Sesamol
- CAS No.
- 533-31-3
- Chemical Name:
- Sesamol
- Synonyms
- benzo[d][1,3]dioxol-5-ol;SesaMe phenol;1,3-BENZODIOXOL-5-OL;5-BENZODIOXOLOL;3,4-METHYLENEDIOXYPHENOL;SESAMOL;Sesamolr;NSC 59256;S**Sesamol;Sesamol>
- CBNumber:
- CB2413594
- Molecular Formula:
- C7H6O3
- Molecular Weight:
- 138.12
- MDL Number:
- MFCD00005827
- MOL File:
- 533-31-3.mol
- MSDS File:
- SDS
| Melting point | 62-65 °C (lit.) |
|---|---|
| Boiling point | 113-116°C 2mm |
| Density | 1.2112 (rough estimate) |
| refractive index | 1.4850 (estimate) |
| Flash point | 113-116°C/2mm |
| storage temp. | Keep in dark place,Inert atmosphere,Room temperature |
| solubility | Chloroform, Methanol |
| form | crystalline |
| pka | 10.08±0.20(Predicted) |
| color | off-white to tan |
| Water Solubility | slightly soluble |
| Sensitive | Light Sensitive |
| BRN | 127405 |
| InChIKey | LUSZGTFNYDARNI-UHFFFAOYSA-N |
| LogP | 1.253 (est) |
| CAS DataBase Reference | 533-31-3(CAS DataBase Reference) |
| EWG's Food Scores | 1-4 |
| FDA UNII | 94IEA0NV89 |
| NIST Chemistry Reference | 1,3-Benzodioxol-5-ol(533-31-3) |
| EPA Substance Registry System | Sesamol (533-31-3) |
Sesamol price More Price(52)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | S3003 | Sesamol 98% | 533-31-3 | 5G | $38.5 | 2024-03-01 | Buy |
| Sigma-Aldrich | S3003 | Sesamol 98% | 533-31-3 | 25g | $88.4 | 2024-03-01 | Buy |
| Sigma-Aldrich | PHL80111 | Sesamol phyproof? Reference Substance | 533-31-3 | 50MG | $262 | 2024-03-01 | Buy |
| Sigma-Aldrich | 41557 | Sesamol analytical standard | 533-31-3 | 100mg | $74.7 | 2022-05-15 | Buy |
| TCI Chemical | S0418 | Sesamol >98.0%(GC) | 533-31-3 | 25g | $66 | 2024-03-01 | Buy |
Sesamol Chemical Properties,Uses,Production
Description
Sesamol is found in sesame seeds and sesame oil. It is a well-known antioxidant. It has antioxidant, chemoprevention, antimutagenic, and antihepatotoxic activities and can induce the apoptosis of cancer and cardiovascular cells. It can be used in the synthesis of paroxetine.
Reference
[1] M. A. Ansari, Z. Fatima, S. Hameed, Sesamol: A Natural Phenolic Compound with Promising Anticandidal Potential, Journal of Pathogens, vol. 2014, Article ID 895193.
[2] T. Geetha, B. Rohit, K. Pal, Sesamol: an efficient antioxidant with potential therapeutic benefits, Medicinal Chemistry, 2009, vol. 5, pp. 367-371.
[3] Amin F. Majdalawieh, Zeenah R. Mansour. “Sesamol, a major lignan in sesame seeds (Sesamum indicum): Anti-cancer properties and mechanisms of action.” European journal of pharmacology 855 (2019): Pages 75-89.
Chemical Properties
off-white to beige crystalline powder
Uses
Sesamol (Paroxetine Anhydrous EP Impurity B) is a natural component of sesame oil with antioxidant activity. Sesamol has potential protective effects against free radicals as well as some antifungal activity. Sesamol can also be used as an intermediate in the preparation of antidepressants such as Paroxetine (P205750).
Definition
ChEBI: Sesamol is a member of benzodioxoles.
benefits
Sesamol, 5-hydroxy-1,3-benzodioxole or 3,4-methylene-dioxyphenol, is a water-soluble phenolic lignan isolated from roasted sesame seeds and processed sesame oil. Various studies investigated the anti-cancer therapeutic potential of sesamol, and the literature provided reveals compelling evidence that sesamol acts as a metabolic regulator and possesses antioxidant, anti-mutagenic, anti-hepatotoxic, anti-inflammatory, anti-aging, and chemopreventive properties.
Synthesis Reference(s)
Tetrahedron Letters, 19, p. 3085, 1978 DOI: 10.1016/S0040-4039(01)94947-0
General Description
Sesamol, a principal phytophenol of sesame oil lignans, is typically used as a dietary compound.(10)
Biological Activity
Sesamol has a wide range of biological actions including inhibition of lipid peroxidation and enhancement of radical scavenging, upregulation of antioxidant enzymes, suppression of TNFα 80 and IL-1β expression, inhibition of NF-κB 81 signaling, suppression of LOX-1 82 and 5-LOX activity, induction of 83 apoptosis, arresting cell growth at different phases of the cell cycle; and modulation of caspase-3, p53, Bax, and Bcl2 expression[3].
Sesamol Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| .GZ HONESTCHEM CO.,LTD | +86-15013270415 | honestchemical@foxmail.com | China | 247 | 58 |
| TAIZHOU DKD CHEMICAL CO., LTD. | +8618658336633 | yf.chen@tzdkdchem.com | China | 134 | 58 |
| Hangzhou Zelixir Biotech Co., Ltd. | +8618867646786 | neal.chen@zelixir.com | China | 229 | 58 |
| Qingdao Dexin Chemical Co., Ltd | +8615553333686 | 15553333686@qq.com | China | 926 | 58 |
| Anhui Yiao New Material Technology Co., Ltd | +86-199-55145978 +8619955145978 | sales8@anhuiyiao.com | China | 253 | 58 |
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| Shaanxi Haibo Biotechnology Co., Ltd | +undefined18602966907 | qinhe02@xaltbio.com | China | 1000 | 58 |
| Anhui Ruihan Technology Co., Ltd | +8617756083858 | daisy@anhuiruihan.com | China | 994 | 58 |
| Hebei Saisier Technology Co., LTD | +86-18400010335 +86-13102810335 | admin@hbsaisier.cn | China | 772 | 58 |
| BINBO BIOLOGICAL CO.,LTD | +8618629063126 | info@binbobiological.com | China | 311 | 58 |
View Lastest Price from Sesamol manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-04-25 | Sesamol
533-31-3
|
US $0.00 / kg | 1kg | >98% | 1000 kg | BINBO BIOLOGICAL CO.,LTD | |
 |
2024-04-19 | Sesamol
533-31-3
|
US $50.00 / kg | 1kg | 99.10% | 5000kg | Ouhuang Engineering Materials (Hubei) Co., Ltd | |
 |
2024-04-16 | Sesamol
533-31-3
|
US $6.00 / KG | 1KG | 99% | 2000KG/MONTH | Hebei Saisier Technology Co., LTD |