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Naphazoline

Naphazoline Structure
Naphazoline structure
CAS No.
835-31-4
Chemical Name:
Naphazoline
Synonyms
NAPHAZOLINE HCL;Naphazoline-d4;2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE;Antan;Imidin;Privine;Sanorin;Rhinazine;NAFAZOLINE;ciba2020/r
CBNumber:
CB2414016
Molecular Formula:
C14H14N2
Molecular Weight:
210.27
MDL Number:
MFCD00066737
MOL File:
835-31-4.mol
Last updated:2023-09-04 15:51:00
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Naphazoline Properties

Melting point 254 °C
Boiling point 339.81°C (rough estimate)
Density 1.1063 (rough estimate)
refractive index 1.6180 (estimate)
storage temp. 2-8°C
pka pKa 10.35 ± 0.02(H2O,t =25,Iundefined) (Uncertain)
CAS DataBase Reference 835-31-4(CAS DataBase Reference)
EWG's Food Scores 1-3
FDA UNII H231GF11BV
ATC code R01AA08,R01AB02,S01GA01,S01GA51
NIST Chemistry Reference Naphazoline(835-31-4)

SAFETY

Risk and Safety Statements

Hazard Codes  T
Risk Statements  25
Safety Statements  45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  NJ4375000

Naphazoline price

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
American Custom Chemicals Corporation RDL0006964 NAPHAZOLINE-D4 95.00% 835-31-4 5MG $495.33 2021-12-16 Buy
Chemenu CM128968 2-(naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole 95% 835-31-4 1g $259 2021-12-16 Buy
Crysdot CD33000071 Naphazoline 95+% 835-31-4 1g $274 2021-12-16 Buy
Product number Packaging Price Buy
RDL0006964 5MG $495.33 Buy
CM128968 1g $259 Buy
CD33000071 1g $274 Buy

Naphazoline Chemical Properties,Uses,Production

Originator

Privine,Ciba,US,1942

Uses

Naphazoline is used in severe rhinitis associated with colds, allergic reactions, and severe and chronic inflammatory conditions, in particular for inflammation of the antrum of Highmore as well as for stopping nosebleeds.

Uses

Adrenergic (vasoconstrictor).

Definition

ChEBI: 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole is a member of naphthalenes.

Manufacturing Process

2.7 parts of naphthyl-(1)-acetiminoethylether hydrochloride of the formula (produced from naphthyl-(1)-acetonitrile and methanol) are dissolved in 12 parts of absolute alcohol. 1 part of ethylenediamine is then added and the whole is heated to gentle boiling while passing nitrogen through it and simultaneously stirring until ammonia escapes no longer. The alcohol is then distilled and the residue mixed with 40 parts of benzene and 1.8 parts of caustic potash. Stirring is continued for some time whereby the imidazoline base is dissolved in benzene. The benzene residue is recrystallized several times from toluene.

brand name

Albalon (Allergan); Nafazair (Bausch & Lomb); Nafazair (Pharmafair); Naphcon (Alcon); Opcon (Bausch & Lomb); Vasocon (Novartis).

Therapeutic Function

Nasal decongestant

Synthesis

Naphazoline, 2-(1-naphthylmethyl)-2-imidazoline (11.1.36), is synthesized from (1-naphthyl)acetonitrile, which upon reaction with ethanol transforms into iminoester (11.1.35), and undergoes further heterocyclization into the desired imidozoline derivative (11.1.36) upon reaction with ethylendiamine [40].

Synthesis_835-31-4

Naphazoline synthesis

86-87-3
107-15-3
835-31-4
Synthesis of Naphazoline from 1-Naphthaleneacetic acid and Ethylenediamine

Naphazoline Preparation Products And Raw materials

Raw materials

Methanol Ethanol Ethylenediamine 1-Naphthalenol, 4-methylbenzenesulfonate 1-Naphthylacetonitrile
ETHYLENE DIAMINE TOSYLATE ETHYLENEDIAMINE MONOHYDRATE 1-Naphthaleneacetic acid Monoethanolamine

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Preparation Products

N-(2-AMINOETHYL)-2-(1-NAPHTHYL)ACETAMIDE Naphazoline nitrate

Naphazoline Suppliers

Global( 101)Suppliers
Supplier Tel Email Country ProdList Advantage
CONIER CHEM AND PHARMA LIMITED 		+8618523575427 sales@conier.com China 47465 58
career henan chemical co 		+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
TargetMol Chemicals Inc. 		+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Hefei TNJ Chemical Industry Co.,Ltd. 		0551-65418671 sales@tnjchem.com China 34572 58
Dideu Industries Group Limited 		+86-29-89586680 +86-15129568250 1026@dideu.com China 29271 58
AFINE CHEMICALS LIMITED 		0571-85134551 info@afinechem.com CHINA 15377 58
Wuhan Fortuna Chemical Co., Ltd 		+86-27-59207850 +86-13986145403 info@fortunachem.com China 5988 58
Dayang Chem (Hangzhou) Co.,Ltd. 		571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
Zhejiang J&C Biological Technology Co.,Limited 		+1-2135480471 +1-2135480471 sales@sarms4muscle.com China 10523 58
Hubei Aumei New Material Co., Ltd. 		+86-027-87366298 +8615927270571 tianyi@skbiology.cn China 294 58
Supplier Advantage
CONIER CHEM AND PHARMA LIMITED 		58
career henan chemical co 		58
TargetMol Chemicals Inc. 		58
Hefei TNJ Chemical Industry Co.,Ltd. 		58
Dideu Industries Group Limited 		58
AFINE CHEMICALS LIMITED 		58
Wuhan Fortuna Chemical Co., Ltd 		58
Dayang Chem (Hangzhou) Co.,Ltd. 		58
Zhejiang J&C Biological Technology Co.,Limited 		58
Hubei Aumei New Material Co., Ltd. 		58

