20ALPHA-HYDROXYCHOLESTEROL
- CAS No.
- 516-72-3
- Chemical Name:
- 20ALPHA-HYDROXYCHOLESTEROL
- Synonyms
- C05500;20-hydroxycholesterol;20A-HYDROXYCHOLESTEROL;20α-Hydroxy Cholesterol;Cholesterol Impurity 32;5-Cholestene-3B,20a-diol;5-cholestene-3β,20α-diol;Cholest-5-ene-3,20a-diol;Cholest-5-ene-3β,20-diol;20[S]-HYDROXYCHOLESTEROL
- CBNumber:
- CB2372501
- Molecular Formula:
- C27H46O2
- Formula Weight:
- 402.65
- MOL File:
- 516-72-3.mol
- Melting point
- 136-137°C
- Boiling point
- 512.3±23.0 °C(Predicted)
- Density
- 1.03±0.1 g/cm3(Predicted)
- storage temp.
- Inert atmosphere,2-8°C
- form
- neat
- pka
- 15.04±0.70(Predicted)
- FDA UNII
- 30060WAL99
20ALPHA-HYDROXYCHOLESTEROL price More Price(19)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | H6378 | 20α-Hydroxycholesterol analytical standard | 516-72-3 | 5mg | $170 | 2022-05-15 | Buy |
Cayman Chemical | 20103 | 20(S)-hydroxy Cholesterol ≥98% | 516-72-3 | 1mg | $44 | 2022-04-27 | Buy |
Cayman Chemical | 20103 | 20(S)-hydroxy Cholesterol ≥98% | 516-72-3 | 5mg | $98 | 2022-04-27 | Buy |
Cayman Chemical | 20103 | 20(S)-hydroxy Cholesterol ≥98% | 516-72-3 | 10mg | $173 | 2022-04-27 | Buy |
Tocris | 4474 | 20(S)-Hydroxycholesterol ≥95%(HPLC) | 516-72-3 | 10 | $184 | 2021-12-16 | Buy |
20ALPHA-HYDROXYCHOLESTEROL Chemical Properties,Uses,Production
Description
20(S)-hydroxy Cholesterol is an allosteric agonist of the smoothened (Smo) receptor that activates the hedgehog (Hh) signaling pathway with an EC50 value of approxiately 3 μM in a gene transcription reporter assay using NIH3T3 cells.1 20(S)-hydroxy Cholesterol is necessary for normal Hh signaling. It induces Smo accumulation in primary cilia, an early event in signaling, and binds to the extracellular, cysteine-rich domain of Smo.1,2 20(S)-hydroxy Cholesterol also stimulates osteogenic differentiation of pluripotent bone marrow stromal cells, a process mediated via Hh and Notch signaling.3,4,5
Chemical Properties
White Solid
Uses
A metabolite of Cholesterol (C432501). Cholesterol oxidation product having cytotoxicity effects.
Uses
A metabolite of Cholesterol (C432501). Cholesterol oxidation product having
Uses
A metabolite of Cholesterol. Cholesterol oxidation product having cytotoxicity effects
Definition
ChEBI: An oxysterol that is cholesterol substituted by a hydroxy group at position 20.
20ALPHA-HYDROXYCHOLESTEROL Preparation Products And Raw materials
Raw materials
Preparation Products
20ALPHA-HYDROXYCHOLESTEROL Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
Creative Enzymes | 631-6197922 | info@creative-enzymes.com | United States | 8748 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19231 | 58 |
J & K SCIENTIFIC LTD. | 010-82848833 400-666-7788 | jkinfo@jkchemical.com | China | 96815 | 76 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15877 | 69 |
Chemsky(shanghai)International Co.,Ltd. | 021-50135380 | shchemsky@sina.com | China | 32358 | 50 |
BOC Sciences | 16314854226 | info@bocsci.com | United States | 21113 | 65 |
Clearsynth Labs Limited | +91-22-26355700 | info@clearsynth.com | India | 9708 | 58 |
ChemStrong Scientific Co.,Ltd | 0755-66853366 15920483169 | sales@chem-strong.com | China | 18844 | 56 |
EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8454 | 60 |
Aikon International Limited | 025-58851090 13611564524 | sales01@aikonchem.com | China | 16029 | 58 |