorbed following oral administration, the mean absolute bioavailability of a 10 mg dose is ～15%, resulting from extensive first pass metabolism. Vardenafil is metabolized in the liver primarily by CYP3A4 and is eliminated mainly in feces. In clinical studies, 10–20 mg doses of vardenafil was well tolerated and efficacious in patients with ED of various severities, including subjects with comorbidities such as diabetes mellitus or hypertension or hyperlipidemia. The side-effect profile of vardenafil is similar to that of sildenafil, with headache, flushing, dyspepsia and nasal congestion being the most common adverse events. Vardenafil has systemic vasodilatory properties, which can cause transient decrease in supine blood pressure; however, it does not appear to translate into clinical effects. The mean maximum decreases in supine systolic blood pressure following 20 and 40 mg vardenafil were 6.9 and 4.3 mmHg, respectively, when compared to placebo. However, single and multiple oral doses of vardenafil up to 40 mg produced no clinically relevant changes in the ECGs of normal male volunteers.

Originator

Bayer AG (Germany)

Uses

erectil dysfunction;PDE5 inhibitor

Uses

Vardenafil Hydrochloride Trihydrate (cas# 330808-88-3) has therapeutic applications and used in cosmetics and personal care products.

Definition

ChEBI: The sulfonamide resulting from formal condensation of the sulfo group of 4-ethoxy-3-(5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(1H)-one-2-yl)benzenesulfonic acid and the secondary amino group of 4-ethylpiperazine.

brand name

Levitra

Flammability and Explosibility

Non flammable

Clinical Use

Treatment of erectile dysfunction

Drug interactions

Potentially hazardous interactions with other drugs
Alpha-blockers: enhanced hypotensive effect - avoid for 6 hours after alpha-blockers (max dose 5 mg).
Antifungals: concentration increased by ketoconazole, and itraconazole - avoid concomitant use.
Antivirals: concentration increased by fosamprenavir, indinavir and ritonavir- avoid with indinavir and ritonavir; increased risk of ventricular arrhythmias with saquinavir - avoid; avoid with telaprevir, use tipranavir with caution.
Cobicistat: concentration of vardenafil possibly increased - reduce dose of vardenafil.
Grapefruit juice: concentration possibly increased - avoid concomitant use.
Nicorandil: possibly enhanced hypotensive effect - avoid concomitant use.
Nitrates: possibly enhanced hypotensive effect - avoid concomitant use.
Riociguat: enhanced hypotensive effect - avoid concomitant use.

Metabolism

Vardenafil is metabolised in the liver primarily by cytochrome P450 isoenzymes CYP3A4 (the major route) as well as CYP3A5 and CYP2C isoforms. The major metabolite produced by desethylation of vardenafil also has some activity.
Vardenafil is excreted as metabolites mainly in the faeces (91 to 95
%), and to a lesser extent in the urine.

Vardenafil synthesis

5308-25-8
224789-21-3
224785-90-4
Synthesis of Vardenafil from 1-Ethylpiperazine and 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE

Vardenafil Preparation Products And Raw materials

Raw materials

4-Ethoxy-3-(5-methyl-4-oxo-7-propyl-3,4-dihydro-imidazo[5,1-f][1,2,4]-triazin-2-yl)benzene-sulfonyl Chloride 2-(2-ETHOXYPHENYL)-5-METHYL-7-PROPYL-3H-IMIDAZOL[5,1-F][1,2,4]-TRIAZIN-4-ONE 1-Ethylpiperazine

Preparation Products

Vardenafil Suppliers

Global( 318)Suppliers
Supplier Tel Email Country ProdList Advantage
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
+86-029-86333380 18829239519 sales06@tgybio.com China 962 58
Firsky International Trade (Wuhan) Co., Ltd
+8615387054039 admin@firsky-cn.com China 436 58
Wuhan Cell Pharmaceutical Co., Ltd
+86-13129979210 +86-13129979210 sales@cellwh.com China 376 58
Wuhan Marco Pharmaceutical Technology Co., Ltd.
+86-86-18572802410 +8618572802410 sales@marcopht.com China 55 58
Wuhan Ruichi Technology Co., Ltd
+8613545065237 admin@whrchem.com China 164 58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
+8619164747840 13119157289@163.com China 2971 58
Dorne Chemical Technology co. LTD 		+86-13583358881 +86-18560316533 Ethan@dornechem.com China 292 58
Shaanxi Franta Biotechnology Co., Ltd 		+86-13082019107 +86-13082019107 admin@flanderff.com China 229 58
Sigma Audley 		+86-18336680971 +86-18126314766 nova@sh-teruiop.com China 524 58
Shanghai Aosiris new Material Technology Co., LTD 		+8615139564871 wrjmoon2000@163.com China 354 58
Supplier Advantage
XI'AN TIANGUANGYUAN BIOTECH CO., LTD.
58
Firsky International Trade (Wuhan) Co., Ltd
58
Wuhan Cell Pharmaceutical Co., Ltd
58
Wuhan Marco Pharmaceutical Technology Co., Ltd.
58
Wuhan Ruichi Technology Co., Ltd
58
Shaanxi Cuikang Pharmaceutical Technology Co., Ltd
58
Dorne Chemical Technology co. LTD 		58
Shaanxi Franta Biotechnology Co., Ltd 		58
Sigma Audley 		58
Shanghai Aosiris new Material Technology Co., LTD 		58

