Sodium tolmetin dihydrate
- CAS No.
- 64490-92-2
- Chemical Name:
- Sodium tolmetin dihydrate
- Synonyms
- Tolmene;McN 2559-21-98;TOLMELINSODIUM;tolmetinsodiumdihydrate;sodiumtolmetindihydrate;Tolmetin Sodium (500 mg);Tolmetin Sodium (1670502);Tormetine Sodium (Dihydrate);TolMetin sodiuM salt dehydrate;TOLMETIN SODIUM SALT DIHYDRATE
- CBNumber:
- CB2352833
- Molecular Formula:
- C15H14NO3.Na.2H2O
- Molecular Weight:
- 315.3
- MDL Number:
- MFCD00150761
- MOL File:
- 64490-92-2.mol
- MSDS File:
- SDS
| Melting point | 155-157 (dec.) |
|---|---|
| storage temp. | -20°C Freezer |
| solubility | Methanol (Slightly), Water (Slightly) |
| form | Solid |
| color | White to Beige |
| Water Solubility | Soluble in water |
| InChIKey | QQILXENAYPUNEA-UHFFFAOYSA-M |
| CAS DataBase Reference | 64490-92-2(CAS DataBase Reference) |
| FDA UNII | 02N1TZF99F |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS07,GHS08 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H302-H361d | |||||||||
| Precautionary statements | P202-P264-P270-P280-P301+P312-P308+P313 | |||||||||
| Hazard Codes | Xn | |||||||||
| Risk Statements | 22-38 | |||||||||
| Safety Statements | 36 | |||||||||
| WGK Germany | 3 | |||||||||
| RTECS | UX9280000 | |||||||||
| HS Code | 2933995500 | |||||||||
| NFPA 704 |
|
Sodium tolmetin dihydrate price More Price(22)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1670502 | Tolmetin sodium United States Pharmacopeia (USP) Reference Standard | 64490-92-2 | 500mg | $174.4 | 2024-03-01 | Buy |
| Alfa Aesar | J62663 | Tolmetin sodium salt dihydrate 98+% | 64490-92-2 | 1g | $43.65 | 2024-03-01 | Buy |
| Alfa Aesar | J62663 | Tolmetin sodium salt dihydrate 98+% | 64490-92-2 | 5g | $148.65 | 2024-03-01 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 1g | $32 | 2024-03-01 | Buy |
| Cayman Chemical | 18195 | Tolmetin (sodium salt hydrate) ≥98% | 64490-92-2 | 5g | $116 | 2024-03-01 | Buy |
Sodium tolmetin dihydrate Chemical Properties,Uses,Production
Chemical Properties
Crystalline Solid
Uses
Anti-inflammatory.
Uses
beta-adrenergic blocker
Definition
ChEBI: An organic sodium salt that is the dihydrate form of tolmetin sodium. Used as a nonselective nonsteroidal anti-inflammatory drug.
Biological Activity
tolmetin is a non-steroidal anti-inflammatory drug that non-selectively inhibits human cox-1 and -2 [1].the cyclooxygenase (cox) is a therapeutic target for preventing cancer. two isoforms of cox have been identified: cox 1 and cox 2. cox 1 has been constitutively expressed in most tissues and involved in mediating production of prostaglandins that control normal physiological functions, such as maintenance of the gastric mucosa and regulation of renal blood flow. cox 2 is undetectable in most normal tissues [2].
in vitro
tolmetin inhibited the activity of human cox-1 and -2 with ic50 values of 0.35 and 0.82 μm, respectively [1]. tolmetin was a competitive and reversible inhibitor of prostaglandin synthetase [3].
in vivo
in rats, pretreatment with tolmetin reduced prostaglandin synthesis by minces of renal medulla. incubation of medullary tissue with tolmetin decreased prostagland production. in anesthetized dogs, tolmetin reduced renal blood flow and shifted the distribution of renal cortical flow from the inner cortex toward the outer cortex [4].
References
[1] warner t d, giuliano f, vojnovic i, et al. nonsteroid drug selectivities for cyclo-oxygenase-1 rather than cyclo-oxygenase-2 are associated with human gastrointestinal toxicity: a full in vitro analysis[j]. proceedings of the national academy of sciences, 1999, 96(13): 7563-7568.
[2] dannenberg a j, altorki n k, boyle j o, et al. cyclo-oxygenase 2: a pharmacological target for the prevention of cancer[j]. the lancet oncology, 2001, 2(9): 544-551.
[3] taylor r j, salata j j. inhibition of prostaglandin synthetase by tolmetin (tolectin, mcn-2559), a new non-steroidal anti-inflammatory agent[j]. biochemical pharmacology, 1976, 25(22): 2479-2484.
[4] noordewier b, stygles v g, hook j b, et al. effect of tolmetin on renal function and prostaglandin metabolism[j]. journal of pharmacology and experimental therapeutics, 1978, 204(2): 461-468.
Sodium tolmetin dihydrate Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Mojin Biotechnology Co., Ltd | +8613288715578 | sales@hbmojin.com | China | 12456 | 58 |
| Ouhuang Engineering Materials (Hubei) Co., Ltd | +8617702722807 | admin@hbouhuang.com | China | 2259 | 58 |
| Capot Chemical Co.,Ltd. | 571-85586718 +8613336195806 | sales@capotchem.com | China | 29797 | 60 |
| Taizhou Tianhong Biochemistry Technology Co., Ltd. | 0523-86132544 | sales@thbiochem.com | CHINA | 305 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hebei Guanlang Biotechnology Co., Ltd. | +86-19930503282 | alice@crovellbio.com | China | 8823 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63711 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49390 | 58 |
| Hubei Ipure Biology Co., Ltd | +8613367258412 | ada@ipurechemical.com | China | 10326 | 58 |
View Lastest Price from Sodium tolmetin dihydrate manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Sodium tolmetin dihydrate
64490-92-2
|
US $50.00 / kg | 1kg | 99.10% | 50000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2023-07-26 | Sodium tolmetin dihydrate
64490-92-2
|
US $500.00 / g | 100g | 99% | 200ton | Hebei Mojin Biotechnology Co., Ltd | |
 |
2023-05-25 | Sodium tolmetin dihydrate
64490-92-2
|
US $10.00 / KG | 1KG | 99% | 10 mt | Hebei Guanlang Biotechnology Co., Ltd. |
-
- Sodium tolmetin dihydrate
64490-92-2
- US $50.00 / kg
- 99.10%
- Ouhuang Engineering Materials (Hubei) Co., Ltd
-
- Sodium tolmetin dihydrate
64490-92-2
- US $500.00 / g
- 99%
- Hebei Mojin Biotechnology Co., Ltd
-
- Sodium tolmetin dihydrate
64490-92-2
- US $10.00 / KG
- 99%
- Hebei Guanlang Biotechnology Co., Ltd.