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(R)-5,7-difluorochroman-4-ol

(R)-5,7-difluorochroman-4-ol structure

CAS No.: 1270294-05-7

Chemical Name:: (R)-5,7-difluorochroman-4-ol

Synonyms: (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol;Tegoprazan Impurity 11;R-5,7-difluorobenzo dihydropyran-4-ol;Tegoprazan Impurity;Tegoprazan side chain;Tegoprazan ImpuritiesC;Tigora produced impurity 11;(R)-5, 7-difluorobenzopyrane-4-ol;(R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate;2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)-

CBNumber:: CB23354564

Molecular Formula:: C9H8F2O2

Molecular Weight:: 186.16

MDL Number:: MFCD09763634

MOL File:: 1270294-05-7.mol

MSDS File:: SDS

Last updated:2026-03-17 17:48:12

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(R)-5,7-difluorochroman-4-ol Properties

Boiling point	228.4±40.0 °C(Predicted)
Density	1.402±0.06 g/cm3(Predicted)
storage temp.	Storage temp. 2-8°C
pka	13.09±0.20(Predicted)
Appearance	White to off-white Solid
InChI	InChI=1S/C9H8F2O2/c10-5-3-6(11)9-7(12)1-2-13-8(9)4-5/h3-4,7,12H,1-2H2/t7-/m1/s1
InChIKey	HGTYMLFMXKYIQW-SSDOTTSWSA-N
SMILES	C1OC2=CC(F)=CC(F)=C2[C@H](O)C1

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302-H315-H319-H335
Precautionary statements	P261-P305+P351+P338

(R)-5,7-difluorochroman-4-ol Chemical Properties,Uses,Production

Uses

(R)-5,7-difluorochroman-4-ol is an important intermediate in the synthesis of tegoprazan[1].

Production Methods

Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol, where ketoreductase is one or combination of two or more of short-chain dehydrogenases/reductases family (SDR), medium-chain dehydrogenases/reductase (MDR) or aldo-Keto reductase (AKR)[1].

References

[1]PAN X, et al. "Preparing (R)-5,7-difluorochroman-4-ol involves taking 5, 7-difluorochroman-4-one as substrate, and performing asymmetric reduction reaction in the presence of ketoreductase, coenzyme and coenzyme circulating system to obtain (R)-5,7-difluorochroman-4-ol.", CN202210486605.0. 2022.

(R)-5,7-difluorochroman-4-ol Preparation Products And Raw materials

Raw materials

1-BROMO-4-CHLORO-1,1,2,2-TETRAFLUOROBUTANE 5,7-difluorochroman-4-one

Preparation Products

(R)-5,7-difluorochroman-4-ol Suppliers

Global( 163)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou ICH Biofarm Co., Ltd	+86-0571-28186870; +undefined8613073685410	sales@ichemie.com	China	1006	58
Joyochem Co.,Ltd	+86-0531-82687998 +8615153169511	sales01@joyochem.com	China	30	58
ChemExpress	+86-19370970350 +86-021-58950125	info@chemexpress.com	China	788	58
Zhengzhou Anbu Chem Co.,Ltd	+86-0371-88006763; +8615988602810	sales@anbuchem.com	China	3015	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	+86-13017695106 +86-13676922317	jiuyitime@fdachem.com	China	16513	58
Shanghai Daken Advanced Materials Co.,Ltd	+86-2158073036	info@dakenam.com	China	13843	58
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10404	58
Shanghai Worldyang Chemical Co.,Ltd.	+86-021-56795779 +8613651600618	sales@worldyachem.com	China	967	58
CONIER CHEM AND PHARMA LIMITED	+8618523575427	sales@conier.com	China	49977	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	+86-021-61551413 +8618813727289	contact@trustwe.com	China	5742	58

Supplier	Advantage
Hangzhou ICH Biofarm Co., Ltd	58
Joyochem Co.,Ltd	58
ChemExpress	58
Zhengzhou Anbu Chem Co.,Ltd	58
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD	58
Shanghai Daken Advanced Materials Co.,Ltd	58
Shenzhen Nexconn Pharmatechs Ltd	58
Shanghai Worldyang Chemical Co.,Ltd.	58
CONIER CHEM AND PHARMA LIMITED	58
SHANGHAI T&W PHARMACEUTICAL CO., LTD.	58

View Lastest Price from (R)-5,7-difluorochroman-4-ol manufacturers

Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
2026-04-17	(R)-5,7-difluorochroman-4-ol 1270294-05-7	US $2.00-5.00 / kg	1kg	99%	100kg	ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD
2026-03-17	(R)-5,7-difluorochroman-4-ol 1270294-05-7	US $0.00-0.00 / kg	1kg	99%	1 ton	Hangzhou Verychem Science And Technology Co.Ltd
2026-01-04	(R)-5,7-difluorochroman-4-ol 1270294-05-7	US $0.00-0.00 / kg	0.1kg	99.0%min	2000kg	Hangzhou ICH Biofarm Co., Ltd

(R)-5,7-difluorochroman-4-ol
1270294-05-7
US $2.00-5.00 / kg
99%
ZHENGZHOU JIUYI TIME NEW MATERIALS CO,.LTD

(R)-5,7-difluorochroman-4-ol
1270294-05-7
US $0.00-0.00 / kg
99%
Hangzhou Verychem Science And Technology Co.Ltd

(R)-5,7-difluorochroman-4-ol
1270294-05-7
US $0.00-0.00 / kg
99.0%min
Hangzhou ICH Biofarm Co., Ltd

(R)-5,7-difluorochroman-4-ol Spectrum

(R)-5,7-difluorochroman-4-ol(1270294-05-7)¹HNMR

1270294-05-7((R)-5,7-difluorochroman-4-ol)Related Search:

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(Dimethylamino)acetaldehyde Dimethyl Acetal 2-Aminobiphenyl 1-(piperidine-4-carbonyl)piperidine-4-carboxylic acid hydrochloride Butanedioic acid, 2-[[2-methyl-1-(phenylmethyl)-1H-imidazol-5-yl]methylene]-, 1-ethyl ester, (2E)- 1H-Benzimidazole-6-carboxamide, 4-hydroxy-N,N,2-trimethyl-1-(phenylmethyl)-

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1of3

2H-1-Benzopyran-4-ol, 5,7-difluoro-3,4-dihydro-, (4R)- Tegoprazan Impurity 11 R-5,7-difluorobenzo dihydropyran-4-ol (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol [2-(2-chlorophenyl)ethanamine, 1-Amino-2-(2-chlorophenyl)ethane, 2-(2-Chlorophenyl)ethylamine] (R)-5, 7-difluorobenzopyrane-4-ol Tegoprazan side chain Tegoprazan ImpuritiesC Tegoprazan Impurity Tigora produced impurity 11 (4R)-5,7-difluoro-3,4-dihydro-2H-1-benzopyran-4-ol - [D82158] (R)-5,7-Difluorochroman-4-ol ，Tegoprazan intermdiate 1270294-05-7 API