Hydantoin
- CAS No.
- 461-72-3
- Chemical Name:
- Hydantoin
- Synonyms
- Imidazolidine-2,4-dione;2,4-IMIDAZOLIDINEDIONE;Maine;NSC 922;NSC 9226;HYDANTOIN;GLYCOLYLUREA;Hydantoin>glycollylurea;Hydantoin,99%
- CBNumber:
- CB2352752
- Molecular Formula:
- C3H4N2O2
- Molecular Weight:
- 100.08
- MDL Number:
- MFCD00005259
- MOL File:
- 461-72-3.mol
- MSDS File:
- SDS
- TDS File:
- TDS
| Product description | Number | Pack Size | Price |
| Hydantoin 98% | 156361 | 100g | $45.8 |
| Hydantoin for synthesis | 8.04511 | 500g | $147 |
| Hydantoin 98% | 156361 | 500g | $134 |
| Hydantoin for synthesis | 8.04511 | 100g | $40.6 |
| Hydantoin >99.0%(T) | H0167 | 25g | $31 |
| More product size | |||
| Melting point | 218-220 °C (lit.) |
|---|---|
| Boiling point | 187.47°C (rough estimate) |
| Density | 1.4457 (rough estimate) |
| vapor pressure | 0Pa at 25℃ |
| refractive index | 1.5110 (estimate) |
| storage temp. | Store below +30°C. |
| solubility | SLIGHTLY SOLUBLE |
| pka | pKa 9.1 (Uncertain) |
| form | Fine Powder |
| color | White to light yellow |
| Water Solubility | SLIGHTLY SOLUBLE |
| Merck | 14,4760 |
| BRN | 110598 |
| InChI | 1S/C3H4N2O2/c6-2-1-4-3(7)5-2/h1H2,(H2,4,5,6,7) |
| InChIKey | WJRBRSLFGCUECM-UHFFFAOYSA-N |
| SMILES | O=C1CNC(=O)N1 |
| LogP | -1.69 |
| CAS DataBase Reference | 461-72-3(CAS DataBase Reference) |
| EWG's Food Scores | 1 |
| FDA UNII | I6208298TA |
| NIST Chemistry Reference | 2,4-Imidazolidinedione(461-72-3) |
| EPA Substance Registry System | 2,4-Imidazolidinedione (461-72-3) |
| UNSPSC Code | 12352115 |
| NACRES | NA.22 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H315-H319-H335 | |||||||||
| Precautionary statements | P264-P280-P302+P352-P321-P332+P313-P362-P264-P280-P305+P351+P338-P337+P313P | |||||||||
| PPE | Eyeshields, Gloves, type N95 (US) | |||||||||
| Hazard Codes | Xi | |||||||||
| Risk Statements | 36/37/38 | |||||||||
| Safety Statements | 24/25-36/37/39-27-26 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | MT8210000 | |||||||||
| TSCA | TSCA listed | |||||||||
| HS Code | 29332100 | |||||||||
| Storage Class | 11 - Combustible Solids | |||||||||
| REACH Registrations | Inactive | |||||||||
| NFPA 704 |
|
Hydantoin price More Price(59)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 156361 | Hydantoin 98% | 461-72-3 | 100g | $45.8 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.04511 | Hydantoin for synthesis | 461-72-3 | 500g | $147 | 2026-04-30 | Buy |
| Sigma-Aldrich | 156361 | Hydantoin 98% | 461-72-3 | 500g | $134 | 2026-04-30 | Buy |
| Sigma-Aldrich | 8.04511 | Hydantoin for synthesis | 461-72-3 | 100g | $40.6 | 2025-07-31 | Buy |
| TCI Chemical | H0167 | Hydantoin >99.0%(T) | 461-72-3 | 25g | $31 | 2026-04-30 | Buy |
Hydantoin Chemical Properties,Uses,Production
Description
Hydantoin is a fundamental structural unit of organic compounds, serving as a building block for the preparation of hydantoin drugs. Hydantoin drugs are a class of anticonvulsants. Compounds such as phenytoin or fosphenytoin incorporate the hydantoin structure and are employed in the treatment of epilepsy.
Chemical Properties
White Solid
Uses
The product has been used as a substrate (at 40 °C and pH 9.0) to determine the D-hydantoinase activity in adzuki bean extract.
Uses
Reactant for synthesis of: N-benzyl aplysinopsin analogs as anticancer agents, D-glutamic acid based inhibitors, Antidiabetic chromonyl-2,4-thiazolidinediones, GSK-3β, inhibitors with brain permeability, Thiazolidinedione derivatives as 15-PGDH inhibitors, and Radio-sensitizing agents.
Definition
ChEBI: Hydantoin is an imidazolidine-2,4-dione.
Pharmaceutical Applications
Control of generalized convulsive status epilepticus; prevention and treatment of seizures during neurosurgery; short-term substitute for oral phenytoin.
Mechanism of action
Hydantoins are a class of drugs mainly used to treat seizures (anticonvulsant or antiepileptic drugs). Hydantoins reduce seizures by targeting the sodium channel present throughout the nerves. Activation of sodium channels results in the conduction of electrical impulses and the release of neurotransmitters. It could stabilise neuronal membranes by decreasing sodium and calcium ion influx into the neurons. Also decreases post-tetanic potentiation and repetitive discharge.
Pharmacokinetics
Completely absorbed after IM administration. Protein binding: 95%–99%. Rapidly and completely hydrolyzed to phenytoin after IM or IV administration. Time of complete conversion to phenytoin: 4 hr after IM injection; 2 hr after IV infusion. Half-life: 8–15 min (for conversion to phenytoin).
Hydantoin Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Shijiazhuang Donghua Jinlong Chemical Co., LTD | +86-031166619888 +86-19333738986 | donghuajinlong@glycine.com.cn | China | 30 | 58 |
| Shanghai Hehua Chemical Co.，Ltd | +86-15800509834 +86-15800509834 | sales@hehuachemical.com | China | 121 | 58 |
| Hebei Yanxi Chemical Co., Ltd. | +8618531123677 | faithe@yan-xi.com | China | 5853 | 58 |
| Hebei Chuanghai Biotechnology Co., Ltd | +8615531151365 | mina@chuanghaibio.com | China | 18126 | 58 |
| Hebei Zhuanglai Chemical Trading Co.,Ltd | +8613343047651 | admin@zlchemi.com | China | 3692 | 58 |
| HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | +86-15350851019; +8615350851019 | admin@86-ss.com | China | 999 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21585 | 55 |
| career henan chemical co | +86-0371-86658258 +8613203830695 | sales@coreychem.com | China | 29812 | 58 |
| Shandong chuangyingchemical Co., Ltd. | 18853181302 | sale@chuangyingchem.com | CHINA | 5906 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49979 | 58 |
Related articles
- Recent applications of hydantoin in medicinal chemistry
- Hydantoin, imidazolidine-2,4-dione, is a non-aromatic five-membered heterocycle, which is considered a valuable, privileged sc....
- Feb 28，2025
View Lastest Price from Hydantoin manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2026-07-10 | Hydantoin
461-72-3
|
$75.00-100.00 | 1kg | 99% | 5000 | HEBEI SHENGSUAN CHEMICAL INDUSTRY CO.,LTD | |
 |
2026-07-10 | Hydantoin
461-72-3
|
1KG | 98%min | 30tons/month | WUHAN FORTUNA CHEMICAL CO., LTD | ||
 |
2025-12-24 | Hydantoin
461-72-3
|
1KG | 99.0% | 1000 tons | Shaanxi Dideu Medichem Co. Ltd |
