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20ALPHA-HYDROXYCHOLESTEROL

20ALPHA-HYDROXYCHOLESTEROL
20ALPHA-HYDROXYCHOLESTEROL structure
CAS No.
516-72-3
Chemical Name:
20ALPHA-HYDROXYCHOLESTEROL
Synonyms
C05500;20-hydroxycholesterol;20A-HYDROXYCHOLESTEROL;20α-Hydroxy Cholesterol;Cholesterol Impurity 32;5-Cholestene-3B,20a-diol;5-cholestene-3β,20α-diol;Cholest-5-ene-3,20a-diol;Cholest-5-ene-3β,20-diol;20[S]-HYDROXYCHOLESTEROL
CBNumber:
CB2372501
Molecular Formula:
C27H46O2
Formula Weight:
402.65
MOL File:
516-72-3.mol
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20ALPHA-HYDROXYCHOLESTEROL Properties

Melting point
136-137°C
Boiling point
512.3±23.0 °C(Predicted)
Density
1.03±0.1 g/cm3(Predicted)
storage temp.
Inert atmosphere,2-8°C
form
neat
pka
15.04±0.70(Predicted)
FDA UNII
30060WAL99

SAFETY

Risk and Safety Statements

WGK Germany  3

20ALPHA-HYDROXYCHOLESTEROL price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H6378 20α-Hydroxycholesterol analytical standard 516-72-3 5mg $170 2022-05-15 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 1mg $44 2022-04-27 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 5mg $98 2022-04-27 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 10mg $173 2022-04-27 Buy
Tocris 4474 20(S)-Hydroxycholesterol ≥95%(HPLC) 516-72-3 10 $184 2021-12-16 Buy
Product number Packaging Price Buy
H6378 5mg $170 Buy
20103 1mg $44 Buy
20103 5mg $98 Buy
20103 10mg $173 Buy
4474 10 $184 Buy

20ALPHA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.

Chemical Properties

White Solid

Uses

A metabolite of Cholesterol (C432501). Cholesterol oxidation product having cytotoxicity effects.

Uses

A metabolite of Cholesterol (C432501). Cholesterol oxidation product having

Uses

A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects

Definition

ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.

20ALPHA-HYDROXYCHOLESTEROL synthesis

145-13-1
626-88-0
516-72-3
Synthesis of 20ALPHA-HYDROXYCHOLESTEROL from Pregnenolone and 1-Bromo-4-methylpentane

20ALPHA-HYDROXYCHOLESTEROL Preparation Products And Raw materials

Raw materials

4-METHYL-1-PENTYNE 1-Bromo-4-methylpentane 3-tert-Butyldimethylsilyloxy Pregnenolone Cholesterol Pregnenolone

Preparation Products

20ALPHA-HYDROXYCHOLESTEROL Suppliers

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
Creative Enzymes 		631-6197922 info@creative-enzymes.com United States 8748 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19231 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15877 69
Chemsky（shanghai）International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32358 50
BOC Sciences 16314854226 info@bocsci.com United States 21113 65
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9708 58
ChemStrong Scientific Co.,Ltd 0755-66853366 15920483169 sales@chem-strong.com China 18844 56
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8454 60
Aikon International Limited 025-58851090 13611564524 sales01@aikonchem.com China 16029 58
Supplier Advantage
Creative Enzymes 		58
TargetMol Chemicals Inc. 		58
J & K SCIENTIFIC LTD. 76
3B Pharmachem (Wuhan) International Co.,Ltd. 69
Chemsky（shanghai）International Co.,Ltd. 50
BOC Sciences 65
Clearsynth Labs Limited 58
ChemStrong Scientific Co.,Ltd 56
EMMX Biotechnology LLC 60
Aikon International Limited 58

516-72-3(20ALPHA-HYDROXYCHOLESTEROL)Related Search:

(S)-(+)-2-NONANOL 4-METHYL-4-PENTEN-2-OL 3-METHYL-4-OCTANOL 2-METHYL-5-NONANOL 2-METHYLEICOSANE
dodec-11-enol 2,3-DIMETHYL-2-HEXANOL 2-METHYLPENTADECANE 3-ETHYL-3-METHYL-1-PENTENE 4-CYCLOHEXYLCYCLOHEXANOL
5-ETHYL-3-NONANOL TRANS-9-DODECEN-1-OL octadecene 5-CHOLESTEN-3-BETA, 17-ALPHA, 20-ALPHA-TRIOL CIS-4-NONENE
20ALPHA-HYDROXYCHOLESTEROL 4-METHYL-5-OCTANOL 3-DECANOL
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20alpha-Hydroxycholesterol (not deuterated) 5-Cholestene-3B,20a-diol Cholest-5-ene-3,20-diol, (3.beta.)- 5-cholestene-3β,20α-diol (3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 20α-Hydroxycholesterol (not deuterated) (20S)-Cholest-5-ene-3,20-diol (3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) (3)-Cholest-5-ene-3,20-diol 20S-Cholest-5-ene-3,20-diol Cholest-5-ene-3,20a-diol (20S)-20-Hydroxycholesterol Cholest-5-ene-3β,20-diol C05500 20A-HYDROXYCHOLESTEROL 20ALPHA-HYDROXYCHOLESTEROL 20[S]-HYDROXYCHOLESTEROL 3BETA,20ALPHA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTENE-3B,20ALPHA-DIOL 5-CHOLESTENE-3BETA,20ALPHA-DIOL 5-CHOLESTEN-3-BETA, 20-ALPHA-DIOL 20-hydroxycholesterol Cholest-5-ene-3,20-diol, (3β)- 20α-Hydroxy Cholesterol Cholesterol Impurity 32 516-72-3 HU - HZ Alphabetic Analytical Standards Analytical Chromatography Product Catalog Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids Standards - 13C & 2H for GC-Mass Spectrometry