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7-(2-HYDROXYETHYL)THEOPHYLLINE

7-(2-HYDROXYETHYL)THEOPHYLLINE Structure
7-(2-HYDROXYETHYL)THEOPHYLLINE structure
CAS No.
519-37-9
Chemical Name:
7-(2-HYDROXYETHYL)THEOPHYLLINE
Synonyms
ETOFYLLINE;Etofylline CRS;Oxyethyltheophylline;7-(BETA-HYDROXYETHYL)THEOPHYLLINE;7-(2-Hydroxyethyl)-1,3-dimethyl-3,7-dihydro-1H-purine-2,6-dione;KT 200G;Cordalin;Etofyllin;NSC 113373;Oxyphyllin
CBNumber:
CB2333122
Molecular Formula:
C9H12N4O3
Molecular Weight:
224.22
MDL Number:
MFCD00055055
MOL File:
519-37-9.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:11
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7-(2-HYDROXYETHYL)THEOPHYLLINE Properties

Melting point 163°C
Boiling point 365.61°C (rough estimate)
Density 1.3055 (rough estimate)
refractive index 1.6300 (estimate)
storage temp. Sealed in dry,Room Temperature
solubility H2O: Solutions may be stored for several days at 4°C.soluble
pka 14.48±0.10(Predicted)
form solid
color white
Water Solubility 2.991g/L(temperature not stated)
Merck 14,3878
CAS DataBase Reference 519-37-9(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII L164909TBI

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302
Precautionary statements  P301+P312+P330
Hazard Codes  Xn,Xi
Risk Statements  22-36/37/38
Safety Statements  36-36/37-26
WGK Germany  3
RTECS  XH5850000
HS Code  2939590000
NFPA 704
0
2 0

7-(2-HYDROXYETHYL)THEOPHYLLINE price More Price(33)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich PHR2541 Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material 519-37-9 100MG $508 2024-03-01 Buy
Sigma-Aldrich 1653060 Theophylline Related Compound F United States Pharmacopeia (USP) Reference Standard 519-37-9 25mg $1720 2024-03-01 Buy
Sigma-Aldrich H9006 7-(β-Hydroxyethyl)theophylline solid 519-37-9 25g $104 2023-01-07 Buy
Sigma-Aldrich PHR2588 Theophylline Related Compound F Pharmaceutical Secondary Standard; Certified Reference Material 519-37-9 100MG $443 2022-05-15 Buy
TCI Chemical H0402 7-(2-Hydroxyethyl)theophylline >98.0%(HPLC)(N) 519-37-9 25g $88 2024-03-01 Buy
Product number Packaging Price Buy
PHR2541 100MG $508 Buy
1653060 25mg $1720 Buy
H9006 25g $104 Buy
PHR2588 100MG $443 Buy
H0402 25g $88 Buy

7-(2-HYDROXYETHYL)THEOPHYLLINE Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Duolip,Merckle,W. Germany,1981

Uses

Cardiac analeptic;Phosphodiesterase inhibitor

Uses

Useful synthetic intermediate in the preparation of 7-substituted xanthines.

Uses

An inhibitor of 3’,5’-Cyclic Nucleotide Phosphodiesterase. Therapeutically, this compound has diuretic, muscle relaxant, bronchial dilation and CNS stimulant activities.

Definition

ChEBI: 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione is an oxopurine.

Manufacturing Process

107.3 g (0.5 mol) 2-(p-chlorophenoxy)isobutyric acid and 56.0 g (0.25 mol) 7-hydroxyethyltheophylline were suspended together in 250 ml xylene. They were heated together for 15 hours in a water separator following the addition of 1.5 g p-toluenesulfonic acid. The solution was next agitated with dilute sodium bicarbonate solution (0.5 mol NaHCO3), water washed and evaporated in a rotary evaporator.
The residue was then crystallized from isopropanol, yielding 58.0 g (55% yield) of 1-(7-theophyllinyl)-2-ethyl[2-(p-chlorophenoxy)-isobutyrate] . The compound had a melting point of 131°C to 132°C.

Therapeutic Function

Antihyperlipidemic

Biochem/physiol Actions

Pharmacological profile similar to theophylline.

7-(2-HYDROXYETHYL)THEOPHYLLINE Preparation Products And Raw materials

Raw materials

2-(4-Chlorophenoxy)-2-methylpropionic acid

Preparation Products

2-(1,2,3,6-tetrahydro-1,3-dimethyl-2,6-dioxo-7H-purin-7-yl)ethyl nicotinate 1H-Purine-2,6-dione, 7-[2-(acetyloxy)ethyl]-3,7-dihydro-1,3-dimethyl-