View Lastest Price from Vardenafil manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Vardenafil pictures 2024-04-16 Vardenafil
224785-90-4
 US $1.00 / g 1g 99% 100kg Dorne Chemical Technology co. LTD
Vardenafil pictures 2024-04-12 Vardenafil
224785-90-4
 US $3.00-1.00 / kg 1kg 99.9% 10 tons Shanghai Aosiris new Material Technology Co., LTD
Vardenafil pictures 2024-04-02 Vardenafil
224785-90-4
 US $20.00 / kg 1kg 99 1000kg Shaanxi Franta Biotechnology Co., Ltd
  • Vardenafil pictures
  • Vardenafil
    224785-90-4
  • US $1.00 / g
  • 99%
  • Dorne Chemical Technology co. LTD
  • Vardenafil pictures
  • Vardenafil
    224785-90-4
  • US $3.00-1.00 / kg
  • 99.9%
  • Shanghai Aosiris new Material Technology Co., LTD
  • Vardenafil pictures
  • Vardenafil
    224785-90-4
  • US $20.00 / kg
  • 99
  • Shaanxi Franta Biotechnology Co., Ltd

Vardenafil Spectrum

Vardenafil(224785-90-4)1HNMR

224785-90-4(Vardenafil)Related Search:

Methyl acetate DIETHOXYMETHANE Tadalafil vardenafil Triethylamine hydrochloride
Vardenafil Hydrochloride Trihydrate 224785-90-4 / Bensulfuron methyl Topotecan hydrochloride Methyl acrylate Kresoxim-methyl
Ethyl vinyl ether Ethoxyethyne Citrazinic acid Thiophanate-methyl Ethoxyquin
Trimethylamine hydrochloride Ninhydrin hydrate METSULFURON METHYL Levitra Vardenafil

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VARDENAFIL(SUBJECTTOPATENTFREE) VARDENAFILHYDROCHLORIDETRIHYDRATE(SUBJECTTOPATENTFREE) 2-(2-Ethoxy-5-(4-ethylpiperazin-1-yl-1-sulfonyl)phenyl)-5-methyl-7-propyl-3H-imidazo(5,1-f)(1,2,4)triazin-4-one 1-[[3-(1,4-Dihydro-5-methyl-4-oxo-7-propylimidazo[5,1-f][1,2,4]triazin-2-yl)-4-ethoxyphenyl]sulfonyl]-4-ethyl-piperazine hydrochloride trihydrate 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonyl-phenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one 2-[2-ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one Methanol (test Vardenafil diHCl, 1.0 mg/mL as free base） Vardenafil (Vivanza) Vivanza BAY38-9456 2-(2-ethoxy-5-(4-ethylpiperazin-1-ylsulfonyl)phenyl)-5-methyl-7-propylimidazo[1,5-f][1,2,4]triazin-4(3H)-one hydrochloride trihydrate Zopiclone-D4 solution 2-[2-Ethoxy-5-(4-ethylpiperazin-1-yl)sulfonylphenyl]-5-methyl-7-propyl-1H-imidazo[5,1-f][1,2,4]triazin-4-one hydrochloride Trihydrate VARDENAFIL HYDROCHLORIDE, 98.5-101% VARDENAFIL Vardenafil hydrochloride trihydrate 99% Vardenafil Hydrochloride Trihydrate Cas# 224785-90-4 For Sale Manufacturers Supply best quality Vardenafil hydrochloride trihydrate 224785-90-4 CAS NO.224785-90-4 Vardenafil (Vardenafil hydrochloride salt) Vardenafil Hydrochloride Trihydrate (BAY38-9456) 2-[2-ethoxy-5-(4-ethylpiperazine-1-sulfonyl)phenyl]-5-methyl-7-propyl-1H,4H-imidazo[4,3-f][1,2,4]triazin-4-one hydrochloride Imidazo[5,1-f][1,2,4]triazin-4(1H)-one, 2-[2-ethoxy-5-[(4-ethyl-1-piperazinyl)sulfonyl]phenyl]-5-methyl-7-propyl- Sildelafil Vardenafil white powder Vardenafil hydrochloride trihydrate USP/EP/BP levitra vardenafil 2-(2-Ethoxy-5-((4-ethylpiperazin-1-yl)sulfonyl)phenyl)-5-methyl-7-propylimidazo[5,1-f][1,2,4]triazin-4(3H)-one VardenafilQ: What is Vardenafil Q: What is the CAS Number of Vardenafil Q: What is the storage condition of Vardenafil Q: What are the applications of Vardenafil Levitra VARDENAFIL HCL TRIHYDRATE FADINAF Vardenafil powder Vardenafil (Leviitra) Fardenafil ardenafil hcl trihydrate Valrdenafi Vardenafil hydrochloride trihydrate/Levitra Vardenafil Monomer Vardenafil (free alkali) Vardenafil in methanol Wardenafil Vardenafil CAS 224785-90-4 C23H32N6O4SHCl3H2O C23H32N6O4S C23H39ClN6O7S API Levitra Inhibitor Erectile Dysfunction