View Lastest Price from Naphazoline manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
Naphazoline pictures 2022-06-02 Naphazoline
835-31-4
 US $0.00-0.00 / kg 1kg 99% 1000kg WUHAN FORTUNA CHEMICAL CO., LTD
naphazoline pictures 2021-08-31 naphazoline
835-31-4
 US $50.00 / KG 1KG 99% 500tons/month Hubei Aumei New Material Co., Ltd.
Naphazoline USP/EP/BP pictures 2021-07-28 Naphazoline USP/EP/BP
835-31-4
 US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
  • Naphazoline pictures
  • Naphazoline
    835-31-4
  • US $0.00-0.00 / kg
  • 99%
  • WUHAN FORTUNA CHEMICAL CO., LTD
  • naphazoline pictures
  • naphazoline
    835-31-4
  • US $50.00 / KG
  • 99%
  • Hubei Aumei New Material Co., Ltd.

Naphazoline Spectrum

Naphazoline(835-31-4)1HNMR

835-31-4(Naphazoline)Related Search:

Dihydromyrcenol 2-Methylnaphthalene Tolazoline hydrochloride 1-Methylimidazole Oxymetazoline
Imidazole Oxymetazoline hydrochloride Naphazoline nitrate NAPHAZOLINE HCL,NAPHAZOLINE HYDROCHLORIDE,NAPHAZOLINE HYDROCHLORIDE EXTRA PURE PH EUR,BP,USP,Naphazoline·hydrochloric acid IMIDAZOLE HYDROCHLORIDE
NAPHAZOLINE HYDROCHLORIDE - REFERENCE SPECTRUM NAPHAZOLINE IMPURITY A Naphazoline NAPHAZOLINE HCL(USP)(COMING SOON)(P) NAPHAZOLINE HYDROCHLORIDE IMP. C (EP): (1-NAPHTHYL)ACETONITRILE MM(CRM STANDARD)
NAPHAZOLINE (BASE) Naphazoline HCL USP23 NAPHAZOLINE NITRATE REFERENCE SPECTRUM EPY(CRM STANDARD)

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4,5-DIHYDRO-2-(1-NAPHTHYLMETHYL)-1H-IMIDAZOLE HYDROCHLORIDE 2-(1-NAPHTHYLMETHYL)IMIDAZOLINIUM CHLORIDE 1H-Imidazole, 4,5-dihydro-2-(1-naphthalenylmethyl)- NAFAZOLINE 2-(Naphthalen-1-ylmethyl)-4,5-dihydro-1H-imidazole Naphazoline 2-(1-Naphtylmethyl)-2-imidazoline 2-(1-Naphtylmethyl)-4,5-dihydro-1H-imidazole 4,5-Dihydro-2-(1-naphtylmethyl)-1H-imidazole naphazoline:2-(naphthalen-1-ylmethyl)-4,5-dihydro-1h-IMIDAZOLE 2-(1-Naphethylmethyl)-2-imidazoline 2-(1-naphthylmethyl)-2-imidazolin 2-(1-Naphthylmethyl)-2-imidazoline 2-(1-Naphthylmethyl)-4,5-dihydro-1H-imidazole 2-(alpha-Naphthylmethyl)-imidazoline 2-(Naphthyl-(1')-methyl)imidazolin 2-(naphthyl-(1’)-methyl)imidazolin 2-Imidazoline, 2-(1-naphthylmethyl)- 4,5-dihydro-2-(1-naphthalenylmethyl)-1h-imidazol alpha-Naphthylmethyl imidazoline alpha-naphthylmethylimidazoline Antan CIBA 2020/r ciba2020/r Imidin Naphthizine Privine Rhinazine Sanorin 2-(1-naphthalenylmethyl)-4,5-dihydro-1H-imidazole Naphazoline USP/EP/BP Naphazoline DISCONTINUED. Please see N343955 or N343950 2-(1-NAPHTHYLMETHYL)-2-IMIDAZOLINE HYDROCHLORIDE Naphazoline-d4 NAPHAZOLINE HCL Inhibitor,TNFR,Adrenergic Receptor,Naphazoline,vascular hyperpermeability,Interleukin Related,decongestive,vasoconstriction,Tumor Necrosis Factor Receptor,cytokines,VEGFR,Vascular endothelial growth factor receptor,inflammation,inhibit,Naphthazoline,TNF Receptor,Beta Receptor,conjunctivitis 835-31-4 550-99-2835-31-4 C14H14N2HCl alpha-adrenoceptor agonist; imidazoline receptor agonist; vasoconstrictor. API