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Vinflunine

Vinflunine structure

CAS No.: 162652-95-1

Chemical Name:: Vinflunine

Synonyms: VINFLUNINE;vinflunine（97%）;Vinflunine Tartrate;Vinflunine (F12158);Vinflunine USP/EP/BP;Vinflunine 162652-95-1;20',20'-Difluoro-3',4'-dihydrovinorelbine;4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine;4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine;Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1

CBNumber:: CB2358406

Molecular Formula:: C45H54F2N4O8

Molecular Weight:: 816.94

MDL Number:: MFCD00938122

MOL File:: 162652-95-1.mol

Last updated:2022-12-21 16:56:50

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Vinflunine Properties

Density	1.39±0.1 g/cm3(Predicted)
pka	11.36±0.60(Predicted)
CAS DataBase Reference	162652-95-1(CAS DataBase Reference)
FDA UNII	5BF646324K
NCI Dictionary of Cancer Terms	vinflunine
NCI Drug Dictionary	vinflunine
ATC code	L01CA05

Pharmacokinetic data

Protein binding	66.1-68.3%
Excreted unchanged in urine	33%
Volume of distribution	35(L/kg)
Biological half-life	40 / Increased

Vinflunine price

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
American Custom Chemicals Corporation	API0004596	VINFLUNINE 95.00%	162652-95-1	5MG	$501.95	2021-12-16	Buy
Crysdot	CD31003132	Vinflunine 98+%	162652-95-1	100mg	$966	2021-12-16	Buy
AvaChem	2180	Vinflunine	162652-95-1	100mg	$1680	2021-12-16	Buy
Crysdot	CD31003132	Vinflunine 98+%	162652-95-1	5mg	$88	2021-12-16	Buy
AvaChem	2180	Vinflunine	162652-95-1	5mg	$135	2021-12-16	Buy

Product number	Packaging	Price	Buy
API0004596	5MG	$501.95	Buy
CD31003132	100mg	$966	Buy
2180	100mg	$1680	Buy
CD31003132	5mg	$88	Buy
2180	5mg	$135	Buy

Vinflunine Chemical Properties,Uses,Production

Description

Vinflunine (also referred to as PM391) is a semisynthetic analog of the natural vinca alkaloids vinblastine and vincristine that was approved by the European Medicines Agency (EMEA) in 2009 for the treatment of adult patients with advanced or metastatic transitional cell carcinoma of the urothelial tract after failure of a prior platinum-containing regimen. Vinflunine is synthesized from anhydrovinblastine in a superacid media (HF-SbF₅) and in the presence of a chlorinated solvent like CHCl₃ or CCl₄.

Originator

Pierre Fabre (France)

Definition

ChEBI: An organic heteropentacyclic compound and an organic heterotetracyclic compound that is vinorelbine in which the tetrahydropyridine moiety of the heterotetracyclic part of the molecule has been redced to the corresponding piperidine, and in which the ethy group attached to this ring has been replaced by a 1,1-difluoroethyl group.

brand name

Javlor

Clinical Use

Antineoplastic agent (vinca alkaloid):
Treatment of advanced or metastatic bladder cancer

Drug interactions

Potentially hazardous interactions with other drugs
Antibacterials: possible increased risk of ventricular arrhythmias with delamanid; concentration possibly reduced by rifampicin - avoid.
Antidepressants: concentration possibly reduced by St Johns wort - avoid.
Antifungals: concentration increased by ketoconazole and possibly itraconazole (increased risk of neurotoxicity) - avoid.
Antimalarials: avoid with piperaquine with artenimol.
Antipsychotics: avoid with clozapine (increased risk of agranulocytosis).
Antivirals: concentration possibly increased by ritonavir - avoid.
Grapefruit juice: concentration of vinflunine increased - avoid.

Metabolism

Metabolised by the cytochrome CYP3A4 isoenzyme, except for 4-O-deacetylvinflunine (DVFL), the only active metabolite and main metabolite in blood which is formed by multiple esterases. Excretion occurs via the faeces (about two-thirds) and the urine (about one-third).

