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2-Phenylacetamide

CAS No.
103-81-1
Chemical Name:
2-Phenylacetamide
Synonyms
Benzeneacetamide;PHENYLACETAMIDE;Phenylacetic acid amide;-Toluamide;α-Toluamide;Phenacetamide;ALPHA-TOLUAMIDE;PHENYLETHANAMIDE;2-Pheylacetamide;2-phenyl-acetamid
CBNumber:
CB2360953
Molecular Formula:
C8H9NO
Molecular Weight:
135.16
MDL Number:
MFCD00059193
MOL File:
103-81-1.mol
MSDS File:
SDS
Last updated:2024-03-18 13:30:28

2-Phenylacetamide Properties

Melting point 156 °C
Boiling point 280-290 °C (dec.)
Density 1.1031 (rough estimate)
refractive index 1.5589 (estimate)
storage temp. Refrigerator
solubility Soluble in methanol.
pka 16.21±0.40(Predicted)
form Solid
color Plates or leaflets
Merck 14,7266
InChI InChI=1S/C8H9NO/c9-8(10)6-7-4-2-1-3-5-7/h1-5H,6H2,(H2,9,10)
InChIKey LSBDFXRDZJMBSC-UHFFFAOYSA-N
SMILES C1(CC(N)=O)=CC=CC=C1
CAS DataBase Reference 103-81-1(CAS DataBase Reference)
EWG's Food Scores 1
FDA UNII 5R219M9TJF
NIST Chemistry Reference Benzeneacetamide(103-81-1)
EPA Substance Registry System Benzeneacetamide (103-81-1)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H302-H319
Precautionary statements  P264-P280i-P301+P312a-P305+P351+P338-P337+P313-P501a
Hazard Codes  Xi
Risk Statements  22-36
Safety Statements  22-24/25-60-36-26
RTECS  AC7705000
TSCA  Yes
HazardClass  IRRITANT
HS Code  29242990
Toxicity LD50 ipr-mus: 430 mg/kg PCJOAU 10,579,76
NFPA 704
1
2 0

2-Phenylacetamide price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
TCI Chemical P0120 2-Phenylacetamide >98.0%(N) 103-81-1 25g $40 2024-03-01 Buy
TCI Chemical P0120 2-Phenylacetamide >98.0%(N) 103-81-1 500g $286 2024-03-01 Buy
Alfa Aesar H60626 2-Phenylacetamide, 99% 103-81-1 250mg $52.4 2024-03-01 Buy
TRC P335554 2-Phenylacetamide 103-81-1 100g $105 2021-12-16 Buy
Frontier Specialty Chemicals JK439749 2-Phenylacetamide 98% 103-81-1 100g $146 2021-12-16 Buy
Product number Packaging Price Buy
P0120 25g $40 Buy
P0120 500g $286 Buy
H60626 250mg $52.4 Buy
P335554 100g $105 Buy
JK439749 100g $146 Buy

2-Phenylacetamide Chemical Properties,Uses,Production

Chemical Properties

2-Phenylacetamide, also known as alpha-toluamide or benzeneacetamide, belongs to the class of organic compounds known as phenylacetamides. These are amide derivatives of phenylacetic acids. Pure crystals are plate shaped and colorless to white. soluble in hot water, ethanol, slightly soluble in cold water, ether and benzene.

Uses

In agriculture, 2-Phenylacetamid can be used in the production of many important intermediates of pesticides, such as carbamine. In the field of dyes: it can react with some monomers with color to produce some important raw materials for blue and purple dyes. In the field of fragrances, it can be used as an important raw material for the synthesis of certain spices and flavors. 2-Phenylacetamide can also be used in the synthesis of organometallic, organic peroxide, organic peroxide ester, and other compounds, and can be used as a crosslinking agent for polymers, a film forming agent for coatings, a plasticizer for plastics, etc.

Uses

2-Phenylacetamide is used as a pharmaceutical intermediate in the production of penicillin G and phenobarbital, etc. It is also used in organic synthesis.

Preparation

Synthesis of 2-phenylacetamide: Add concentrated hydrochloric acid to phenylacetonitrile, stir to dissolve, and react at 50°C for half an hour. Then slowly add water under cooling to separate out crystals, filter after cooling, wash with ice water to obtain crude product. The crude product was washed with sodium carbonate solution, then washed with ice water, and dried to obtain purer phenylacetamide.

Definition

ChEBI: 2-phenylacetamide is a monocarboxylic acid amide that is acetamide substituted by a phenyl group at position 2. It has a role as a mouse metabolite. It derives from a phenylacetic acid.

