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Ascomycin

Ascomycin
Ascomycin structure
CAS No.
104987-12-4
Chemical Name:
Ascomycin
Synonyms
AAG;FK-520;FR 520;C058028;L 683590;FR-900520;Ascomycin;IMMUNOMYCIN;Changchuanmycin;AscoMycin solution
CBNumber:
CB2406330
Molecular Formula:
C43H69NO12
Formula Weight:
792.01
MOL File:
104987-12-4.mol

Ascomycin Properties

Melting point:
153-157°C
Boiling point:
868℃
Flash point:
>110°(230°F)
storage temp. 
−20°C
Water Solubility 
Soluble in DMSO at 65mg/ml; soluble in ethanol at 50mg/m; with warming. Very poorly soluble in water
SAFETY
  • Risk and Safety Statements
  • Hazard and Precautionary Statements (GHS)
Hazard Codes  Xn,F
Risk Statements  20/21/22-36-11
Safety Statements  36/37-16
RIDADR  UN 1648 3 / PGII
WGK Germany  3
RTECS  KD4185000
10
HS Code  29419090
Symbol(GHS):
Signal word: Danger
Hazard statements:
Code Hazard statements Hazard class Category Signal word Pictogram P-Codes
H225 Highly Flammable liquid and vapour Flammable liquids Category 2 Danger P210,P233, P240, P241, P242, P243,P280, P303+ P361+P353, P370+P378,P403+P235, P501
H302 Harmful if swallowed Acute toxicity,oral Category 4 Warning P264, P270, P301+P312, P330, P501
H312 Harmful in contact with skin Acute toxicity,dermal Category 4 Warning P280,P302+P352, P312, P322, P363,P501
H319 Causes serious eye irritation Serious eye damage/eye irritation Category 2A Warning P264, P280, P305+P351+P338,P337+P313P
H332 Harmful if inhaled Acute toxicity,inhalation Category 4 Warning P261, P271, P304+P340, P312
Precautionary statements:
P210 Keep away from heat/sparks/open flames/hot surfaces. — No smoking.
P261 Avoid breathing dust/fume/gas/mist/vapours/spray.
P321 Specific treatment (see … on this label).
P304+P340 IF INHALED: Remove victim to fresh air and Keep at rest in a position comfortable for breathing.
P305+P351+P338 IF IN EYES: Rinse cautiously with water for several minutes. Remove contact lenses, if present and easy to do. Continuerinsing.

Ascomycin price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich A-094 Ascomycin solution 1.0mg/mL in acetonitrile, ampule of 1mL, certified reference material 104987-12-4 094-1ml $207 2018-11-20 Buy
Sigma-Aldrich A3835 Ascomycin from Streptomyces hygroscopicus var. ascomyceticus 104987-12-4 1mg $212 2018-11-20 Buy
Alfa Aesar J66751 Ascomycin, 95% 104987-12-4 100mg $491 2018-11-13 Buy
Alfa Aesar J66751 Ascomycin, 95% 104987-12-4 25mg $160 2018-11-13 Buy
Cayman Chemical 11309 Ascomycin ≥98% 104987-12-4 5mg $39 2018-11-13 Buy

Ascomycin Chemical Properties,Uses,Production

Chemical Properties

White Solid

Uses

A potent immunosuppressive agent and could be used as a potential therapeutic agent for autoimmune diseases

Uses

Ascomycin is a macrocyclic lactone closely related to tacrolimus and rapamycin. Ascomycin is isolated from several species of Streptomyces and was first reported in 1988. Ascomycin exhibits limited, potent antifungal activity but has found considerable utility as an immunosuppressant.

Uses

Ascomycin is a macrocyclic lactone closely related to tacrolimus and rapamycin. Ascomycin is isolated from several species of Streptomyces and was first reported in 1962. Ascomycin exhibits limited, potent antifungal activity but has found considerable utility as an immunosuppressant.

Uses

Everolimus is a semi-synthetic macrocyclic lactone prepared from rapamycin by selective alkylation of the 42-hydroxy group with a silyl-protected hydroxyethyl triflate moiety, followed by addition of an ethylhydroxy moiety to provide greater stability and bioavailability. Like all tacrolimus analogues, everolimus binds to receptor protein, FKBP12. The complex then binds to mTOR preventing it from interacting with target proteins. Everolimus is extensively cited in the literature with over 2,000 citations.

Definition

ChEBI: A macrolide that is produced by the fermentation of Streptomyces hygroscopicus and exhibits strong immunosuppressant properties.

Ascomycin Preparation Products And Raw materials

Raw materials

Preparation Products


Ascomycin Suppliers

Global( 100)Suppliers
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ATK CHEMICAL COMPANY LIMITED
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QUALITY CONTROL CHEMICALS INC.
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China DongFan Chemical Co.,LTD 86-0571-85151182
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