ChemicalBook >> CAS DataBase List >>(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE structure

CAS No.: 451462-58-1

Chemical Name:: (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE

Synonyms: H1152;H1152P;H-1152;H 1152;H1152;(S)-H-1152 dihydrochloride;(S)-H-1152 (hydrochloride);(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE;4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride;Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl-;(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride

CBNumber:: CB2377081

Molecular Formula:: C16H21N3O2S

Molecular Weight:: 319.42

MDL Number:: MFCD07357272

MOL File:: 451462-58-1.mol

Last updated:2023-06-08 09:01:56

Request For Quotation

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Properties

Boiling point	519.6±60.0 °C(Predicted)
Density	1.218±0.06 g/cm3(Predicted)
storage temp.	Desiccate at +4°C
solubility	25℃: DMSO
form	Powder
pka	9.76±0.40(Predicted)

SAFETY

Risk and Safety Statements

Symbol(GHS)

GHS05,GHS07

Signal word

Danger

Hazard statements

H302-H315-H318-H335

Precautionary statements

P261-P280-P305+P351+P338

NFPA 704

	0
3		0

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Cayman Chemical	10007653	(S)-H-1152 (hydrochloride) ≥95%	451462-58-1	500μg	$36	2024-03-01	Buy
Cayman Chemical	10007653	(S)-H-1152 (hydrochloride) ≥95%	451462-58-1	1mg	$66	2024-03-01	Buy
Cayman Chemical	10007653	(S)-H-1152 (hydrochloride) ≥95%	451462-58-1	5mg	$274	2024-03-01	Buy
Cayman Chemical	10007653	(S)-H-1152 (hydrochloride) ≥95%	451462-58-1	10mg	$477	2024-03-01	Buy
AK Scientific	3714AH	(S)-4-Methyl-5-((2-methyl-1,4-diazepan-1-yl)sulfonyl)isoquinoline	451462-58-1	5mg	$402	2021-12-16	Buy

Product number	Packaging	Price	Buy
10007653	500μg	$36	Buy
10007653	1mg	$66	Buy
10007653	5mg	$274	Buy
10007653	10mg	$477	Buy
3714AH	5mg	$402	Buy

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Chemical Properties,Uses,Production

Description

Rho-associated kinase (ROCK), activated by GTP-linked Rho, phosphorylates targets that are involved in cytoskeletal remodeling, smooth muscle contraction, and neuronal development. H-1152 is a potent, specific, ATP-competitive, and cell permeable inhibitor of ROCK (K_i = 1.6 nM). It is a more potent inhibitor of ROCK than either Y-27632 (K_i = 140 nM) or HA-1077 (K_i = 330 nM). H-1152 poorly inhibits PKA, PKC, and myosin light chain kinase (K_i = 0.63, 9.27, and 10.1 μM, respectively). It has been used to examine the role of ROCK in such diverse processes as stress fiber assembly, vasoconstriction, as well as spontaneously tonic smooth muscle and neurite extension.

Definition

ChEBI: (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane is a member of the class of isoquinolines that is the sulfonamide formed by the formal condensation of the sulfo group of 4-methylisoquinoline-5-sulfonic acid with the 1-amino group of (S)-2-methyl-1,4-diazepane. It has a role as an EC 2.7.11.1 (non-specific serine/threonine protein kinase) inhibitor. It is a member of isoquinolines and a N-sulfonyldiazepane. It is a conjugate base of a (S)-2-methyl-1-(4-methylisoquinoline-5-sulfonyl)-1,4-diazepane(2+).

Biological Activity

Rho-kinase (ROCK) inhibitor that displays high selectivity over other protein kinases (IC 50 values are 0.012, 0.180, 0.360, 0.745, 3.03, 5.68 and 28.3 μ M for ROCKII, CAMKII, PKG, Aurora A, PKA, PKC and MLCK respectively). Inhibits sulprostone-induced contractions in guinea pig aorta (IC 50 = 190 nM) and displays proerectile effects in rats.

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Preparation Products And Raw materials

Raw materials

Preparation Products

(S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE Suppliers

Global( 47)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.	+86-057181025280; +8617767106207	sales@molcore.com	China	49739	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	52927	58
Shanghai Boyle Chemical Co., Ltd.		sales@boylechem.com	China	2923	55
3B Pharmachem (Wuhan) International Co.,Ltd.	821-50328103-801 18930552037	3bsc@sina.com	China	15848	69
VDM Biochemicals	0330-2528181	sales@vdmbio.com	United States	510	64
AdooQ BioScience, LLC	+1 (866) 930-6790	info@adooq.com	United States	2784	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	028-81700200 18116577057	3003855609@qq.com	China	7893	56
ShangHai KenEn Chemical Technology Co., Ltd.	13120367189	mychess007@163.com	China	1994	55
AdooQ Bioscience CHINA	025-58849295 18951903616;	info@adooq.cn	China	2989	60

Supplier	Advantage
Hangzhou MolCore BioPharmatech Co.,Ltd.	58
TargetMol Chemicals Inc.	58
Aladdin Scientific	58
Shanghai Boyle Chemical Co., Ltd.	55
3B Pharmachem (Wuhan) International Co.,Ltd.	69
VDM Biochemicals	64
AdooQ BioScience, LLC	58
Sichuan Wei Keqi Biological Technology Co., Ltd.	56
ShangHai KenEn Chemical Technology Co., Ltd.	55
AdooQ Bioscience CHINA	60

451462-58-1((S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE)Related Search:

H-9 DIHYDROCHLORIDE (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE H-8 DIHYDROCHLORIDE H-1152Glycyl, Dihydrochloride FASUDIL

(S)-(+)-2-Methyl-1-[(4-methyl-5-isoquinolinyl)sulfonyl]-hexahydro-1H-1,4-diazepinedihydrochloride H1152 H1152P (S)-(+)-2-METHYL-1-[(4-METHYL-5-ISOQUINOLYNYL)SULFONYL]HOMOPIPERAZINE (S)-H-1152 (hydrochloride) (S)-H-1152 dihydrochloride H-1152;H 1152;H1152 4-methyl-5-[(2-methyl-1,4-diazepan-1-yl)sulfonyl]isoquinoline,dihydrochloride Isoquinoline, 5-[[(2S)-hexahydro-2-methyl-1H-1,4-diazepin-1-yl]sulfonyl]-4-methyl- 451462-58-1 C16H21N3O2S2HCl Angiogenesis and Metastasis Intracellular signaling SiChem