Synthesis Reference(s)

Journal of the American Chemical Society, 75, p. 740, 1953 DOI: 10.1021/ja01099a504
The Journal of Organic Chemistry, 43, p. 402, 1978 DOI: 10.1021/jo00397a005
Organic Syntheses, Coll. Vol. 4, p. 760, 1963

Biological Activity

2-Phenylacetamide, the main compound isolated from the seeds of Lepidium apetalum Willd (LA) with estrogenic activities, increases the expression of Estrogen receptorα (ERα), ERβ and GPR30 in the uterus and MCF-7 cells.

Safety Profile

Moderately toxic by intraperitoneal route. When heated to decomposition it emits toxic fumes of NOx.

Purification Methods

Crystallise the acetamide repeatedly from absolute EtOH, EtOAc (m 160-161o) or H2O (m 159-160o). Dry it in vacuo over P2O5. [Beilstein 9 H 347, 9 III 2193, 9 IV 1632.]

140-29-4
103-81-1
Synthesis of 2-Phenylacetamide from Benzeneacetonitrile
Global( 389)Suppliers
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Nanjing Deda New Material Technology Co., Ltd
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View Lastest Price from 2-Phenylacetamide manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
2-Phenylacetamide pictures 2024-03-19 2-Phenylacetamide
103-81-1
US $10.00-5.00 / kg 1kg 99.5 10 ton per month Nanjing Deda New Material Technology Co., Ltd
2-Phenylacetamide pictures 2024-03-19 2-Phenylacetamide
103-81-1
US $10.00-5.00 / kg 1kg 99.5 10 ton per month Nanjing Deda New Material Technology Co., Ltd
2-Phenylacetamide pictures 2024-03-19 2-Phenylacetamide
103-81-1
US $50.00-10.00 / kg 1kg 98% 300tons Hebei Dangtong Import and export Co LTD
  • 2-Phenylacetamide pictures
  • 2-Phenylacetamide
    103-81-1
  • US $10.00-5.00 / kg
  • 99.5
  • Nanjing Deda New Material Technology Co., Ltd
  • 2-Phenylacetamide pictures
  • 2-Phenylacetamide
    103-81-1
  • US $10.00-5.00 / kg
  • 99.5
  • Nanjing Deda New Material Technology Co., Ltd
  • 2-Phenylacetamide pictures
  • 2-Phenylacetamide
    103-81-1
  • US $50.00-10.00 / kg
  • 98%
  • Hebei Dangtong Import and export Co LTD
ALPHA-TOLUAMIDE ALPHA-PHENYLACETAMIDE 2-phenyl-acetamid Acetamide, 2-phenyl- alpha-toluimidicacid Phenacetamide phenylaceticacidamide Phenyl-beta-acetylamine -Toluamide 2-PHENYLACETAMIDE (ALPHA-) 98+% 2-alpha-Phenylacetamide PHENYLETHANAMIDE 2-PhenylacetaMide, 98.0%(N) a-Phenylacetamide Acetophenone aMide Phenyl ethyl aMide 2-phenylacetamide 103-81-1 2-PHENYLACETAMIDE 2-Pheylacetamide 2-Phenylacetamide phenobarbital Pharmaceutical Intermediates cas: 103-81-1 EDTA 2-phenylacetamide EDTA-2Na CAS NO. 103-81-1 Factory price 2-Phenylacetamide CAS NO.103-81-1 Hot sale 2-phenylacetamide 99.9% manufacturer CAS NO.103-81-1 2-phenylacetamide 99.9% CAS NO.103-81-1 Factory price 2-Phenylacetamide CAS:103-81-1 Hot sale 2-phenylacetamide 99.9% manufacturer Factory 2-phenylacetamide 99.9 purity for sale factory 99% 2-phenylacetamide for sale Top quality hot sale CAS: 103-81-1 2-Phenylacetamide manufacturer Pharmaceutical Intermediates for sale Manufacturer 2-Phenylacetamide 103-81-1 as 103-81-1 2-Phenylacetamide kf-wang(at)kf-chem.com 2-Phenylacetamide> Phenylacetamide Phenylacetamide α-phenylacetamide 2-Phenylacetamide Basic information 2-Phenylacetamide 103-81-1 CAS NO.103-81-1 2-Phenylacetamide ISO 9001:2015 REACH 2-Phenylacetamide / Phenylacetamide α-Toluamide 2-Phenylacetamide, 99%, PHENYLACETAMIDE Benzeneacetamide Phenylacetic acid amide 2-phenylacetamide manufacturer Benzeneacetamide (9CI, ACI) Benzylpenicillin Impurity 28 103-81-1 13-84-4 103-81-8 C6H5CH2CONH2 Pharmaceutical intermediates amine series 103-81-1