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Tegafur

Antineoplastic Chemical Properties Uses Production methods
Tegafur
Tegafur structure
CAS No.
17902-23-7
Chemical Name:
Tegafur
Synonyms
riol;lamar;lifril;FT-207;fulaid;FENTAL;EXONAL;neberk;Fluaid;fulfeel
CBNumber:
CB2419051
Molecular Formula:
C8H9FN2O3
Formula Weight:
200.17
MOL File:
17902-23-7.mol

Tegafur Properties

Melting point:
171-173 °C(lit.)
Density 
1.3222 (estimate)
storage temp. 
2-8°C
solubility 
DMSO: >50mg/mL
pka
7.63±0.10(Predicted)
form 
Very Fine Crystalline Powder
color 
white to off-white
Merck 
14,9112
InChIKey
WFWLQNSHRPWKFK-UHFFFAOYSA-N
CAS DataBase Reference
17902-23-7(CAS DataBase Reference)
NCI Dictionary of Cancer Terms
tegafur
FDA UNII
1548R74NSZ
EPA Substance Registry System
2,4(1H,3H)-Pyrimidinedione, 5-fluoro-1-(tetrahydro-2-furanyl)- (17902-23-7)
SAFETY
  • Risk and Safety Statements
Symbol(GHS) 
GHS06
Signal word  Danger
Hazard statements  H301-H311-H331
Precautionary statements  P261-P280-P301+P310-P311
Hazard Codes  T
Risk Statements  23/24/25
Safety Statements  22-36/37/39-45
RIDADR  UN 2811 6.1/PG 2
WGK Germany  3
RTECS  YR0450000
HazardClass  6.1
PackingGroup  II
HS Code  29349990
Toxicity LD50 in mice (mg/kg): 900 orally (3 days) (Yasumoto); 750 i.p. (FR 1574684), also reported as 1150 i.p. (Smart)
NFPA 704
0
1 0

Tegafur price More Price(7)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich T7205 Tegafur ≥98% (HPLC), powder 17902-23-7 5mg $76.2 2019-12-02 Buy
Sigma-Aldrich T7205 Tegafur ≥98% (HPLC), powder 17902-23-7 25mg $300 2019-12-02 Buy
TCI Chemical F0635 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil >98.0%(HPLC)(N) 17902-23-7 5g $83 2020-06-24 Buy
TCI Chemical F0635 5-Fluoro-1-(tetrahydro-2-furfuryl)uracil >98.0%(HPLC)(N) 17902-23-7 25g $207 2020-06-24 Buy
Cayman Chemical 26076 Tegafur ≥98% 17902-23-7 500mg $112 2020-06-24 Buy

Tegafur Chemical Properties,Uses,Production

Antineoplastic

Tegafur is a anticancer drug.it is a fluorouracil derivative, in vitro it has no anti-tumor effect, after it goes into the human body ,by the role of the liver drug metabolism enzymes and microsomal enzymes P-450 in the liver, its tetrahydrofuran ring is taken off, fluorouracil (5-FU)is gradually released to produce cytotoxicity. Variety of tumor inhibition is similar to 5-FU, its mechanism of inhibition is inhibiting thymidine synthetase, blocking deoxy thymidylate converting to pyrimidine nucleotide, thereby interfering and blocking the synthesis of DNA, RNA and protein .
Tegafur index of chemotherapy is twice of 5-FU and toxicity is 1/6~1/5 of 5-FU ,there is cross-resistance between 5-FU and the product,it belongs to cycle-specific drugs, tegafur belongs to the time-dependent cytostatic, preferable absorption after oral , Tmax is 2h, it slowly releases 5-FU in vivo, blood level is not very high, it can maintain a longer time, so it has a low toxicity in vivo.the Intravenous infusion is better than the one-time injection. After the drug going into the body, it is evenly distributed in the liver, small intestine, spleen, lung, kidney and brain, liver and kidney having the highest concentrations. T1/2 is 5~18.6h. Inhibition of DNA, RNA synthesis can maintain 12~20h. After 24h, the content of each tissue is significantly reduced. It is Mainly excreted in the urine and respiratory tract , within 24h after administration, 23% is by the urine excretion of the prototype , 55% is excreted from the respiratory tract in the form of CO2. This product is highly fat-soluble, widely distributed, easily through the blood-brain barrier, its cerebrospinal fluid concentration is higher than 5-FU.
This product is effective against a variety of solid tumors, it is primarily used for the treatment of digestive system cancers, tegafur has a effective rate of 30% to 33% on gastric cancer ,it has a certain effect on colon cancer, colorectal cancer, lung cancer, primary and metastatic liver cancer, pancreatic cancer , cholangiocarcinoma, gallbladder cancer, prostate cancer, kidney cancer, bladder cancer . It can also be used to treat breast cancer, head and neck squamous cell carcinoma, lung cancer and liver cancer. It is Also used as a radiation sensitizer before and after surgery treatment to prevent cancer recurrence, proliferation and metastasis. Overall, the efficacy of this product is a little better than 5-FU.
The above information is edited by the Chemicalbook of Tian Ye.

