3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
![3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Structure](CAS/GIF/40254-90-8.gif)
- CAS No.
- 40254-90-8
- Chemical Name:
- 3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE
- Synonyms
- NSC 693868;Brimonidine Impurity 8;Cdk1/5 Inhibitor inhibitor;3-Aminopyrazolo[3,4-b]quinoxaline;1H-PYRAZOLO[3,4-B]QUINOXALIN-3-AMINE;3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE;1H-Pyrazolo[3,4-b]quinoxalin-3-ylamine;1H-Pyrazolo[3,4-b]quinoxalin-3-amine(9CI);Cdk1/5 Inhibitor - CAS 40254-90-8 - Calbiochem
- CBNumber:
- CB2381002
- Molecular Formula:
- C9H7N5
- Molecular Weight:
- 185.19
- MDL Number:
- MFCD04038461
- MOL File:
- 40254-90-8.mol
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE price More Price(14)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | 217720 | Cdk1/5 Inhibitor | 40254-90-8 | 5mg | $238 | 2023-01-07 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 1mg | $49 | 2024-03-01 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 5mg | $120 | 2024-03-01 | Buy |
| Cayman Chemical | 18740 | Cdk1/5 Inhibitor ≥95% | 40254-90-8 | 10mg | $216 | 2024-03-01 | Buy |
| TRC | N900555 | NSC693868 | 40254-90-8 | 10mg | $180 | 2021-12-16 | Buy |
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Chemical Properties,Uses,Production
Description
Cyclin-dependent kinases (Cdks) are key regulators of cell cycle progression and are therefore promising targets for cancer therapy. Cdk1/5 Inhibitor is a pyrazolo [3,4-b] quioxaline that inhibits Cdk1/cyclin B and Cdk5/p25 (IC50s = 600 and 400 nM, respectively). It less potently inhibits GSK3β (IC50 = 1 μM) and does not block Cdc25 activity. This compound is used to help define the roles of Cdk1 and Cdk5 in various signaling pathways.
Uses
Cyclin-dependent kinases (CDKs) are protein kinases and involved with the regulation of the cell cycle. NSC 693868 is an inhibitor of Cdk1/cyclin B and Cdk5/p25.?Small molecules that target these protein kinases are valuable tools for investigating cellular signaling pathways and are potential therapeutic agents.
Definition
ChEBI: 2H-pyrazolo[4,3-b]quinoxalin-3-amine is a quinoxaline derivative.
Biological Activity
Inhibitor of cyclin-dependent kinases (cdks) and glycogen synthase kinase-3 (GSK-3). IC 50 values are 0.6, 0.4 and 1 μ M for cdk1/cyclin B, cdk5/p25 and GSK-3 respectively.
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Preparation Products And Raw materials
3-AMINO-1H-PYRAZOLO[3,4-B]QUINOXALINE Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| Hangzhou MolCore BioPharmatech Co.,Ltd. | +86-057181025280; +8617767106207 | sales@molcore.com | China | 49739 | 58 |
| ZHEJIANG JIUZHOU CHEM CO., LTD | +86-0576225566889 +86-13454675544 | admin@jiuzhou-chem.com；jamie@jiuzhou-chem.com；alice@jiuzhou-chem.com | China | 20000 | 58 |
| Aladdin Scientific | +1-833-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
| 3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
| EMMX Biotechnology LLC | 888-539-0666 | info@emmx.com | United States | 8449 | 60 |
| BOC Sciences | -- | info@bocsci.com | USA | 0 | 65 |
| Jinan blalong chemical co. LTD | 2710913286@.com | 1513643261@qq.com | China | 14253 | 58 |
| ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
| MedBioPharmaceutical Technology Inc | 021-69568360 18916172912 | order@med-bio.cn | China | 8141 | 58 |