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NONACTIN

CAS No.
6833-84-7
Chemical Name:
NONACTIN
Synonyms
3584-a;a-5584;e-79-c;n-329-a;NONACTIN;ta-25-m-i;fh-3582-a;POLYNACTIN;WERRAMYCIN A;AMMONIUM IONOPHORE
CBNumber:
CB2424675
Molecular Formula:
C40H64O12
Molecular Weight:
736.93
MDL Number:
MFCD00043039
MOL File:
6833-84-7.mol
Last updated:2023-05-18 11:31:08

NONACTIN Properties

Melting point 147-148°
Boiling point 890.6±65.0 °C(Predicted)
Density 1.11-1.15 g/cm3
storage temp. 2-8°C
solubility chloroform: soluble10mg/mL
form White to off-white crystalline solid.
color white to faint yellow
Sensitive Moisture Sensitive
Merck 13,6709
BRN 76434
Stability Stable for 1 year from date of purchase as supplied. Solutions in DMSO or ethanol may be stored at -20° for up to 2 months.
EWG's Food Scores 1
FDA UNII TTP24WX8P7

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictograms
GHS07
Signal word  Warning
Hazard statements  H315-H319-H335
Precautionary statements  P261-P271-P280
Hazard Codes  Xi
Safety Statements  22-24/25
WGK Germany  3
RTECS  RH1685000
10-21
HS Code  29321900
Toxicity LD50 intravenous in mouse: 246mg/kg

NONACTIN price More Price(18)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich 09877 Ammonium ionophore I Selectophore 6833-84-7 50mg $389 2024-03-01 Buy
Sigma-Aldrich 09877 Ammonium ionophore I Selectophore 6833-84-7 250mg $1780 2024-03-01 Buy
Cayman Chemical 19468 Nonactin ≥95% 6833-84-7 5mg $49 2024-03-01 Buy
Cayman Chemical 19468 Nonactin ≥95% 6833-84-7 10mg $87 2024-03-01 Buy
Sigma-Aldrich N2286 Nonactin ≥98% (function tested, HPLC) 6833-84-7 10mg $188 2024-03-01 Buy
Product number Packaging Price Buy
09877 50mg $389 Buy
09877 250mg $1780 Buy
19468 5mg $49 Buy
19468 10mg $87 Buy
N2286 10mg $188 Buy

NONACTIN Chemical Properties,Uses,Production

Description

Nonactin (6833-84-7) is a monovalent cation ionophore with high selectivity for NH4+ and K+ .1 Upregulates levels of mitochondrial stress proteins HSP58 and GRP75.2 Nonactin abolishes mitochondrial membrane potential.3

Chemical Properties

Light yellow powder

Uses

Nonactin is the smallest member of the macrotetrolide complex produced by a range of Streptomyces species. Originally the name, nonactin, reflected the lack of biological activity. The literature is confusing in this respect, as virtually all sources of nonactin are contaminated with small amounts of the much more active monactin. The BioAustralis nonactin has been purified to remove traces of other biologically-active macrotetrolides. Like the other macrotetrolides, nonactin is a monovalent cation ionophore with high selectivity for ammonium and potassium.

Uses

Nonactin is an ionophore antiobiotic that selectively binds K+?and NH4+.

Definition

ChEBI: Nonactin is a macrotetrolide.

Biological Activity

Monovalent cation ionophore that displays selectivity for K + and NH 4 + (K + = NH 4 + > Na + > Mg 2+ > Li + >> Ca 2+ for nonactin-EVA sensor). Induces cation transport across artificial membranes. Also inhibits P-glycoprotein-mediated efflux of chemotherapeutic agents in multiple-drug resistant cancer cells. Antibiotic.

Purification Methods

This macrotetrolide antibiotic crystallises from MeOH as colourless needles and is dried at 90o/20hours/high vacuum. [Cordaz et al. Helv Chim Acta 38 1445 1955, crystal structure: Dobler Helv Chim Acta 55 1371 1972, Gambos et al. Tetrahedron Lett 3391 1975, Beilstein 19/12 V 751.]

