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ALPHA-(-)-THUJONE

ALPHA-(-)-THUJONE structure

CAS No.: 546-80-5

Chemical Name:: ALPHA-(-)-THUJONE

Synonyms: α-Thujone;a-Thujone;Thujon;Nsc93742;l-Thujone;Tanacetone;thujan-3-one;(?)-α-Thujone;(-)-α-thujone;6-Ketosabinane

CBNumber:: CB2418953

Molecular Formula:: C10H16O

Molecular Weight:: 152.23

MDL Number:: MFCD00001313

MOL File:: 546-80-5.mol

MSDS File:: SDS

Last updated:2023-05-25 18:01:03

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ALPHA-(-)-THUJONE Properties

Melting point	181℃
alpha	D20 -19.2°
Boiling point	84-86 °C17 mm Hg(lit.)
Density	0.914 g/mL at 20 °C (lit.)
refractive index	n20/D 1.450
Flash point	148 °F
storage temp.	2-8°C
solubility	DMSO : 100 mg/mL (656.90 mM; Need ultrasonic)
form	Oil
color	Colourless
Odor	at 10.00 % in dipropylene glycol. cedarleaf thujonic
Odor Type	thujonic
optical activity	[α]20/D 19.0±2.0°, neat
BRN	4660369
LogP	2.044 (est)
CAS DataBase Reference	546-80-5
FDA UNII	R0SQ9G0DU5
EPA Substance Registry System	Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, (1S,4R,5R)- (546-80-5)

SAFETY

Risk and Safety Statements

Symbol(GHS)	GHS07
Signal word	Warning
Hazard statements	H302
Precautionary statements	P264-P270-P301+P312-P501
Hazard Codes	Xn
Risk Statements	22
Safety Statements	23-26-36/37/39-45
RIDADR	UN 2810 6.1/PG 3
WGK Germany	3
RTECS	XO9625000
F	23
HS Code	2914290090
Toxicity	LD50 s.c. in mice: 87.5 mg/kg (Rice, Wilson)

ALPHA-(-)-THUJONE price More Price(10)

Manufacturer	Product number	Product description	CAS number	Packaging	Price	Updated	Buy
Sigma-Aldrich	89231	(?)-α-Thujone ≥96.0% (GC)	546-80-5	1ml	$92.9	2024-03-01	Buy
Sigma-Aldrich	89231	(?)-α-Thujone ≥96.0% (GC)	546-80-5	5ml	$351	2024-03-01	Buy
TRC	T006230	α-Thujone	546-80-5	0.5ml	$130	2021-12-16	Buy
Apolloscientific	OR938655	(1S,4R,5R)-1-Isopropyl-4-methyl-bicyclo[3.1.0]hexan-3-one 95%	546-80-5	1g	$232	2021-12-16	Buy
Chem-Impex	41379	(1S,4R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one,96%(GC) 96%(GC)	546-80-5	5ML	$276.64	2021-12-16	Buy

Product number	Packaging	Price	Buy
89231	1ml	$92.9	Buy
89231	5ml	$351	Buy
T006230	0.5ml	$130	Buy
OR938655	1g	$232	Buy
41379	5ML	$276.64	Buy

ALPHA-(-)-THUJONE Chemical Properties,Uses,Production

Uses

α-Thujone is a GABA modulator and a genotoxic compound found in plants used in traditional medicines in developing countries.

Chemical Properties

Colorless liquid. Insoluble in water; soluble in alcohol. Combustible.

Uses

α-Thujone is a GABA modulator and a genotoxic compound found in plants used in traditional medicines in developing countries.

Uses

Solvent.

Definition

ChEBI: The (1S,4R,5R)-stereoisomer of alpha-thujone.

General Description

(-)-α-Thujone, a monoterpene ketone found in the essential oil of Thuja occidentalis, shows potent antitumorigenic effect.

Hazard

Toxic by ingestion.

Biochem/physiol Actions

GABAA receptor antagonist.

Safety Profile

Poison by intravenous, intraperitoneal, and subcutaneous routes. Moderately toxic by ingestion. Serious physiological consequences from abuse of absinthe (mainly in France) led to its abolition in 1915. Wormwood is still used in concentrations of less than 10 ppm in flavored wines. Thujone at 30 mg/kg causes convulsions associated with lesions of the cerebral cortex. Little is known of thujone metabolism. Both forms occur in wormwood oil, oak moss. The a form is major constituent of cedar leaf oil or oil of thuja, sage. The p form occurs in tansy, yarrow. When heated to decomposition it emits acrid smoke and irritating fumes.

