Desogestrel
- CAS No.
- 54024-22-5
- Chemical Name:
- Desogestrel
- Synonyms
- Desogestrel for system suitability CRS;Desogen;Desogestrel CRS;org2969;Cyclosa;Dicromil;DESTODENE;Cerazette;DESOGESTREL;DESOGESTRAL
- CBNumber:
- CB2359630
- Molecular Formula:
- C22H30O
- Molecular Weight:
- 310.47
- MDL Number:
- MFCD00869346
- MOL File:
- 54024-22-5.mol
- MSDS File:
- SDS
| Melting point | 109-110°C |
|---|---|
| alpha | D20 +55° (chloroform) |
| Boiling point | 390.62°C (rough estimate) |
| Density | 1.0169 (rough estimate) |
| refractive index | 1.5100 (estimate) |
| storage temp. | -20°C Freezer |
| solubility | Practically insoluble in water, very soluble in methanol, freely soluble in anhydrous ethanol and in methylene chloride. |
| pka | 13.07±0.40(Predicted) |
| color | White to Almost white |
| Merck | 14,2926 |
| FDA UNII | 81K9V7M3A3 |
| NCI Drug Dictionary | Cerazette |
| ATC code | G03AC09 |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |   GHS08,GHS09 |
|---|---|
| Signal word | Danger |
| Hazard statements | H360FD-H410 |
| Precautionary statements | P202-P273-P280-P308+P313-P391-P405 |
| Safety Statements | 24/25 |
| RIDADR | UN 3077 9 / PGIII |
| WGK Germany | 3 |
| RTECS | JF7975000 |
| HS Code | 29372390 |
Desogestrel price More Price(30)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 1173235 | Desogestrel United States Pharmacopeia (USP) Reference Standard | 54024-22-5 | 100mg | $436 | 2024-03-01 | Buy |
| Sigma-Aldrich | 32809 | Desogestrel VETRANAL | 54024-22-5 | 25mg | $164 | 2022-05-15 | Buy |
| Sigma-Aldrich | 1173235 | Desogestrel United States Pharmacopeia (USP) Reference Standard | 54024-22-5 | 50mg | $452 | 2022-05-15 | Buy |
| TCI Chemical | D4163 | Desogestrel >98.0%(HPLC) | 54024-22-5 | 100mg | $159 | 2024-03-01 | Buy |
| Cayman Chemical | 23651 | Desogestrel ≥95% | 54024-22-5 | 5mg | $61 | 2024-03-01 | Buy |
Desogestrel Chemical Properties,Uses,Production
Description
Desogestrel is a synthetic progestogen. It inhibits ovulation and prevents fertilization in rabbits and mice. Desogestrel inhibits rhodamine 123 efflux, a measure of P-glycoprotein activity, ex vivo in human lymphocytes and CD8+ T cells in a dose-dependent manner. Formulations containing desogestrel have been used as oral contraceptives and for the treatment of polycystic ovary syndrome.
Chemical Properties
White Solid
Originator
Dicromil,Organol ,W. Germany,1981
Uses
A progestogen with low androgenic potency
Definition
ChEBI: Desogestrel is a 17beta-hydroxy steroid and a terminal acetylenic compound. It has a role as a contraceptive drug, a progestin and a synthetic oral contraceptive.
Manufacturing Process
A solution of 1.0 g of 11,11-methylene-18-methyl-delta4-estren-17-one in 33
ml tetrahydrofuran was added to a potassium-acetylide solution in
tetrahydrofuran.
After 2 hours of stirring at 0°C to 5°C the reaction mixture was acidified with
2N H2SO4and processed further.
By a chromatographic treatment on silica gel and crystallization from pentane
0.7 g of 11,11-methylene-17α-ethynyl-18-methyl-δ4-estren-17β-ol with a
melting point of 109°C to 110°C and an [α]D of +55°C (CHCl3) was obtained.
Therapeutic Function
Progestin
General Description
Desogestrel, (17α)-13-ethyl-11-methylene-18,19-dinorpregn-4-en-20-yn-17-ol, is a 19-nortestosterone analog with good progestin activity. Likethe other progestins, it is orally active and used in combinationwith an estrogen in oral contraceptives. Desogestrel is aprodrug that must be oxidized to the 3-one in vivo to haveprogestational action. CYPs 2C9 and 2C19 have been implicatedin the initial hydroxylation of desogestrel at C3.
Clinical Use
Desogestrel also is a prodrug and is rapidly metabolized in the intestinal mucosa and on first pass through the liver to its active metabolite, etonogestrel (3-ketodesogestrel). Following oral administration, the relative bioavailability for desogestrel is approximately 84%. Desogestrel also exhibits high selectivity for the progesterone receptor and low and rogenic activity, and it does not diminish the beneficial effects of estrogen on the lipid profile.
Desogestrel Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Nantong Guangyuan Chemicl Co,Ltd | +undefined17712220823 | admin@guyunchem.com | China | 616 | 58 |
| Henan Tianfu Chemical Co.,Ltd. | +86-0371-55170693 +86-19937530512 | info@tianfuchem.com | China | 21695 | 55 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| TianYuan Pharmaceutical CO.,LTD | +86-755-23284190 13684996853 | sales@tianpharm.com | CHINA | 304 | 58 |
| Cangzhou Wanyou New Material Technology Co.,Ltd | 18631714998 | sales@czwytech.com | CHINA | 906 | 58 |
| Xiamen AmoyChem Co., Ltd | +86-592-6051114 +8618959220845 | sales@amoychem.com | China | 6387 | 58 |
| Hubei xin bonus chemical co. LTD | 86-13657291602 | linda@hubeijusheng.com | CHINA | 22968 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| Hebei shuoxi biotechnology co. LTD | +8613081092107 | CHINA | 968 | 58 | |
| Neostar United (Changzhou) Industrial Co., Ltd. | +86-519-519-85557386 | marketing1@neostarunited.com | China | 8349 | 58 |
View Lastest Price from Desogestrel manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-22 | Desogestrel
54024-22-5
|
US $0.00-0.00 / kg | 1kg | 98% | 20tons | Sinoway Industrial co., ltd. | |
 |
2024-04-17 | Desogestrel
54024-22-5
|
US $1.10 / g | 1g | 99.0% min | 100 tons min | Shaanxi Dideu Medichem Co. Ltd | |
 |
2024-03-08 | Desogestrel
54024-22-5
|
US $10.00 / kg | 1kg | 99% | 1000kg | Nantong Guangyuan Chemicl Co,Ltd |
-
- Desogestrel
54024-22-5
- US $0.00-0.00 / kg
- 98%
- Sinoway Industrial co., ltd.
-
- Desogestrel
54024-22-5
- US $1.10 / g
- 99.0% min
- Shaanxi Dideu Medichem Co. Ltd
-
- Desogestrel
54024-22-5
- US $10.00 / kg
- 99%
- Nantong Guangyuan Chemicl Co,Ltd