Chemical Properties

White crystalline powder. Melting point 164-165 ℃, soluble in water, ethanol, dimethylformamide, insoluble in ether, benzene. Odorless, bitter taste.

Uses

this product is a derivative of 5-fluorouracil, the role and application of the product is the same as 5-fluorouracil, but it has less toxicity and its chemotherapy index is high. After the activion by the liver in vivo ,it becomes 5-fluorouracil to play a role in cancer. It is effective on Gastric cancer, colon cancer, colorectal cancer, pancreatic cancer and breast cancer, lung cancer.

Production methods

After condensatio from 5-fluorouracil and 2-acetoxy tetrahydrofurann, the product is obtained. The yield rate of this method is only15%. Another method is using 5-fluorouracil, hexamethyl silazane and trimethylchlorosilane as starting materials to produce tegafur.

Chemical Properties

White Crystalline Powder

Uses

Used as an antineoplastic

Safety Profile

Poison by ingestion. Moderately toxic to humans by intravenous route. Moderately toxic experimentally by intraperitoneal, intravenous, and subcutaneous routes. Experimental teratogenic data. Human systemic effects: nausea and vomiting. Experimental reproductive effects. Questionable human carcinogen producing gastrointestinal tumors. Human mutation data reported. Used as an anti-cancer agent. When heated to decomposition it emits very toxic fumes of Fand NOx.

Tegafur Preparation Products And Raw materials

Raw materials

Preparation Products


Tegafur Suppliers

Global( 251)Suppliers
Supplier Tel Fax Email Country ProdList Advantage
Henan DaKen Chemical CO.,LTD.
+86-371-55531817
info@dakenchem.com CHINA 21838 58
Henan Tianfu Chemical Co.,Ltd.
0371-55170693
0371-55170693 info@tianfuchem.com CHINA 22625 55
career henan chemical co
+86-371-86658258
sales@coreychem.com CHINA 30043 58
Chemwill Asia Co.,Ltd.
86-21-51086038
86-21-51861608 chemwill_asia@126.com;sales@chemwill.com;chemwill@hotmail.com;chemwill@gmail.com CHINA 23977 58
Hubei Jusheng Technology Co.,Ltd.
86-18871470254
027-59599243 linda@hubeijusheng.com CHINA 28231 58
Hebei Jimi Trading Co., Ltd.
+86 319 5273535
bestoneforyou@sina.com CHINA 293 58
Haihang Industry Co.,Ltd
86-531-88032799
+86 531 8582 1093 export@haihangchem.com CHINA 10157 58
Xiamen AmoyChem Co., Ltd
+86 592-605 1114
sales@amoychem.com CHINA 6371 58
Hubei xin bonus chemical co. LTD
86-13657291602
027-59338440 linda@hubeijusheng.com CHINA 23045 58
Beijing Yibai Biotechnology Co., Ltd
0086-182-6772-3597
sales04@yibaibiotech.com CHINA 420 58

View Lastest Price from Tegafur manufacturers

Image Release date Product Price Min. Order Purity Supply Ability Manufacturer
2019-08-27 Tegafur
17902-23-7
US $0.00-0.00 / KG 1g 99.0% 500kg/month Beijing Yibai Biotechnology Co., Ltd
2020-04-29 Tegafur
17902-23-7
US $0.00-0.00 / 公斤 1KG 99.0%+ 800 tons Shaanxi Dideu Medichem Co. Ltd
2018-07-26 Tegafur
17902-23-7
US $100.00 / KG 1KG 98% 100KG career henan chemical co

Tegafur Spectrum


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