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Elastase

CAS No.
9004-06-2
Chemical Name:
Elastase
Synonyms
ELA2;ELANE;elaszym;ELASTASE;Eiastase;Elastase-2;e.c.3.4.4.7;Elastase ES;EC 3.4.21.37;EC 3.4.21.36
CBNumber:
CB2398822
Molecular Formula:
Molecular Weight:
0
MDL Number:
MFCD00130997
MOL File:
Mol file
MSDS File:
SDS
Last updated:2023-04-23 13:52:06

Elastase Properties

storage temp. -20°C
form lyophilized powder
CAS DataBase Reference 9004-06-2
EWG's Food Scores 1
FDA UNII U2974059LF
EPA Substance Registry System Elastase (9004-06-2)

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Danger
Hazard statements  H315-H319-H334-H335
Precautionary statements  P261-P264-P271-P302+P352-P304+P340+P312-P305+P351+P338
Hazard Codes  B
WGK Germany  3
3-10

Elastase price More Price(9)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich SAB1305716 ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit affinity isolated antibody, buffered aqueous solution 9004-06-2 400μl $481 2024-03-01 Buy
Sigma-Aldrich E8140 Elastase from human leukocytes lyophilized powder, ≥50?units/mg protein (Bradford) 9004-06-2 1unit $228 2024-03-01 Buy
Sigma-Aldrich 324681 Elastase, Human Neutrophil Elastase, Human Neutrophil, CAS 9004-06-2, is a serine protease that degrades elastin, collagen, and proteoglycans 9004-06-2 50μg $318 2024-03-01 Buy
Sigma-Aldrich 324681 Elastase, Human Neutrophil Elastase, Human Neutrophil, CAS 9004-06-2, is a serine protease that degrades elastin, collagen, and proteoglycans 9004-06-2 100μg $513 2024-03-01 Buy
Usbiological E2255-25 Elastase, Human Neutrophil 9004-06-2 100ug $583 2021-12-16 Buy
Product number Packaging Price Buy
SAB1305716 400μl $481 Buy
E8140 1unit $228 Buy
324681 50μg $318 Buy
324681 100μg $513 Buy
E2255-25 100ug $583 Buy

Elastase Chemical Properties,Uses,Production

Uses

Elastase from human leukocytes has been used:

  • to measure serum elastase activity
  • in proteolytic digestion of fibronectin and salivary glands
  • in neutrophil elastase (NE) activity assay
  • cell-free NE digestion of E-cadherin
  • scratch wound assay
  • in a study that determined that fragments of Nle3-angiotensin(1-7) accelerate healing in dermal models
Elastase has been used to digest fibronectin. The results were compared with fibronectin digestion by crude human leukocyte homogenate to examine the presence of fibronectin peptides in saliva of patients with Sj?gren′s syndrome. It has also been used as a reference to determine the elastase activity in cell lysates. This study examined the effect of all-trans retinoic acid on procoagulant and fibrinolytic activities of cultured blast cells. These blast cells were from patients with acute promyelocytic leukemia.

General Description

Elastase is a proteolytic enzyme. It is a member of the subgroup named, peptidyl peptide hydrolases. It is a major anatomic constituent of arteries. It is mainly found in the pancreas and pancreatic juice of various birds and mammals. It is also present in human serum, granulocytes and erythrocytes.

Biochem/physiol Actions

Elastase enzyme is capable of releasing soluble peptides from insoluble elastin fibers with the help of a proteolytic process. It can stimulate disintegration of the axoneme with the help of adenosine triphosphate (ATP). Unlike pancreatic elastase the leukocyte enzyme has a preferential cleavage for the carboxyl side of valine, but will also cleave to a lesser extent after alanine. Natural substrates include elastin, cartilage proteoglycans, collagen types I, II, II and IV, and fibronectin.

Elastase Preparation Products And Raw materials

Raw materials

Preparation Products

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PANCREATOPEPTIDASE E LYSOSOMAL ELASTASE macrophage metalloelastase EC 3.4.21.36 EC 3.4.21.37 ELASTASE ELASTASE, LEUKOCYTE ELASTASE, NEUTROPHIL, HUMAN ELASTASE, HUMAN NEUTROPHIL ELASTASE, HUMAN NEUTROPHILS elaszym LEUKOCYTE ELASTASE, HUMAN NEUTROPHILS e.c.3.4.4.7 elastolytic enzyme pancre-atopeptidase elastase from human leukocytes Eiastase ELASTASE, LEUKOCYTE FROM HUMAN*LEUKOCYTE S ELASTASE 2X-CRYSTALLIZED ELASTASE FROM PORCINE PANCREAS LYOPHILIZED POWDER ELASTASE FROM HUMAN NEUTROPHILS (WHITE LEUCOCYTES)ACTIVITY: 18-30 UNITS/MG PROTEIN SALT-FREE, LYOPHILIZED SOLID 98% BY SDS-PAGE Elastase ES 3-(4-hydroxy-2,3-dimethoxy-phenyl)-3,4-dihydro-2H-chromen-7-ol 3-(4-hydroxy-2,3-dimethoxyphenyl)-3,4-dihydro-2H-chromen-7-ol 3-(4-hydroxy-2,3-dimethoxy-phenyl)chroman-7-ol Elastase from human neutrophils min. 10 U/mg ANTI-NEUTROPHIL ELASTASE(N-TERMINAL) antibody produced in rabbit Bone marrow serine protease ELA2 ELANE Elastase-2 Elastasefromhumanneutrophils(whiteleucocytes),activity:18-30u/mgproteinsalt-free,lyophilizedsolid fromporcinepancreaslyophilizedpowder Elastase from porcine pancreas, lyophil. Elastase froM huMan neutrophils Min. 10 U/Mg lyophil. neutrophil elastase Elastase, human leucocytes 9004-06-2 9004-02-6 9004-6-2 Enzymes, Inhibitors, and Substrates BioChemical Biochemicals and Reagents Proteolytic Enzymes and Substrates Proteolytic Enzymes