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3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene structure
CAS No.
13669-70-0
Chemical Name:
3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
Synonyms
NEFOPAM;Nefopan;Nefopami;fenazoxine;HCL Nefopam;(?)-Nefopam;NEFOPAMI HCL;Induced insect;Nefopam HCL CP2000;Nefopanhydrochloride
CBNumber:
CB2379272
Molecular Formula:
C17H19NO
Formula Weight:
253.34
MOL File:
13669-70-0.mol

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Properties

Boiling point:
396.54°C (rough estimate)
Density 
1.0078 (rough estimate)
refractive index 
1.5400 (estimate)
storage temp. 
Sealed in dry,2-8°C
pka
9.16±0.70(Predicted)
CAS DataBase Reference
13669-70-0(CAS DataBase Reference)
FDA UNII
4UP8060B7J
ATC code
N02BG06

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Chemical Properties,Uses,Production

Originator

Ajan,Kettelhack Riker,W. Germany,1976

Uses

Analgesic.

Manufacturing Process

The starting material is prepared by reacting 2-benzoylbenzoic acid with thionyl chloride and then with 2-methylaminoethanol. 20.0 grams (0.07 mol) of N-(2-hydroxyethyl)-N-methyl-o-benzoylbenzamide is suspended in 100 ml tetrahydrofuran and then slowly added in small portions to a solution of 5.5 grams (0.14 mol) of lithium aluminum hydride in 150 ml tetrahydrofuran with cooling and stirring. The mixture is then refluxed for 18 hours, cooled and then to it is successively added 5.5 ml water, 5.5 ml of 3.75 N sodium hydroxide and 16 ml water. After removal of precipitated salts by filtration, the solution remaining is concentrated under reduced pressure and the residue dried to yield 19.5 grams of crude product. Yield after conversion to the hydrochloride salt and recrystallization is 17.0 grams (89%), MP 128° to 133°C.
5-methyl-1-phenyl-1,3,4,6-tetrahydro-5H-benz[f] -2,5-oxazocine is prepared as follows. 3.0 grams (0.011 mol) of 2-([N-(2-hydroxyethyl)-Nmethyl]amino)methylbenzhydrol, prepared as described above, 3.0 grams ptoluenesulfonic acid and 15 ml benzene are heated together with stirring until all the benzene is distilled off. The residual oil is heated to 105°C and held at this temperature for 1 hour, then cooled and dissolved in 30 ml water. This aqueous solution is then basified to pH 10.0 with 12 N sodium hydroxide, extracted with ether, and the extracts washed with water, dried over anhydrous sodium sulfate and the solvent removed under reduced pressure. The 2.26 grams (81%) oil remaining is converted to the hydrochloride salt, MP 238° to 242°C.

brand name

Acupan (3M Pharmaceuticals).

Therapeutic Function

Muscle relaxant, Antidepressant

3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Preparation Products And Raw materials

Raw materials

Preparation Products


3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene Suppliers

Global( 79)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28229 58
Alchem Pharmtech,Inc.
8485655694
sales@alchempharmtech.com United States 63726 58
CONIER CHEM AND PHARMA LIMITED
86-18523575427
sales@conier.com CHINA 47498 58
career henan chemical co
13203830695 0086-371-86658258
0086-371-86658258 factory@coreychem.com CHINA 29864 58
Shaanxi Dideu Medichem Co. Ltd
13772537765
029-88380327 1010@dideu.com CHINA 3993 58
Dideu Industries Group Limited
029-88380327
Service@dideu.com CHINA 30014 58
AFINE CHEMICALS LIMITED
008657185134551
008657185134895 info@afinechem.com CHINA 15559 58
Jiangsu Monade Biological Technology Co., Ltd.
+8613857751219
gao@mndbio.com CHINA 240 58
Shenzhen Sendi Biotechnology Co.Ltd. 0755-23311925 18102838259
0755-23311925 Abel@chembj.com CHINA 3194 55
Mainchem Co., Ltd. +86-0592-6210733
+86-0592-6210733 sale@mainchem.com CHINA 32439 55

View Lastest Price from 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2021-10-29 Nefopam
13669-70-0
US $0.00 / ASSAYS 100ASSAYS 99.99% 10000 Jiangsu Monade Biological Technology Co., Ltd.
2021-07-20 Nefopami
13669-70-0
US $1.00-1.00 / Kg/Bag 1g 99% 50tons Shaanxi Dideu Medichem Co. Ltd
2021-06-11 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP
13669-70-0
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited

13669-70-0(3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene)Related Search:


  • NEFOPAM
  • 3-methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene
  • 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-2,5-benzoxazocine
  • 3,4,5,6-tetrahydro-5-methyl-1-phenyl-1h-5-benzoxazocine
  • fenazoxine
  • NEFOPAMI HCL
  • Nefopam HCL CP2000
  • Nefopanhydrochloride
  • Nefopami hydrochloride
  • Nefopami
  • Nefopam (base and/or unspecified salts)
  • 1H-2,5-Benzoxazocine,3,4,5,6-tetrahydro-5-Methyl-1-phenyl-
  • 5-Methyl-1-phenyl-3,4,5,6-tetrahydro-1H-benzo[f][1,4]oxazocine
  • Nefopan
  • HCL Nefopam
  • Induced insect
  • (?)-Nefopam
  • 3-Methyl-7-phenyl-6-oxa-3-azabicyclo[6.4.0]dodeca-8,10,12-triene USP/EP/BP
  • 13669-70-0
  • 156-2-24
  • C17H19NO
  • ACTIVE PHARMACEUTICAL INGREDIENTS
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