ALMOTRIPTAN
- CAS No.
- 181183-52-8
- Chemical Name:
- ALMOTRIPTAN
- Synonyms
- Axert;Almogran;PNU 180638;PNU-180638;Almotriptan;LAS-31416 Malate;1-[[[3-[2-(dimeth;Amotriptan malate;AlmotriptanMaleate;ALMOTRIPTAN MALATE
- CBNumber:
- CB2417037
- Molecular Formula:
- C21H31N3O7S
- Molecular Weight:
- 469.55
- MDL Number:
- MFCD08067740
- MOL File:
- 181183-52-8.mol
- MSDS File:
- SDS
| Melting point | 170-172°C |
|---|---|
| storage temp. | 2-8°C |
| solubility | Basic Alcohol (Very Slightly), DMSO (Slightly), Methanol (Slightly, Heated) |
| form | powder |
| color | white to beige |
| FDA UNII | PJP312605E |
SAFETY
Risk and Safety Statements
| Symbol(GHS) |  GHS07 |
|||||||||
|---|---|---|---|---|---|---|---|---|---|---|
| Signal word | Warning | |||||||||
| Hazard statements | H312-H332 | |||||||||
| Precautionary statements | P261-P271-P304+P340-P312-P280-P302+P352-P312-P322-P363-P501 | |||||||||
| HS Code | 2935904000 | |||||||||
| NFPA 704 |
|
ALMOTRIPTAN price More Price(36)
| Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
|---|---|---|---|---|---|---|---|
| Sigma-Aldrich | SML1210 | Almotriptan malate ≥98% (HPLC) | 181183-52-8 | 10MG | $138 | 2023-06-20 | Buy |
| Sigma-Aldrich | SML1210 | Almotriptan malate ≥98% (HPLC) | 181183-52-8 | 50MG | $547 | 2023-06-20 | Buy |
| Sigma-Aldrich | 1013512 | Almotriptan malate United States Pharmacopeia (USP) Reference Standard | 181183-52-8 | 200MG | $400 | 2022-05-15 | Buy |
| TCI Chemical | A3111 | Almotriptan Malate | 181183-52-8 | 25MG | $28 | 2024-03-01 | Buy |
| TCI Chemical | A3111 | Almotriptan Malate | 181183-52-8 | 100MG | $74 | 2024-03-01 | Buy |
ALMOTRIPTAN Chemical Properties,Uses,Production
Description
Almotriptan is a kind of triptan drug which can be used for the treatment of migraine headaches. It is belong to a drug category of selective serotonin receptor agonists. It has a high and specificity affinity for serotonin 5-HT receptors, further leading to vascoconstriction of the brain blood vessel and affecting the redistribution of blood flow. These effects stop pain signals from being sent to the brain, and further suppressing the release of certain natural substances which cause pain, nausea and other migraine symptoms. However, it doesn’t prevent migraine attacks.
References
https://en.wikipedia.org/wiki/Almotriptan
https://www.drugbank.ca/drugs/DB00918
Description
Almotriptan is an agonist of the serotonin (5-HT) receptor subtypes 5-HT1B and 5-HT1D (IC50s = 12 and 13 nM, respectively, in a radioligand binding assay). It is selective for human 5-HT1B and 5-HT1D receptors over rat 5-HT1A and human 5-HT2A and 5-HT4 receptors (IC50s = 0.85, 25.1, and 140 μM, respectively). Almotriptan induces contractions in isolated canine saphenous veins (EC50 = 394 nM) but not isolated rabbit renal or mesenteric arteries. It increases carotid vascular resistance in anesthetized cats (ED100 = 11 μg/kg, i.v.) without increasing blood pressure or heart rate. Formulations containing almotriptan have been used in the treatment of migraine headaches.
Chemical Properties
Pale Yellow Solid
Originator
Almogran ,Lundbeck
Uses
anti-migraine agent
Uses
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist; antimigraine.
Uses
Almotriptan is a serotonin 5HT1B /1D-receptor agonist used for treatment of migraine.
Definition
ChEBI: The malate salt of almotriptan.
Manufacturing Process
To a solution of previously dried 1-[[2-carboxy-3-(2-dimethylaminoethyl)-5-
indolyl]methanesulphonyl]-pyrrolidine (1.6 g; 0.0442 moles) in anhydrous
quinoline (75 ml) and under atmosphere of nitrogen, cuprous oxide (160 mg;
0.0011 moles) was added. The reaction mixture was heated to 190°C for 15
minutes, stirred to room temperature, poured into a mixture of 1 N
hydrochloric acid (150 ml) and ethyl acetate (50 ml), shaken and decanted.
