ChemicalBook >> CAS DataBase List >>20ALPHA-HYDROXYCHOLESTEROL

20ALPHA-HYDROXYCHOLESTEROL

CAS No.
516-72-3
Chemical Name:
20ALPHA-HYDROXYCHOLESTEROL
Synonyms
C05500;20-hydroxycholesterol;20A-HYDROXYCHOLESTEROL;20α-Hydroxy Cholesterol;Cholesterol Impurity 32;5-Cholestene-3B,20a-diol;5-cholestene-3β,20α-diol;Cholest-5-ene-3,20a-diol;Cholest-5-ene-3β,20-diol;20[S]-HYDROXYCHOLESTEROL
CBNumber:
CB2372501
Molecular Formula:
C27H46O2
Formula Weight:
402.65
MOL File:
516-72-3.mol

20ALPHA-HYDROXYCHOLESTEROL Properties

Melting point
136-137°C
Boiling point
512.3±23.0 °C(Predicted)
Density
1.03±0.1 g/cm3(Predicted)
storage temp.
Inert atmosphere,2-8°C
form
neat
pka
15.04±0.70(Predicted)
FDA UNII
30060WAL99

SAFETY

Risk and Safety Statements

WGK Germany  3

20ALPHA-HYDROXYCHOLESTEROL price More Price(19)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich H6378 20α-Hydroxycholesterol analytical standard 516-72-3 5mg $170 2022-05-15 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 1mg $44 2022-04-27 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 5mg $98 2022-04-27 Buy
Cayman Chemical 20103 20(S)-hydroxy Cholesterol ≥98% 516-72-3 10mg $173 2022-04-27 Buy
Tocris 4474 20(S)-Hydroxycholesterol ≥95%(HPLC) 516-72-3 10 $184 2021-12-16 Buy
Product number Packaging Price Buy
H6378 5mg $170 Buy
20103 1mg $44 Buy
20103 5mg $98 Buy
20103 10mg $173 Buy
4474 10 $184 Buy

20ALPHA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production

Description

20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells. 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo. 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.

Chemical Properties

White Solid

Uses

A metabolite of Cholesterol (C432501). Cholesterol oxidation product having cytotoxicity effects.

Uses

A metabolite of Cholesterol (C432501). Cholesterol oxidation product having

Uses

A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects

Definition

ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.

145-13-1
626-88-0
516-72-3
Synthesis of 20ALPHA-HYDROXYCHOLESTEROL from Pregnenolone and 1-Bromo-4-methylpentane

20ALPHA-HYDROXYCHOLESTEROL Preparation Products And Raw materials

20ALPHA-HYDROXYCHOLESTEROL Suppliers

Global( 48)Suppliers
Supplier Tel Email Country ProdList Advantage
Creative Enzymes
631-6197922 info@creative-enzymes.com United States 8748 58
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19231 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15877 69
Chemsky(shanghai)International Co.,Ltd. 021-50135380 shchemsky@sina.com China 32358 50
BOC Sciences 16314854226 info@bocsci.com United States 21113 65
Clearsynth Labs Limited +91-22-26355700 info@clearsynth.com India 9708 58
ChemStrong Scientific Co.,Ltd 0755-66853366 15920483169 sales@chem-strong.com China 18844 56
EMMX Biotechnology LLC 888-539-0666 info@emmx.com United States 8454 60
Aikon International Limited 025-58851090 13611564524 sales01@aikonchem.com China 16029 58
20alpha-Hydroxycholesterol (not deuterated) 5-Cholestene-3B,20a-diol Cholest-5-ene-3,20-diol, (3.beta.)- 5-cholestene-3β,20α-diol (3S,8S,9S,10R,13S,14S,17S)-17-[(2R)-2-hydroxy-6-methylheptan-2-yl]-10,13-dimethyl-2,3,4,7,8,9,11,12,14,15,16,17-dodecahydro-1H-cyclopenta[a]phenanthren-3-ol 20α-Hydroxycholesterol (not deuterated) (20S)-Cholest-5-ene-3,20-diol (3S,8S,9S,10R,13S,14S,17S)-17-((S)-2-hydroxy-6-methylheptan-2-yl)-10,13-dimethyl-2,3,4,7,8,9,10,11,12,13,14,15,16,17-tetradecahydro-1H-cyclopenta[a]phenanthren-3-ol 20(S)-hydroxyCholesterol (20α-Hydroxycholesterol) (3)-Cholest-5-ene-3,20-diol 20S-Cholest-5-ene-3,20-diol Cholest-5-ene-3,20a-diol (20S)-20-Hydroxycholesterol Cholest-5-ene-3β,20-diol C05500 20A-HYDROXYCHOLESTEROL 20ALPHA-HYDROXYCHOLESTEROL 20[S]-HYDROXYCHOLESTEROL 3BETA,20ALPHA-DIHYDROXY-5-CHOLESTENE 5-CHOLESTENE-3B,20ALPHA-DIOL 5-CHOLESTENE-3BETA,20ALPHA-DIOL 5-CHOLESTEN-3-BETA, 20-ALPHA-DIOL 20-hydroxycholesterol Cholest-5-ene-3,20-diol, (3β)- 20α-Hydroxy Cholesterol Cholesterol Impurity 32 516-72-3 HU - HZ Alphabetic Analytical Standards Analytical Chromatography Product Catalog Intermediates & Fine Chemicals Metabolites & Impurities Pharmaceuticals Steroids Standards - 13C & 2H for GC-Mass Spectrometry