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Triptorelin

Antineoplastic drug
Triptorelin
Triptorelin structure
CAS No.
57773-63-4
Chemical Name:
Triptorelin
Synonyms
CL-118532;TRIPORELIN;Decapeptyl;Triptoreli;TRIPTORELIN;Tryptorelin;TRIPTORELINE;(D-TRP6)-LHRH;triptorelinum;Triptorelin/GnRH
CBNumber:
CB2366465
Molecular Formula:
C64H82N18O13
Formula Weight:
1311.47
MOL File:
57773-63-4.mol

Triptorelin Properties

alpha 
D23 -58.8° (c = 0.33 in acetic acid)
Density 
1.52±0.1 g/cm3(Predicted)
storage temp. 
-20°C
form 
powder
pka
9.82±0.15(Predicted)
InChIKey
HPPONSCISKROOD-OYLNGHKZSA-N
CAS DataBase Reference
57773-63-4(CAS DataBase Reference)
EWG's Food Scores
1
FDA UNII
9081Y98W2V
NCI Dictionary of Cancer Terms
triptorelin
NCI Drug Dictionary
triptorelin
ATC code
L02AE04
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS08
Signal word  Danger
Hazard statements  H360
Precautionary statements  P201-P308+P313
Hazard Codes  T
Risk Statements  60
Safety Statements  53-22-36/37/39-45
WGK Germany  3
HS Code  2937190000

Triptorelin price More Price(25)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich L9761 [D-Trp6]-LH-RH ≥97% (HPLC), powder 57773-63-4 1mg $155 2021-12-16 Buy
Sigma-Aldrich L9761 [D-Trp6]-LH-RH ≥97% (HPLC), powder 57773-63-4 5mg $364 2021-12-16 Buy
Cayman Chemical 28613 Triptorelin 57773-63-4 5mg $89 2021-12-16 Buy
Cayman Chemical 28613 Triptorelin 57773-63-4 25mg $334 2021-12-16 Buy
TRC T815803 Triptorelin 57773-63-4 50mg $1240 2021-12-16 Buy

Triptorelin Chemical Properties,Uses,Production

Antineoplastic drug

The active ingredient of triptorelin is a synthetic gonadotropin-releasing hormone (GnRH) analogue, which is also known as decapeptyl, diphereline, triptorelin acetate, gonadorelin. It is an antineoplastic drug, whose pharmacological effects are same with goserelin, buserelin, and its structure is modified by natural molecular structure of the sixth L-glycine that is replaced by D-tryptophan to promote efficiency and prolong the plasmic half-life time, as well as enhance drug efficacy. After intramuscular injection, it initially stimulates the pituitary gland to release luteinizing growth hormone (LH) and follicle-stimulating hormone (FSH). When the pituitary over a long period of stimulation will be into the refractory period, that reduced the release of gonadotropin, leading to sex hormones reduction to castrate levels. These effects are reversible. Subcutaneous administration is rapidly absorbed, and Tmax is 15min, and the effect is maximum at 1h. The intramuscular injection of sustained release formulations can maintain the efficacy reaching 28d or more. It Clinically uses for the treatment of endometriosis, hormone-dependent prostate cancer, breast cancer, precocious puberty, as well as it may also be used as assisted reproductive technology. The main side effects of triptorelin are as follows: In the early stage of treatment of male, it can cause urinary disorders, breast swelling and pain, bone pain, and it may also cause hot flashes, loss of libido and impotence. It rarely cause gynecomastia, testicular atrophy, and sleep disorders. In the first week of treatment for children, girls will occur small amount of vaginal bleeding, which can be corrected by short-term additional therapy. During the treatment of women, hot flashes, bleeding or bleeding spots, vaginal dryness, headaches and weakness can occur. It can cause abdominal and (or) pelvic pain when it uses combination with gonadotropin. Since the concentration of estrogen reduces to the level of post-menopause, it can cause slight loss of trabecular bone matrix. Generally, after cessation of treatment six to nine months the adverse reations can return to normal. There may be irreversible amenorrhea after treatment in patients with endometriosis.
The above information is edited by the chemicalbook of Kui Ming.

Description

Decapeptyl is a modified (D-Trp6) LH-RH. Like recently marketed buserelin and leuprolide (I), it is useful in achieving medical castration in the treatment of advanced prostate cancer.

Originator

Tulane Univ. (USA)

Uses

promoting ovulation

Uses

Triptorelin is a GnRH agaonist shown to inhibit estradiol-induced cancer cell proliferation.

Definition

ChEBI: An oligopeptide comprising pyroglutamyl, histidyl, tryptophyl, seryl, tyrosyl, D-tryptophyl, leucyl, arginyl, prolyl and glycinamide residues joined in sequence. It is an agonist analogue of gonadotropin-releasing hormone.

brand name

Trelstar (Watson).

Clinical Use

Triptorelin pamoate is another superagonist of GnRH, which like nafarelin acetate contains only a single amino acid substitution (D-Trp6 for Gly6) when compared to the natural hormone. In the treatment of advanced prostate cancer, it is important to reduce serum testosterone levels to very low levels, which can be achieved surgically by orchiectomy. When this surgical method is unacceptable to the patient, an alternative approach is “chemical castration,” which can be achieved by use of estrogen therapy, leuprolide,goserelin or histrelin acetates, and now, triptorelin pamoate. This product is available for IM depot injection (monthly or every 3 months), wherein serum testosterone concentration drops to a level generally seen in surgically castrated men.

Triptorelin Preparation Products And Raw materials

Raw materials

Preparation Products


Triptorelin Suppliers

Global( 250)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Cellmano Biotech Limited
18156095617 0551-65326643
0551-65326641 info@cellmano.com CHINA 1039 58
SUZHOU TIANMA PHARMA GROUP TIANJI BIO-PHARMACEUTICAL CO., LTD.
18315825527
kevin@tianmapharma.com CHINA 19 58
Alpha Biopharmaceuticals Co., Ltd
0086-411-39042497
0086-411-39042693 sales@alphabiopharm.com China 896 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com China 22607 55
Hangzhou FandaChem Co.,Ltd.
008615858145714
+86-571-56059825 fandachem@gmail.com China 9150 55
ATK CHEMICAL COMPANY LIMITED
+86 21 5161 9050/ 5187 7795
+86 21 5161 9052/ 5187 7796 ivan@atkchemical.com CHINA 26782 60
career henan chemical co
+86-0371-55982848
sales@coreychem.com China 29953 58
GZ HONCH CHEMICAL TECHNOLOGY CO.,LTD
+8613437848121
+8613437848121 chemicalbest@foxmail.com CHINA 226 58
Shaanxi Yikanglong Biotechnology Co., Ltd.
17791478691
yklbiotech@163.com CHINA 297 58
Chengdu Biopurify Phytochemicals Ltd.
18482058008 18080483897
maggie@biopurify.com China 2712 58

View Lastest Price from Triptorelin manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2022-01-26 Triptorelin/GnRH
57773-63-4
US $30.00-999.00 / g 1kit 99.99%HPLC.USP42——Powder、Oil、Pills、Capsules、Tablets,Customized packaging 10000kits/Month Wuhan Biocar Pharmacy Co., Ltd.
2022-01-25 Triptorelin
57773-63-4
US $1.00 / g 10g 99.5% 1000kg Guangzhou Biocar Biotechnology Co.,Ltd.
2022-01-25 Triptorelin
57773-63-4
US $30.00 / g 1000g 99% 20ton/month Wuhan Aoliqisi New Material Technology Co., Ltd.

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