7-(2-HYDROXYETHYL)THEOPHYLLINE Suppliers

Global( 212)Suppliers
Supplier Tel Email Country ProdList Advantage
Capot Chemical Co.,Ltd. 		571-85586718 +8613336195806 sales@capotchem.com China 29797 60
Hubei Jusheng Technology Co.,Ltd. 		18871490254 linda@hubeijusheng.com CHINA 28180 58
Standardpharm Co. Ltd. 		86-714-3992388 overseasales1@yongstandards.com United States 14336 58
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Aston Chemical 		13000000000 sales@astonchem.com United States 1634 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Alfa Chemistry 		+1-5166625404 Info@alfa-chemistry.com United States 21317 58
Supplier Advantage
Capot Chemical Co.,Ltd. 		60
Hubei Jusheng Technology Co.,Ltd. 		58
Standardpharm Co. Ltd. 		58
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
AFINE CHEMICALS LIMITED 		58
Aston Chemical 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Alfa Chemistry 		58

View Lastest Price from 7-(2-HYDROXYETHYL)THEOPHYLLINE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
7-(2-Hydroxyethyl)theophylline pictures 2020-02-02 7-(2-Hydroxyethyl)theophylline
519-37-9
 US $1.00 / KG 1KG Min98%HPLC g/kg/ton Career Henan Chemical Co

7-(2-HYDROXYETHYL)THEOPHYLLINE Spectrum

7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)MS7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)1HNMR7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)13CNMR7-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)IR17-(2-HYDROXYETHYL)THEOPHYLLINE(519-37-9)IR2

519-37-9(7-(2-HYDROXYETHYL)THEOPHYLLINE)Related Search:

Tazifylline PROXYPHYLLINE Theophylline-7-acetic acid Diprophylline Doxofylline
Xanthinol nicotinate ETOFYLLINE CLOFIBRATE 7-(2-HYDROXYETHYL)THEOPHYLLINE Theophylline 1,3-DIMETHYL-7-(OXIRAN-2-YLMETHYL)-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
8-CHLORO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 8-BROMO-7-[2-(4-CHLOROPHENOXY)ETHYL]-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE ETHYL 2-(8-CHLORO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-MORPHOLINO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE
ETHYL 2-(8-BROMO-1,3-DIMETHYL-2,6-DIOXO-2,3,6,7-TETRAHYDRO-1H-PURIN-7-YL)ACETATE 8-BROMO-7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE 7-(3-CHLORO-2-HYDROXYPROPYL)-1,3-DIMETHYL-8-NITRO-2,3,6,7-TETRAHYDRO-1H-PURINE-2,6-DIONE

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ETOFYLLINE EPE(CRM STANDARD) ETOFYLLINE MM(CRM STANDARD) 7-(2-HYDROXYETHYL)THEOPHYLLINE 98+% ETOFYLLINE (BETA-HYDROXYETHYLTHEOPHYLLINE) Phyllocormin BETA-HYDROXYETHYLTHEOPHYLLINE BIOPHYLLINE THEOPHYLLINE, 7-(BETA-HYDROXYETHYL) 7-(2-hydroxyethyl)-1,3-dimethyl-purine-2,6-dione 7-(2-hydroxyethyl)-1,3-dimethylpurine-2,6-dione KT 200G NSC 113373 Oxyethophylline Oxyphyllin 7-(2-Hydroxyethyl)-1,3-diMethyl-3,7-dihydro-1H-purine-2,6-dione,97% 7-(2-Hydroxyethyl)-1,3-dimethyl-1H-purine-2,6(3H,7H)-dione Theophylline Related Compound F 7-(A-HYDROXYETHYL)THEOPHYLLINE 7-(2-HYDROXYETHYL)THEOPHYLLINE 1,3-DIMETHYL-7-(BETA-HYDROXYETHYL)XANTHINE 1,3-DIMETHYL-7-[2-HYDROXYETHYL]-XANTHINE 1H-Purine-2,6-dione, 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl- 3,7-Dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1H-purine-2,6-dione 3,7-dihydro-7-(2-hydroxyethyl)-1,3-dimethyl-1h-purine-6-dione oxphylline(amido) Oxyaethyltheophyllin Oxyphylline Oxytheonyl Phyllocormin N phyllocorminn Sklerodormal Soluphylline Theophylline, 7-(2-hydroxyethyl)- 7-(Hydroxyethyl)theophylline 7-Theophyllineethanol Aethophyllinum Ascorphylline b-hydroxyethyltheophylline Cordalin Corophyllin-N Dilaphyllin Frekaphyllin Hydroxyethyl theophyline Hydroxyethyltheophylline Oxphylline Oxphylline (Amido) 7-(2-Hydroxyethyl)-1,3-dimethylxanthine 7-(2-hydroxyethyl)-theophyllin Theophylline EP Impurity F Etofyllin Diprophylline Impurity 3（Diprophylline EP Impurity C） Theophylline-ethylenediamine Impurity 6（Theophylline-ethylenediamine EP Impurity F） Diprophylline EP Impurity C Hydroxuethyl theophylline 7-(2-Hydroxyethyl)theophylline> 7-(β-Hydroxyethyl)theophylline β-hydroxyethyltheophylline EtofyllineQ: What is Etofylline Q: What is the CAS Number of Etofylline Q: What is the storage condition of Etofylline Q: What are the applications of Etofylline