Bergamotine
- CAS No.
- 7380-40-7
- Chemical Name:
- Bergamotine
- Synonyms
- BERGAMOTTIN;BERGAPTIN;BERGAMOTIN;GF-I-2;p190-B;ARHGAP5;RhoGAP5;Bergaptine;AKOS 214-13;BERGAMOTINE
- CBNumber:
- CB2342865
- Molecular Formula:
- C21H22O4
- Molecular Weight:
- 338.4
- MDL Number:
- MFCD00017409
- MOL File:
- 7380-40-7.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Bergamottin analytical standard | 01338 | 5mg | $203 |
| Bergamottin ≥98% | 10009439 | 1mg | $36 |
| Bergamottin ≥98% | 10009439 | 5mg | $153 |
| Bergamottin ≥98% | 10009439 | 10mg | $268 |
| Bergamottin ≥98% | 10009439 | 1mg | $32 |
| More product size | |||
| Melting point | 75-80 °C |
|---|---|
| Boiling point | 503.7±50.0 °C(Predicted) |
| Density | 1.153±0.06 g/cm3(Predicted) |
| storage temp. | 2-8°C |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| color | White to Pale Yellow |
| BRN | 1353914 |
| Major Application | food and beverages |
| InChI | 1S/C21H22O4/c1-14(2)5-4-6-15(3)9-11-24-21-16-7-8-20(22)25-19(16)13-18-17(21)10-12-23-18/h5,7-10,12-13H,4,6,11H2,1-3H3/b15-9+ |
| InChIKey | DBMJZOMNXBSRED-OQLLNIDSSA-N |
| SMILES | C\C(C)=C\CC\C(C)=C\COc1c2C=CC(=O)Oc2cc3occc13 |
| LogP | 5.382 (est) |
| FDA UNII | JMU611YFRB |
| UNSPSC Code | 85151701 |
| NACRES | NA.24 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|---|---|
| Signal word | Warning |
| Hazard statements | H315-H319 |
| Precautionary statements | P264-P280-P302+P352-P337+P313-P305+P351+P338-P362+P364-P332+P313 |
| PPE | Eyeshields, Gloves, type N95 (US) |
| Safety Statements | 22-24/25 |
| WGK Germany | 3 |
| F | 10-23 |
| Storage Class | 11 - Combustible Solids |
Bergamotine price More Price(24)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 01338 | Bergamottin analytical standard | 7380-40-7 | 5mg | $203 | 2026-04-30 | Buy |
| Cayman Chemical | 10009439 | Bergamottin ≥98% | 7380-40-7 | 1mg | $36 | 2026-04-30 | Buy |
| Cayman Chemical | 10009439 | Bergamottin ≥98% | 7380-40-7 | 5mg | $153 | 2026-04-30 | Buy |
| Cayman Chemical | 10009439 | Bergamottin ≥98% | 7380-40-7 | 10mg | $268 | 2026-04-30 | Buy |
| Cayman Chemical | 10009439 | Bergamottin ≥98% | 7380-40-7 | 1mg | $32 | 2024-03-01 | Buy |
Bergamotine Chemical Properties,Uses,Production
Chemical Properties
White needle-shaped crystals, soluble in organic solvents such as methanol, ethanol, DMSO, etc., with the highest content coming from lemon pulp, including Northern Adenophora and Notopterygium wilfordii.
Uses
Bergamottin (BG), a component of grapefruit juice, is a mechanism-based inactivator of CYP3A4 and contributes, in part, to the grapefruit juice-drug interaction.
Definition
ChEBI: A natural product found in Citrus hystrix.
in vivo
The anticancer efficacy of Bergamottin under in vivo conditions using female BALB/c nude mice (a total of 20 mice are used) is determined. Tumors are induced in the mice by injecting non-small cell lung cancer A549 cells (1×106 cells/mouse). After tumor formation, the mice are sacrificed and tumors are removed and their weights and volumes are calculated. The results show that 25, 50 and 100 mg/kg Bergamottin injection reduce the tumor weight from 1.61 g in the PBS-treated group (control) to 1.21, 0.42 and 0.15 g, respectively. Tumor weight in the nude mice is reduced much more significantly in the highest-concentration Bergamottin group (100 mg/kg body weight) compared with the vehicle group (P<0.05). Likewise, 25, 50 and 100 mg/kg Bergamottin injection reduces the tumor volume from 2.2 cm3 in the PBS-treated group (control) to 1.71, 1.1 and 0.51 cm3, respectively. The periodic measurement of the tumor xenograft volume indicates that the tumor volume in the nude mice is reduced considerably in the highest-concentration Bergamottin group (100 mg/kg body weight) compared with the vehicle group (P<0.05)[2].
IC 50
CYP1A1: 10.703 nM (Ki); CYP1A1: 0.192 μM (IC50); CYP1A2: 5.077 μM (IC50); CYP2B2: 4.535 μM (IC50); CYP2B1: 9.495 μM (IC50)
Bergamotine Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shanghai Zheyan Biotech Co., Ltd. | 18017610038 | zheyansh@163.com | CHINA | 3619 | 58 |
| Chengdu Greenpure Biopharma CO.,Ltd | 18283602253; +8618283602253 | jancyzheng@gcgreenpure.com | China | 954 | 58 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29819 | 58 |
| Chengdu GLP biotechnology Co Ltd | 028-87075086 13350802083 | scglp@glp-china.com | CHINA | 1824 | 58 |
| Chengdu Biopurify Phytochemicals Ltd. | +86-28-82633860; +8618080483897 | sales@biopurify.com | China | 3751 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19552 | 58 |
| Shanghai Standard Technology Co., Ltd. | 18502101150 | ft-sales@nature-standard.com | CHINA | 1923 | 58 |
| Antai Fine Chemical Technology Co.,Limited | 18503026267 | info@antaichem.com | CHINA | 9636 | 58 |
| Wuhan ChemNorm Biotech Co.,Ltd. | +86-27-8439 4403 18971486879 | sales@chemnorm.com | CHINA | 2935 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10236 | 58 |
View Lastest Price from Bergamotine manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2023-02-24 | Bergamotine
7380-40-7
|
US $0.00 / mg | 5mg | ≥98%(HPLC) | 10 g | Shanghai Standard Technology Co., Ltd. | |
 |
2019-07-06 | Bergamotine
7380-40-7
|
US $1.00 / KG | 1g | 99% | 100KG | Career Henan Chemical Co |
-
- Bergamotine
7380-40-7
- US $0.00 / mg
- ≥98%(HPLC)
- Shanghai Standard Technology Co., Ltd.
-
- Bergamotine
7380-40-7
- US $1.00 / KG
- 99%
- Career Henan Chemical Co
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