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Desogestrel

Desogestrel
Desogestrel structure
CAS No.
54024-22-5
Chemical Name:
Desogestrel
Synonyms
org2969;Cyclosa;Desogen;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL;Desogestrelum;Desogestrel>
CBNumber:
CB2359630
Molecular Formula:
C22H30O
Formula Weight:
310.47
MOL File:
54024-22-5.mol

Desogestrel Properties

Melting point:
109-110°C
alpha 
D20 +55° (chloroform)
Boiling point:
390.62°C (rough estimate)
Density 
1.0169 (rough estimate)
refractive index 
1.5100 (estimate)
storage temp. 
-20°C Freezer
solubility 
Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride.
form 
neat
pka
13.07±0.40(Predicted)
Merck 
14,2926
FDA UNII
81K9V7M3A3
NCI Drug Dictionary
Cerazette
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS09
Signal word  Warning
Hazard statements  H410
Precautionary statements  P273-P501
Safety Statements  24/25
RIDADR  UN 3077 9 / PGIII
WGK Germany  3
RTECS  JF7975000
HS Code  29372390

Desogestrel price More Price(11)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 32809 Desogestrel VETRANAL 54024-22-5 25mg $155 2021-03-22 Buy
Sigma-Aldrich Y0000509 Desogestrel European Pharmacopoeia (EP) Reference Standard 54024-22-5 $190 2021-03-22 Buy
Sigma-Aldrich 1173235 Desogestrel United States Pharmacopeia (USP) Reference Standard 54024-22-5 100 mg $360 2021-03-22 Buy
Sigma-Aldrich 1173235 Desogestrel United States Pharmacopeia (USP) Reference Standard 54024-22-5 50mg $366 2021-03-22 Buy
TCI Chemical D4163 Desogestrel >98.0%(HPLC) 54024-22-5 100mg $137 2021-03-22 Buy

Desogestrel Chemical Properties,Uses,Production

Chemical Properties

White Solid

Originator

Dicromil,Organol ,W. Germany,1981

Uses

A progestogen with low androgenic potency

Manufacturing Process

A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33 ml tetrahydrofuran was added to a potassium-acetylide solution in tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with 2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane 0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.

Therapeutic Function

Progestin

General Description

Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.

Clinical Use

Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.

Desogestrel Preparation Products And Raw materials

Raw materials

Preparation Products


Desogestrel Suppliers

Global( 214)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22607 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 29961 58
TianYuan Pharmaceutical CO.,LTD
+86-755-23284190 13684996853
+86-755-23284190 sales@tianpharm.com CHINA 305 58
Cangzhou Wanyou New Material Technology Co.,Ltd
18631714998
sales@czwytech.com CHINA 914 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6369 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23035 58
Chongqing Chemdad Co., Ltd
+86-13650506873
sales@chemdad.com CHINA 37282 58
Hebei shuoxi biotechnology co. LTD
+8613081092107
whatsapp:+8613081092107 julia@hbshuoxi.com CHINA 973 58
Neostar United (Changzhou) Industrial Co., Ltd.
+0086-519-85557386
+0086-519-85557389 marketing1@neostarunited.com CHINA 4135 58
Nanjing Shizhou Biotechnology Co., Ltd
(+86)18013869214
(+86)25-85563444 sean.lv@synzest.com CHINA 2360 58

View Lastest Price from Desogestrel manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-20 Desogestrel
54024-22-5
US $5.00 / KG 1KG 99% 20 Tons Wuhan wingroup Pharmaceutical Co., Ltd
2021-09-29 Desogestrel
54024-22-5
US $0.00 / g/Bag 10g 99%min; EP7.0 25kg/month WUHAN FORTUNA CHEMICAL CO., LTD
2021-09-29 Desogestrel
54024-22-5
US $0.00-0.00 / KG 1g 99%min;EP 5kg WUHAN FORTUNA CHEMICAL CO., LTD

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