N-Hydroxyphthalimide
- CAS No.
- 524-38-9
- Chemical Name:
- N-Hydroxyphthalimide
- Synonyms
- nhpi;2-hydroxyisoindoline-1,3-dione;hydroxyphthalimide;2-hydroxyisoindole-1,3-dione;1H-Isoindole-1,3(2H)-dione, 2-hydroxy-;HOPHT;H-HYDROXY PHTHALIMIDE;2-Hydroxy-1H-isoindole-1,3(2H)-dione;2-hydroxy-2,3-dihydro-1H-isoindole-1,3-dione;f802
- CBNumber:
- CB2332640
- Molecular Formula:
- C8H5NO3
- Molecular Weight:
- 163.13
- MDL Number:
- MFCD00005891
- MOL File:
- 524-38-9.mol
- MSDS File:
- SDS
Melting point | 233 °C (dec.) (lit.) |
---|---|
Boiling point | 290.19°C (rough estimate) |
Density | 1.64 g/cm3 |
vapor pressure | 0Pa at 25℃ |
refractive index | 1.5510 (estimate) |
storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
solubility | DMSO (Slightly), Methanol (Slightly) |
pka | 6.10±0.20(Predicted) |
form | Powder |
color | Yellow |
Water Solubility | Slightly soluble in water. |
Merck | 14,4838 |
BRN | 131208 |
InChIKey | CFMZSMGAMPBRBE-UHFFFAOYSA-N |
LogP | 0.14 |
CAS DataBase Reference | 524-38-9(CAS DataBase Reference) |
FDA UNII | BXI99M81X0 |
EPA Substance Registry System | 1H-Isoindole-1,3(2H)-dione, 2-hydroxy- (524-38-9) |
SAFETY
Risk and Safety Statements
Symbol(GHS) | GHS07 |
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Signal word | Warning | |||||||||
Hazard statements | H335-H315-H319 | |||||||||
Precautionary statements | P264-P280-P302+P352+P332+P313+P362+P364-P305+P351+P338+P337+P313-P261-P280a-P304+P340-P305+P351+P338-P405-P501a | |||||||||
Hazard Codes | Xi | |||||||||
Risk Statements | 36/37/38 | |||||||||
Safety Statements | 26-36-37/39 | |||||||||
WGK Germany | 3 | |||||||||
RTECS | TI5200000 | |||||||||
TSCA | Yes | |||||||||
HazardClass | IRRITANT | |||||||||
HS Code | 29251995 | |||||||||
NFPA 704 |
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N-Hydroxyphthalimide price More Price(51)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H53704 | N-Hydroxyphthalimide 97% | 524-38-9 | 5g | $24.8 | 2024-03-01 | Buy |
Sigma-Aldrich | H53704 | N-Hydroxyphthalimide 97% | 524-38-9 | 100g | $49 | 2024-03-01 | Buy |
TCI Chemical | H0395 | N-Hydroxyphthalimide >99.0%(T) | 524-38-9 | 25g | $17 | 2024-03-01 | Buy |
TCI Chemical | H0395 | N-Hydroxyphthalimide >99.0%(T) | 524-38-9 | 100g | $46 | 2024-03-01 | Buy |
Alfa Aesar | A13862 | N-Hydroxyphthalimide, 98+% | 524-38-9 | 100g | $43.7 | 2024-03-01 | Buy |
N-Hydroxyphthalimide Chemical Properties,Uses,Production
Chemical Properties
N-Hydroxyphthalimide is yellow moist powder
Uses
Catalyst for oxidation reactions.
Uses
Aerobic oxidation of various alcohols has been accomplished by using a new catalytic system, N-hydroxyphthalimide (NHPI) combined with Co (acac). A practical catalytic method to convert alkylbenzenes into the corresponding carboxylic acids under atmospheric dioxygen at ambient temperature using a combined catalytic system consisting of N-hydroxyphthalimide (NHPI) and Co (OAc) 2 was developed. Novel catalysis by N-hydroxyphthalimide in the oxidation of organic substrates by molecular oxygen was described. Free radical functionalization of organic compounds catalyzed by N-hydroxyphthalimide. Purely organic and catalytic systems of anthraquinones and N-hydroxyphthalimide efficiently promote oxygenation of hydrocarbons with dioxygen under mild conditions. Hydroxylation of polycyclic alkanes with molecular oxygen catalyzed by N-hydroxyphthalimide (NHPI) combined with was transition metal salts.
Uses
N-Hydroxyphthalimide,additives in to DCC method of peptide synthesis used to improve yield of optically pure product.
Application
N-Hydroxyphthalimide is used in the synthesis of a new class of antibacterials potent against macrolide resistant bacteria. Also used in the synthesis of pyrazolidines, isoxazolidines and tetrahydrooxazines.
Synthesis Reference(s)
Tetrahedron Letters, 37, p. 2035, 1996 DOI: 10.1016/0040-4039(96)00211-0
Purification Methods
N -Hydroxyphthalimide [524-38-9] M 163.1, m 230o, ~235o(dec), 237-240o, 7.0. Dissolve the imide in H2O by adding Et3N to form the salt and while hot, acidify, cool and pour into a large volume of H2O. Filter off the solid, wash it with H2O and dry it over P2O5 in a vacuum. [Nefken & Teser J Am Chem Soc 83 1263 1961, Fieser 1 485 1976, Nefkens et al. Recl Trav Chim, Pays-Bas 81 683 1962] The O-acetyl derivative has m 178-180o (from EtOH). [Beilstein 21/11 V 100.]
N-Hydroxyphthalimide Preparation Products And Raw materials
Raw materials
1of2
Preparation Products
1of2
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11001 | 58 |
Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
Shanghai Daken Advanced Materials Co.,Ltd | +86-371-66670886 | info@dakenam.com | China | 14764 | 58 |
Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21700 | 55 |
Shanghai Time Chemicals CO., Ltd. | +86-021-57951555 +8617317452075 | jack.li@time-chemicals.com | China | 1807 | 55 |
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
Hefei TNJ Chemical Industry Co.,Ltd. | +86-0551-65418679 +86-18949832763 | info@tnjchem.com | China | 2989 | 55 |
Tianjin Zhongxin Chemtech Co., Ltd. | +86-022-66880623 +8618622897568 | sales@tjzxchem.com | China | 558 | 58 |
career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
Zhejiang ZETian Fine Chemicals Co. LTD | 18957127338 | stella@zetchem.com | China | 2141 | 58 |
View Lastest Price from N-Hydroxyphthalimide manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-01-02 | N-Hydroxyphthalimide
524-38-9
|
US $200.00-2000.00 / KG | 1KG | 0.99 | 20 tons | Zibo Hangyu Biotechnology Development Co., Ltd | ||
2023-09-06 | N-Hydroxyphthalimide
524-38-9
|
US $0.00-0.00 / KG | 1KG | 99% | 500000kg | Hebei Guanlang Biotechnology Co., Ltd. | ||
2023-08-18 | N-Hydroxyphthalimide
524-38-9
|
US $0.00-0.00 / kg | 1kg | 0.99 | 50000kg | Hebei Yibangte Import and Export Co. , Ltd. |
- N-Hydroxyphthalimide
524-38-9
- US $200.00-2000.00 / KG
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
- N-Hydroxyphthalimide
524-38-9
- US $0.00-0.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.
- N-Hydroxyphthalimide
524-38-9
- US $0.00-0.00 / kg
- 0.99
- Hebei Yibangte Import and Export Co. , Ltd.