The aqueous solution was washed several times with ethyl acetate, then solid
sodium bicarbonate was added until pH = 7.8, and washed with n-hexane to
eliminate the quinoline. The aqueous solution was made alkaline with solid
potassium carbonate and extracted with ethyl acetate. The organic solution
was dried (Na2SO4), the solvent removed under reduced pressure when a
dark oil was obtained (1.3 g; yield 92%). This product was purified by column
chromatography with silica gel and methylene chloride:ethanol:ammonium
hydroxide (60:8:1) as eluent and a white foam (0.8 g) of 1-[[3-(2-
dimethylaminoethyl)-5-indolyl]methanesulphonyl]-pyrrolidine was obtained. To
a solution of the above product (0.8 g) in acetone (30 ml), a few drops of
hydrogen chloride saturated dioxan solution, were added. The precipitated
solid was collected by filtration, washed with acetone and dried to give 1-[(3-
(2-(dimethylamino)ethyl)-5-indolyl)methanesulphonyl]-pyrrolidine
hydrochloride (0.75 g). Melting point 218°-220°C.
In practice it is usually used as malate salt.
brand name
Axert (Ortho-McNeil).
Therapeutic Function
Migraine therapy
General Description
Almotriptan, marketed in 2000, has the highest oralbioavailability among all triptans. It is metabolizedby both MAO-A and CYP3A4, thus has a more favorableside effects profile when compared with sumatriptan.However, it is only available in a 12.5 mg tablet form.
Biochem/physiol Actions
Almotriptan is a serotonin 5HT-1B/1D-receptor agonist used to treat migraine. Almotriptan has low nanomolar affinity for the 5-HT(1B) and 5-HT(1D) receptors while affinity for 5-HT receptors other than 5-HT(1B/1D) is substantially lower. Affinity for 5-HT(7) and 5-HT(1A) receptors was approximately 40 and 60 times lower than that for 5-HT(1B/1D) receptors, respectively.
ALMOTRIPTAN Preparation Products And Raw materials
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| Zibo Hangyu Biotechnology Development Co., Ltd | +86-0533-2185556 +8617865335152 | Mandy@hangyubiotech.com | China | 11013 | 58 |
| ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32480 | 60 |
| career henan chemical co | +86-0371-86658258 | sales@coreychem.com | China | 29914 | 58 |
| Hubei Jusheng Technology Co.,Ltd. | 18871490254 | linda@hubeijusheng.com | CHINA | 28180 | 58 |
| BOC Sciences | +1-631-485-4226 | inquiry@bocsci.com | United States | 19553 | 58 |
| Chongqing Chemdad Co., Ltd | +86-023-61398051 +8613650506873 | sales@chemdad.com | China | 39916 | 58 |
| CONIER CHEM AND PHARMA LIMITED | +8618523575427 | sales@conier.com | China | 47465 | 58 |
| SIMAGCHEM CORP | +86-13806087780 | sale@simagchem.com | China | 17367 | 58 |
| TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
| HANGZHOU CLAP TECHNOLOGY CO.,LTD | 86-571-88216897,88216896 13588875226 | sales@hzclap.com | CHINA | 6313 | 58 |
View Lastest Price from ALMOTRIPTAN manufacturers
| Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
|---|---|---|---|---|---|---|---|---|
 |
2024-01-02 | ALMOTRIPTAN
181183-52-8
|
US $70.00-700.00 / kg | 10kg | 0.99 | 20tons | Zibo Hangyu Biotechnology Development Co., Ltd | |
 |
2023-06-26 | Almotriptan
181183-52-8
|
US $200.00 / kg | 1kg | 99% | 1000kg/Month | Hebei Mingeng Biotechnology Co., Ltd | |
 |
2023-04-11 | Almotriptan
181183-52-8
|
US $100.00 / g | 25g | 99% | 1000g | Shijiazhuang Gantuo Biotechnology Co., Ltd |
-
- ALMOTRIPTAN
181183-52-8
- US $70.00-700.00 / kg
- 0.99
- Zibo Hangyu Biotechnology Development Co., Ltd
-
- Almotriptan
181183-52-8
- US $200.00 / kg
- 99%
- Hebei Mingeng Biotechnology Co., Ltd
-
- Almotriptan
181183-52-8
- US $100.00 / g
- 99%
- Shijiazhuang Gantuo Biotechnology Co., Ltd