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COUMESTROL

COUMESTROL structure

CAS No.: 479-13-0

Chemical Name:: COUMESTROL

Synonyms: Nsc22842;Cumostrol;Cumoestrol;COUMESTROL;COUMOESTROL;cumoesterol;Coumesterol;COUMESTROL(P);Coumestrol,99%;Coumestrol, >98%

CBNumber:: CB2339816

Molecular Formula:: C15H8O5

Molecular Weight:: 268.22

MDL Number:: MFCD00016885

MOL File:: 479-13-0.mol

Last updated:2023-09-04 15:51:00

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COUMESTROL Properties

Melting point	≥350 °C(lit.)
Boiling point	331.39°C (rough estimate)
Density	1.2586 (rough estimate)
refractive index	1.7680 (estimate)
storage temp.	Refrigerator
solubility	DMSO: soluble
form	Light beige solid.
pka	8.25±0.20(Predicted)
color	Pale Yellow to Dark Brown
BRN	266702
LogP	2.940 (est)
CAS DataBase Reference	479-13-0(CAS DataBase Reference)
NCI Dictionary of Cancer Terms	coumestrol
FDA UNII	V7NW98OB34
EPA Substance Registry System	Coumestrol (479-13-0)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS07

Signal word

Warning

Hazard statements

H302-H315-H319-H335

Precautionary statements

P261-P264-P270-P301+P312-P302+P352-P305+P351+P338

Hazard Codes

Risk Statements

22-36/37/38

Safety Statements

26-36

WGK Germany

RTECS

DF8077000

NFPA 704

	0
2		0

COUMESTROL price More Price(24)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	27883	Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	479-13-0	1mg	$97.2	2024-03-01	Buy
Sigma-Aldrich	27883	Coumestrol BioReagent, suitable for fluorescence, ≥97.5% (HPLC)	479-13-0	5mg	$321	2024-03-01	Buy
Cayman Chemical	11730	Coumestrol ≥98%	479-13-0	1mg	$44	2024-03-01	Buy
Cayman Chemical	11730	Coumestrol ≥98%	479-13-0	5mg	$93	2024-03-01	Buy
Sigma-Aldrich	27885	Coumestrol ≥95.0% (HPLC)	479-13-0	50mg	$386	2024-03-01	Buy

Product number	Packaging	Price	Buy
27883	1mg	$97.2	Buy
27883	5mg	$321	Buy
11730	1mg	$44	Buy
11730	5mg	$93	Buy
27885	50mg	$386	Buy

COUMESTROL Chemical Properties,Uses,Production

Description

Coumestrol is a phytoestrogen that occurs naturally in soybeans, spinach, and clover. It competitively (vs. 17β-estradiol, ) binds the estrogen receptors ERα (IC₅₀ = 11 nM) and ERβ (IC₅₀ = 2 nM) and can induce ER-dependent gene expression in isolated cells. Coumestrol is also a weak antagonist of pregnane X receptor (IC₅₀ = 12 μM) as well as a potential inverse agonist of the constitutive androstane receptor (EC₅₀ = 30 μM).

Chemical Properties

Yellow to Beige Powder

Uses

This compound has estrogenic activity. It exhibits bright blue fluorescence in neutral or acid solution, and greenish-yellow fluorescence in strong alkali solution.

Definition

ChEBI: A member of the class of coumestans that is coumestan with hydroxy substituents at positions 3 and 9.

Synthesis Reference(s)

Tetrahedron Letters, 4, p. 1151, 1963 DOI: 10.1039/jr9630005127

Biochem/physiol Actions

Coumestrol has anti-estrogenic actions in the brain and pituitary, mediated through estrogen receptor-α.

Safety Profile

An experimental teratogen. Other experimental reproductive effects. Mutation data reported. When heated to decomposition it emits acrid smoke and irritating fumes.

References

[1]. chen hy, dykstra kd, birzin et, et al. estrogen receptor ligands. part 1: the discovery of flavanoids with subtype selectivity. bioorg med chem lett. 2004 mar 22;14(6):1417-21.
[2]. hopert ac, beyer a, frank k, et al. characterization of estrogenicity of phytoestrogens in an endometrial-derived experimental model. environ health perspect. 1998 sep;106(9):581-6.
[3]. wang h, li h, moore lb, et al. the phytoestrogen coumestrol is a naturally occurring antagonist of the human pregnane x receptor. mol endocrinol. 2008 apr;22(4):838-57.

