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9-CIS-RETINOIC ACID

9-CIS-RETINOIC ACID
9-CIS-RETINOIC ACID structure
CAS No.
5300-03-8
Chemical Name:
9-CIS-RETINOIC ACID
Synonyms
Toctino;LGD 1057;Panretin;Panretyn;NSC 659772;ALIRETINOIN;Alitretinoin;9-cis-tretinoi;9-CIS-TRETINOIN;RARECHEM AL BE 0738
CBNumber:
CB2386395
Molecular Formula:
C20H28O2
Formula Weight:
300.44
MOL File:
5300-03-8.mol

9-CIS-RETINOIC ACID Properties

Melting point:
189-191°C
RTECS 
VH6450000
storage temp. 
−20°C
Water Solubility 
Soluble in chloroform (50 mg/ml), DMSO (~25 mg/ml), ethanol (25 mg/ml), and acetone (25 mg/ml). Insoluble in water.
Sensitive 
Moisture & Light Sensitive
Stability:
Store Dry in Freezer at -20°C for up to 1 year; in Solution at -20°C for up to 3 Months.
CAS DataBase Reference
5300-03-8(CAS DataBase Reference)
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  T
Risk Statements  61-36/37/38
Safety Statements  53-26-36/37/39-45
WGK Germany  3
HS Code  29162090
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H315 Causes skin irritation Skin corrosion/irritation Category 2 Warning P264, P280, P302+P352, P321,P332+P313, P362
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H335 May cause respiratory irritation Specific target organ toxicity, single exposure;Respiratory tract irritation Category 3 Warning
H360 May damage fertility or the unborn child Reproductive toxicity Category 1A, 1B Danger
Precautionary statements:
P201 Obtain special instructions before use.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P280 Wear protective gloves/protective clothing/eye protection/face protection.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.
P405 Store locked up.

9-CIS-RETINOIC ACID price More Price(5)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Alfa Aesar J62219 9-cis-Retinoic acid 5300-03-8 5mg $233 2018-11-13 Buy
Cayman Chemical 14587 9-cis-Retinoic Acid ≥95% 5300-03-8 1mg $39 2018-11-13 Buy
Cayman Chemical 14587 9-cis-Retinoic Acid ≥95% 5300-03-8 5mg $107 2018-11-13 Buy
Cayman Chemical 14587 9-cis-Retinoic Acid ≥95% 5300-03-8 10mg $195 2018-11-13 Buy
Cayman Chemical 14587 9-cis-Retinoic Acid ≥95% 5300-03-8 25mg $390 2018-11-13 Buy

9-CIS-RETINOIC ACID Chemical Properties,Uses,Production

Description

Alitretinoin was introduced in the US for the topical treatment of cutaneous lesions in patients with Kaposi's sarcoma (KS), the most frequent malignancy observed in AIDS patients. It is a derivative of 9-cis-retinoic acid (9- cis-RA) identified as an endogenous hormone in mammalian tissues. Alitretinoin binds to all isoforms of the intracellular retinoid X (RXR) and retinoid A (RAR) receptors thus inducing cell differentiation, increasing cell apoptosis and inhibiting cellular proliferation in experimental models of human cancer. In an international phase III trial in patients with KS, 42% of 82 patients treated with 0.1% gel formulation experienced complete or partial responses cf 7% for controls. Alitretinoin is the first topical therapy for KS and is expected to be a new option to its traditional management.

Chemical Properties

Pale Yellow Solid

Originator

Ligand (US)

Uses

An endogenous retinoic acid isomer, which is capable of binding to both retinoic acid receptors (RAR) and retinoid X receptors (RXR). A biologically active ligand for members of the RAR and RXR subfamilies, implying that it may play a critical role in regulating retinoid-responsive pathways.

Definition

ChEBI: A retinoic acid in which the exocyclic double bonds have 7E,9Z,11E,13E geometry.

brand name

Panretin (Ligand).

9-CIS-RETINOIC ACID Preparation Products And Raw materials

Raw materials

Preparation Products


9-CIS-RETINOIC ACID Suppliers

Global( 62)Suppliers
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Henan DaKen Chemical CO.,LTD.
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