Vinflunine synthesis

Synthesis of Vinflunine from Vinorelbine

Vinflunine Preparation Products And Raw materials

Raw materials

Vinorelbine

Preparation Products

Vinflunine Suppliers

Global( 99)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Henan Tianfu Chemical Co.,Ltd.	+86-0371-55170693 +86-19937530512	info@tianfuchem.com	China	21695	55
Shanghai Zheyan Biotech Co., Ltd.	18017610038	zheyansh@163.com	CHINA	3620	58
career henan chemical co	+86-0371-86658258	sales@coreychem.com	China	29914	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	+8613815430202	sale02@cqherb.com	CHINA	376	58
Chongqing Chemdad Co., Ltd	+86-023-61398051 +8613650506873	sales@chemdad.com	China	39916	58
SIMAGCHEM CORP	+86-13806087780	sale@simagchem.com	China	17367	58
ANHUI WITOP BIOTECH CO., LTD	+8615255079626	eric@witopchemical.com	China	23556	58
Dideu Industries Group Limited	+86-29-89586680 +86-15129568250	1026@dideu.com	China	29321	58
AFINE CHEMICALS LIMITED	0571-85134551	info@afinechem.com	CHINA	15377	58

Supplier	Advantage
Henan Tianfu Chemical Co.,Ltd.	55
Shanghai Zheyan Biotech Co., Ltd.	58
career henan chemical co	58
Hubei Jusheng Technology Co.,Ltd.	58
NanJing Spring & Autumn Biological Engineering CO., LTD.	58
Chongqing Chemdad Co., Ltd	58
SIMAGCHEM CORP	58
ANHUI WITOP BIOTECH CO., LTD	58
Dideu Industries Group Limited	58
AFINE CHEMICALS LIMITED	58

View Lastest Price from Vinflunine manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2022-02-14	Vinflunine 162652-95-1 162652-95-1	US $30.00 / mg	20mg	≥98%	1000.00 kgs	NanJing Spring & Autumn Biological Engineering CO., LTD.
	2019-08-06	Vinflunine 162652-95-1	US $1.00 / KG	1KG	95%-99%	2000kg	Career Henan Chemical Co

Vinflunine 162652-95-1
162652-95-1
US $30.00 / mg
≥98%
NanJing Spring & Autumn Biological Engineering CO., LTD.

Vinflunine
162652-95-1
US $1.00 / KG
95%-99%
Career Henan Chemical Co

162652-95-1(Vinflunine)Related Search:

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Vinflunine INDOLE-2-ACETIC ACID 3,3,5,5-TETRAMETHYLCYCLOHEXANOL 1-HYDROXY-CYCLOHEXANECARBOXYLIC ACID L-LEUCIC ACID

(2-METHOXY-5-METHYLPHENYL)ACETIC ACID 3-PHENETHYL-PIPERIDINE (2S,3R)-3-AMINO-2-HYDROXY-4-PHENYLBUTYRIC ACID HYDROCHLORIDE

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VINFLUNINE 20',20'-Difluoro-3',4'-dihydrovinorelbine 4'-Deoxy-20',20'-difluoro-5'-norvincaleukoblastine 4'-Deoxy-20',20'-difluoro-8'-norvincaleukoblastine Vinflunine Tartrate Vinflunine 162652-95-1 Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- Vinflunine USP/EP/BP Vinflunine (F12158) Aspidospermidine-3-carboxylicacid,4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-1 vinflunine（97%） Aspidospermidine-3-carboxylic acid, 4-(acetyloxy)-6,7-didehydro-15-[(2R,4R,6S,8S)-4-(1,1-difluoroethyl)-1,3,4,5,6,7,8,9-octahydro-8-(methoxycarbonyl)-2,6-methano-2H-azecino[4,3-b]indol-8-yl]-3-hydroxy-16-methoxy-1-methyl-, methyl ester, (2β,3β,4β,5α,12R,19α)- 162652-95-1 C45H54F2N4O8 Miscellaneous Natural Products