COUMESTROL Preparation Products And Raw materials

Raw materials

Preparation Products

COUMESTROL Suppliers

Global( 143)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei xin bonus chemical co. LTD	86-13657291602	linda@hubeijusheng.com	CHINA	22968	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
Shaanxi Dideu Medichem Co. Ltd	+86-29-87569265 +86-18612256290	1056@dideu.com	China	3683	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Neostar United (Changzhou) Industrial Co., Ltd.	+86-519-519-85557386	marketing1@neostarunited.com	China	8349	58
Wuhan ChemNorm Biotech Co.,Ltd.	+86-27-8439 4403 18971486879	sales@chemnorm.com	CHINA	2935	58
Finetech Industry Limited	+86-27-87465837 +8618971612321	info@finetechnology-ind.com	China	9702	58
sgtlifesciences pvt ltd	+8617013299288	dj@sgtlifesciences.com	China	12382	58

Supplier	Advantage
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Hubei xin bonus chemical co. LTD	58
Chongqing Chemdad Co., Ltd	58
Shaanxi Dideu Medichem Co. Ltd	58
Antai Fine Chemical Technology Co.,Limited	58
Neostar United (Changzhou) Industrial Co., Ltd.	58
Wuhan ChemNorm Biotech Co.,Ltd.	58
Finetech Industry Limited	58
sgtlifesciences pvt ltd	58

View Lastest Price from COUMESTROL manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-20	CouMestrol 479-13-0	US $0.00-0.00 / KG	5mg	99%HPLC	2000tons	Shaanxi Dideu Medichem Co. Ltd
	2019-07-06	COUMESTROL 479-13-0	US $1.00 / KG	1g	99%	100KG	Career Henan Chemical Co

CouMestrol
479-13-0
US $0.00-0.00 / KG
99%HPLC
Shaanxi Dideu Medichem Co. Ltd

COUMESTROL
479-13-0
US $1.00 / KG
99%
Career Henan Chemical Co

COUMESTROL Spectrum

COUMESTROL(479-13-0)¹HNMR

479-13-0(COUMESTROL)Related Search:

BAVACHININ A 8-Prenyldaidzein 1-[2-Hydroxy-4-methoxy-5-(3-methyl-2-butenyl)phenyl]-3-(4-hydroxyphenyl)-2-propen-1-one 7-Bromo-2-(4-hydroxyphenyl)-1,3-benzoxazol-5-ol WEDELOLACTONE

psoralidin 3-HYDROXY-8,9-METHYLENEDIOXYCOUMESTAN COUMESTROL demethylwedelolactone 3-HYDROXY-9-METHOXYCOUMESTAN

neoglycyrol COUMESTROL DIMETHYL ETHER,COUMESTROL DIMETHYL ETHER, FOR FLUORESCE 4'-ORTHO-METHYL-COUMESTROL COUMESTROL DIACETATE MEDICAGO COUMESTROL 10%

COUMESTROL(RG) COUMESTROL DIACETATE, FOR FLUORESCENCE* TRIFOLIOL

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cumoesterol COUMOESTROL 7 12-DIHYDROXYCOUMESTAN 98% Coumesterol COUMESTROL(P) 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE 98% Coumestrol,99% 3-Benzofurancarboxylic acid, 2-(2,4-dihydroxyphenyl)-6-hydroxy-, .delta.-lactone 6H-Benzofuro[3,2-C][1]benzopyran-6-one, 3,9-dihydroxy- Cumoestrol Cumostrol Nsc22842 2-(2,4-Dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylic Acid δ-Lactone 7,12-DIHYDROXYCOUMESTAN 7,12-DIHYDROXYCOUMESTANE 7(1), 6-DIHYDROXYCOUMARINO(3(1), 4(1), 3,2)COUMARONE [2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURAN-CARBOXYLIC ACID ALPHA-LACTONE] 2-(2,4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID DELTA-LACTONE 2-(2 4-DIHYDROXYPHENYL)-6-HYDROXY-3-BENZOFURANCARBOXYLIC ACID D-LACTONE COUMESTROL COUMESTROL BIOREAGENT, SUITABLE FOR 3,9-Dihydroxy-6H-[1]benzofuro[3,2-c]chromen-6-one 3,9-DIHYDROXY-6H-BENZOFURO[3,2-C]-[1]BENZOPYRAN-6-ONE 2-(2,4-dihydroxyphenyl)-6-hydroxy-3-benzofurancarboxylicacidelta-lacton 2-c)(1)benzopyran-6-one,3,9-dihydroxy-6h-benzofuro( 2-c][1]benzopyran-6-one,3,9-dihydroxy-6h-benzofuro[ Coumestrol, >98% 3,9-dihydroxy-6-benzofuro[3,2-c][1]benzopyranone Coumestrol ( synthitic) 7’, 6-DIHYDROXYCOUMARINO(3’, 4’, 3, 2)COUMARONE 3,9-Dihydroxy-6H-benzofuro[3,2-c]chromen-6-one Coumestrol (Synthetic) 479-13-0 C15H9O5 C15H8O5 Steroids & Hormones - 13C & 2H Steroids Coumarins Iso-Flavones