ALPHA-(-)-THUJONE Preparation Products And Raw materials

Raw materials

Preparation Products

Bicyclo[3.1.0]hexan-3-one, 4-hydroxy-4-methyl-1-(1-methylethyl)-, (1S,4R,5S)- (9CI)

ALPHA-(-)-THUJONE Suppliers

Global( 76)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Chengdu Biopurify Phytochemicals Ltd.	+8618080483897	sales@biopurify.com	China	3424	58
Hubei Jusheng Technology Co.,Ltd.	18871490254	linda@hubeijusheng.com	CHINA	28180	58
Shaanxi Pioneer Biotech Co., Ltd .	+8613259417953	sales@pioneerbiotech.com	China	3000	58
Antai Fine Chemical Technology Co.,Limited	18503026267	info@antaichem.com	CHINA	9641	58
Zhengzhou Alfa Chemical Co.,Ltd	+8618530059196	sale04@alfachem.cn	China	12468	58
Shaanxi Didu New Materials Co. Ltd	+86-89586680 +86-13289823923	1026@dideu.com	China	9116	58
LEAP CHEM CO., LTD.	+86-852-30606658	market18@leapchem.com	China	24738	58
TargetMol Chemicals Inc.	+1-781-999-5354	support@targetmol.com	United States	19973	58
Shanghai Acmec Biochemical Technology Co., Ltd.	+undefined18621343501	product@acmec-e.com	China	33349	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58

Supplier	Advantage
Chengdu Biopurify Phytochemicals Ltd.	58
Hubei Jusheng Technology Co.,Ltd.	58
Shaanxi Pioneer Biotech Co., Ltd .	58
Antai Fine Chemical Technology Co.,Limited	58
Zhengzhou Alfa Chemical Co.,Ltd	58
Shaanxi Didu New Materials Co. Ltd	58
LEAP CHEM CO., LTD.	58
TargetMol Chemicals Inc.	58
Shanghai Acmec Biochemical Technology Co., Ltd.	58
Aladdin Scientific	58

View Lastest Price from ALPHA-(-)-THUJONE manufacturers

Image	Update time	Product	Price	Min. Order	Purity	Supply Ability	Manufacturer
	2021-07-02	()-α-Thujone 546-80-5	US $15.00-10.00 / KG	1KG	99%+ HPLC	Monthly supply of 1 ton	Zhuozhou Wenxi import and Export Co., Ltd

()-α-Thujone
546-80-5
US $15.00-10.00 / KG
99%+ HPLC
Zhuozhou Wenxi import and Export Co., Ltd

546-80-5(ALPHA-(-)-THUJONE)Related Search:

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1of4

(1s,4r,5r)-(-)-3-thujanon 3-Thujanone, (-)- 3-Thujanone, (1S,4R,5R)-(-)- 4-methyl-1-(1-methylethyl)-,[1S-(1.alpha.,4.alpha.,5.alpha.)]-Bicyclo[3.1.0]hexan-3-one 4-Methyl-1-(1-methylethyl)bicyclo[3.1.0]hexan-3-one 6-Ketosabinane THUJONE, ALPHA-(-)- (-)-ALPHA-THUJONE ALPHA-(-)-THUJONE (-)-3-Isothujone (-)-3-thujanon bicyclo(3.1.0)hexan-3-one,4-methyl-1-(1-methylethyl)-,(1s-1-alpha,4-alpha,5 Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, [1S-(1alpha,4alpha,5alpha)]- bicyclo[3.1.0]hexan-3-one,4-methyl-1-(1-methylethyl)-,[1s-(1alpha,4alpha,5 Isothujone, (-)- l-Thujone Tanacetone thujan-3-one Thujon [1S]-4-Methyl-1α-[1-methylethyl] bicyclo[3.1.0]hexan-3-one Bicyclo3.1.0hexan-3-one, 4-methyl-1-(1-methylethyl)-, (1S,4R,5R)- Bicyclo[3.1.0]hexan-3-one, 4-methyl-1-(1-methylethyl)-, [1S-(1α,4α,5α)]- A-(-)-THUJONE WITH GC Nsc93742 ()-α-Thujone,(1S,4R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one (1S,4R,5R)- 3-Thujanone (-)-alpha-Thujone >=96.0% (GC) (1S,4R)-1-ISOPROPYL-4-METHYLBICYCLO[3.1.0]HEXAN-3-ONE (1S,4R,5R)-4-METHYL-1-(PROPAN-2-YL)BICYCLO[3.1.0]HEXAN-3-ONE (?)-α-Thujone (-)-α-thujone α-Thujone a-Thujone pro-apoptotic,anti-invasive,α Thujone,Monoterpene,oxidative,antinociceptive,Gamma-aminobutyric acid Receptor,Apoptosis,Inhibitor,BBB,γ-Aminobutyric acid Receptor,inhibit,Reactive Oxygen Species,Autophagy,GABA Receptor,ROS,Parasite,αThujone,anthelmintic,anti-tumor,α-Thujone,insecticidal,stress (1S,4R,5R)-1-Isopropyl-4-methylbicyclo[3.1.0]hexan-3-one 546-80-5 Cell Signaling and Neuroscience C10 Cell Biology Carbonyl Compounds BioChemical Building Blocks GABA and Glycine Receptor Modulators Ketones Ion Channels Ligand-Gated Ion Channels Organic Building Blocks Organics