7-(Trifluoromethyl)indoline-2,3-dione
- CAS No.
- 391-12-8
- Chemical Name:
- 7-(Trifluoromethyl)indoline-2,3-dione
- Synonyms
- 7-(TRIFLUOROMETHYL)ISATIN;7-(TRIFLUOROMETHYL)-1H-INDOLE-2,3-DIONE;7-TRIFLUOROMET;7-Trifluoroisatin;BUTTPARK 24\07-40;7-TRIFLUOROMETHYLINDOLE;7-(Trifluoromethyl)isatin 98%;7-(Trifluoromethyl)isatin,97%;1,4,7-trifluoroindole-2,3-dione;7-(trifluoromethyl)indole-2,3-dione
- CBNumber:
- CB2406138
- Molecular Formula:
- C9H4F3NO2
- Molecular Weight:
- 215.13
- MDL Number:
- MFCD01248408
- MOL File:
- 391-12-8.mol
| Product description | Number | Pack Size | Price |
| 7-(Trifluoromethyl)isatin >98.0%(GC)(T) | T2457 | 1g | $20 |
| 7-(Trifluoromethyl)isatin >98.0%(GC)(T) | T2457 | 5g | $64 |
| 7-(Trifluoromethyl)1H-indole-2,3-dione | T791300 | 10g | $50 |
| 7-(Trifluoromethyl)isatin 98% | PC1776 | 5g | $53 |
| 7-(Trifluoromethyl)isatin 98% | 4H17-3-17 | 5G | $85 |
| More product size | |||
| Melting point | 192-193 |
|---|---|
| Density | 1.525±0.06 g/cm3(Predicted) |
| storage temp. | Keep in dark place,Sealed in dry,Room Temperature |
| solubility | DMSO (Slightly), Methanol (Slightly) |
| form | Solid |
| pka | 9.43±0.20(Predicted) |
| color | Very Dark Yellow to Brown |
| InChI | InChI=1S/C9H4F3NO2/c10-9(11,12)5-3-1-2-4-6(5)13-8(15)7(4)14/h1-3H,(H,13,14,15) |
| InChIKey | MXLDJTXXAYVWDF-UHFFFAOYSA-N |
| SMILES | N1C2=C(C=CC=C2C(F)(F)F)C(=O)C1=O |
| CAS DataBase Reference | 391-12-8(CAS DataBase Reference) |
| FDA UNII | RLA848X4KR |
7-(Trifluoromethyl)indoline-2,3-dione price More Price(23)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| TCI Chemical | T2457 | 7-(Trifluoromethyl)isatin >98.0%(GC)(T) | 391-12-8 | 1g | $20 | 2025-07-31 | Buy |
| TCI Chemical | T2457 | 7-(Trifluoromethyl)isatin >98.0%(GC)(T) | 391-12-8 | 5g | $64 | 2025-07-31 | Buy |
| TRC | T791300 | 7-(Trifluoromethyl)1H-indole-2,3-dione | 391-12-8 | 10g | $50 | 2021-12-16 | Buy |
| Apolloscientific | PC1776 | 7-(Trifluoromethyl)isatin 98% | 391-12-8 | 5g | $53 | 2021-12-16 | Buy |
| SynQuest Laboratories | 4H17-3-17 | 7-(Trifluoromethyl)isatin 98% | 391-12-8 | 5G | $85 | 2021-12-16 | Buy |
7-(Trifluoromethyl)indoline-2,3-dione Chemical Properties,Uses,Production
Chemical Properties
7-(Trifluoromethyl)indoline-2,3-dione is Brown Solid
Uses
7-(Trifluoromethyl)indoline-2,3-dione is an indole derivative as inhibitor of COX-1, COX-2, and ?catenin.Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer disease.
Uses
An indole derivative as inhibitor of COX-1, COX-2, and β-catenin. Useful in the treatment of diseases such as: lung cancer, diabetes and Alzheimer''s disease.
Synthesis
444-93-9
391-12-8
General procedure: Concentrated sulfuric acid (95 mL) was preheated in a thermostatic flask at 60 °C. Intermediate 2 ((2E)-2-(hydroxyimino)-N-[2-(trifluoromethyl)phenyl]acetamide, 12 g, 52 mmol) was added slowly in batches while keeping the reaction temperature below 70 °C. Subsequently, the temperature of the reaction system was raised to 80°C for 3 hours. Upon completion of the reaction, the mixture was cooled to room temperature and quenched by slow pouring into crushed ice under vigorous stirring. The precipitated solid precipitate was collected by filtration and dried in a vacuum drying oven to give the final product 3 (7-(trifluoromethyl)dihydroindole-2,3-dione).
References
[1] Chinese Chemical Letters, 2017, vol. 28, # 6, p. 1248 - 1251
[2] ACS Medicinal Chemistry Letters, 2013, vol. 4, # 1, p. 22 - 26
[3] Journal of Medicinal Chemistry, 2010, vol. 53, # 16, p. 6003 - 6017
7-(Trifluoromethyl)indoline-2,3-dione Preparation Products And Raw materials
Raw materials
Preparation Products
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Hebei Chuanghai Biotechnology Co., Ltd | +8615350571055 | Sibel@chuanghaibio.com | China | 8772 | 58 |
| Shaanxi Dideu Medichem Co. Ltd | +86-029-81138252 +86-173 9270 1263 | 1057@dideu.com | China | 3999 | 58 |
| PNP Biotech Co. Ltd | +8618516098983 | sales@pnpbiotech.com | China | 1001 | 58 |
| Henan Fengda Chemical Co., Ltd | +86-371-86557731 +86-13613820652 | info@fdachem.com | China | 20174 | 58 |
| Capot Chemical Co.,Ltd. | +86-（0）57185586718; +8613336195806 | sales@capot.com | China | 29735 | 60 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28172 | 58 |
| Changzhou Ditong Chemical Co.,Ltd | +86-0519-88299272 | info@edengenechem.com | China | 2176 | 58 |
| Alchem Pharmtech,Inc. | 8485655694 | sales@alchempharmtech.com | United States | 63687 | 58 |
| Wuhan Chemwish Technology Co., Ltd | 027-67849912 | sales@chemwish.com | CHINA | 10821 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 49975 | 58 |
View Lastest Price from 7-(Trifluoromethyl)indoline-2,3-dione manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2025-10-21 | 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
|
US $0.00-0.00 / KG | 1KG | 99% | 20 mt | Hebei Chuanghai Biotechnology Co., Ltd | |
 |
2025-09-25 | 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
|
US $36.00-1.50 / kg | 1kg | 99% | g-kg-tons, free sample is available | Henan Fengda Chemical Co., Ltd | |
 |
2024-06-26 | 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
|
US $1.00 / KG | 1KG | 99% | 20t | Shaanxi Dideu Medichem Co. Ltd |
-
- 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
- US $0.00-0.00 / KG
- 99%
- Hebei Chuanghai Biotechnology Co., Ltd
-
- 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
- US $36.00-1.50 / kg
- 99%
- Henan Fengda Chemical Co., Ltd
-
- 7-(Trifluoromethyl)indoline-2,3-dione
391-12-8
- US $1.00 / KG
- 99%
- Shaanxi Dideu Medichem Co. Ltd