References

1) Garcia et al. (2003), Determination of potassium ions in pharmaceutical samples by FIA using a potentiometric electrode based on ionophore nonactin occulded in EVA membrane; J. Pham. Biomed. Anal., 31 11 2) Mizzen et al. (1989), Identification, characterization and purification of two mammalian stress proteins present in mitochondria, grp 75, a member of the hsp 70 family and hsp 58, a homolog of the bacterial groEL protein; J. Biol. Chem., 264 20664 3) Dudani et al. (1990), Effects of antimitotic and antimitochondrial agents on the cellular distribution of microtubules and mitochondria; Cytobios, 63 95

NONACTIN Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 112)Suppliers
Supplier Tel Email Country ProdList Advantage
career henan chemical co
+86-0371-86658258 15093356674; factory@coreychem.com China 29826 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-81138252 +86-18789408387 1057@dideu.com China 3979 58
Shaanxi Dideu Medichem Co. Ltd
+86-029-89586680 +86-18192503167 1026@dideu.com China 9802 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
BOC Sciences
+16314854226 inquiry@bocsci.com United States 19743 58
GIHI CHEMICALS CO.,LIMITED
+8618058761490 info@gihichemicals.com China 50001 58
Shanghai Acmec Biochemical Technology Co., Ltd.
+undefined18621343501 product@acmec-e.com China 33349 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76
3B Pharmachem (Wuhan) International Co.,Ltd. 821-50328103-801 18930552037 3bsc@sina.com China 15848 69
Tianjin heowns Biochemical Technology Co., Ltd. 400 638 7771 sales@heowns.com China 14443 57

View Lastest Price from NONACTIN manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
NONACTIN USP/EP/BP pictures 2021-06-25 NONACTIN USP/EP/BP
6833-84-7
US $1.10 / g 1g 99.9% 100 Tons Min Dideu Industries Group Limited
Nonactin  pictures 2020-05-10 Nonactin
6833-84-7
US $1.00 / KG 1KG 99% 20T Shaanxi Dideu Medichem Co. Ltd
NONACTIN pictures 2019-12-26 NONACTIN
6833-84-7
US $1.00 / g 1g ≥98% g/kg/Ton Career Henan Chemical Co
  • Nonactin  pictures
  • Nonactin
    6833-84-7
  • US $1.00 / KG
  • 99%
  • Shaanxi Dideu Medichem Co. Ltd
  • NONACTIN pictures
  • NONACTIN
    6833-84-7
  • US $1.00 / g
  • ≥98%
  • Career Henan Chemical Co
ta-25-m-i NONACTIN NONACTIN, STREPTOMYCES GRISEUS POLYNACTIN NONACTIN FROM STREPTOMYCES GRISEUS NONACTINE, FROM STREPTOMYCES SP. NONACTIN FROM STREPTOMYCES TSUSIMAENSIS nonactinfromstreptomycessp. NONACTINE, STREPTOMYCES GRISEUS Nonactin, Amonium Ionophore, Werramycin A, Polynactin Ammonium ionophore, Nonactin (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)-2,5,11,14,20,23,29,32-Octamethyl-4,13,22,31,37,38,39,40-octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone WerraMycin, FH 3582A, NSC 52141, AKD 1A, KD 1A Nonactin / 5342 Pfw 19 / A 4426 / Ammonium ionophore I Nonactin from Streptomyces griseus var griseus AMMONIUM IONOPHORE AMMONIUM IONOPHORE I WERRAMYCIN A -(1r*,2r*,5r*,7r*,10s*,11s*,14s*,16s*,19r*,20r*,23r*,25r*,28s*,29s*,32s*,34s*) 28))tetracontane-3,12,21,30-tetrone,2,5,11,14,20,23,29,32-octamethyl-2(1r 3584-a 4,13,22,31,37,38,39,40-octaoxapentacyclo(32.2.1.1(sup7,10).1(sup16,19).1(sup a-5584 e-79-c fh-3582-a n-329-a 4,13,22,31,37,38,39,40-Octaoxapentacyclo[32.2.1.17,10.116,19.125,28]tetracontane-3,12,21,30-tetrone, 2,5,11,14,20,23,29,32-octamethyl-, (1R,2R,5R,7R,10S,11S,14S,16S,19R,20R,23R,25R,28S,29S,32S,34S)- NONACTIN USP/EP/BP Nonactin (Mixture contains Monactin and Dinactin) (Technical Grade) Nonactin, Monactin, and Dinactin Mixture 6833-84-7 C40H64O12 Antibiotics A to Z Antibiotics N-S Antibiotics Ionophores Potentiometric for ISE Ion Sensor Materials BioChemical Analytical Chromatography Product Catalog inhibitor