N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- CAS No.
- 1052147-86-0
- Chemical Name:
- N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide
- Synonyms
- LP21;LP-211;LP-211 >=98% (HPLC);LP-211; LP 211; LP211;1052147-86-0;N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide;1-Piperazinehexanamide, 4-[1,1'-biphenyl]-2-yl-N-[(4-cyanophenyl)methyl]-;LP 211,Inhibitor,5-HT Receptor,Serotonin Receptor,LP-211,5-hydroxytryptamine Receptor,LP211,inhibit
- CBNumber:
- CB23385434
- Molecular Formula:
- C30H34N4O
- Molecular Weight:
- 466.62
- MDL Number:
- MFCD22690843
- MOL File:
- 1052147-86-0.mol
- MSDS File:
- SDS
| Boiling point | 714.8±60.0 °C(Predicted) |
|---|---|
| Density | 1.17±0.1 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility |
DMSO:100.0(Max Conc. mg/mL);214.3(Max Conc. mM) Ethanol:50.0(Max Conc. mg/mL);107.15(Max Conc. mM) |
| pka | 15.39±0.46(Predicted) |
| form | solid |
| color | clear white to light brown |
| FDA UNII | NCS2VAH93R |
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide price More Price(16)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1561 | LP-211 ≥98% (HPLC) | 1052147-86-0 | 5MG | $131 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1561 | LP-211 ≥98% (HPLC) | 1052147-86-0 | 25MG | $530 | 2023-06-20 | Buy |
| Cayman Chemical | 29659 | LP-211 | 1052147-86-0 | 5mg | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 29659 | LP-211 | 1052147-86-0 | 25mg | $131 | 2024-03-01 | Buy |
| Cayman Chemical | 29659 | LP-211 ≥98% | 1052147-86-0 | 50mg | $243 | 2024-03-01 | Buy |
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Chemical Properties,Uses,Production
Uses
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor used in pharmacological studies which showed that it underwent metabolic breakdown to RA-7 and showed pharmacological activities such as induced hypothermia in mice and showed optimal pharmacokinetics in rats.LP-211 is also a drug analogue of piperazinehexanamide exhibiting 5-HT7 receptor affinity.
Biochem/physiol Actions
LP-211 is a brain penetrant selective agonist for the serotonin 5-HT7 receptor with a Ki value of 0.58 nM at rat cloned 5-HT7 receptors, and >300-fold selectivity over the 5-HT1A receptor. The 5-HT7 receptor is involved in a variety of central nervous system functions including circadian rhythm, sleep, thermoregulation, nociception, and memory, and appears to be involved in cognitive disorders, anxiety, and depression. LP-211 has been used as a selective 5-HT7 receptor agonist in multiple models including studies as a potential therapeutic agent in models of Rett syndrome and Fragile X Syndrome.
N-(4-cyanophenylmethyl)-4-(2-diphenyl)-1-piperazinehexanamide Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
| InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
| LEAP CHEM CO., LTD. | +86-852-30606658 | market18@leapchem.com | China | 24738 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
| Shanghai Lollane Biological Technology Co.,Ltd. | 021-52996696，15000506266 15000506266 | China | 4121 | 55 | |
| Shanghai YuanYe Biotechnology Co., Ltd. | 021-61312847; 18021002903 | 3008007409@qq.com | China | 27322 | 60 |
| ShangHai Biochempartner Co.,Ltd | 17754423994 17754423994 | 2853530910@QQ.com | China | 8011 | 62 |