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PROCHLORPERAZINE MALEATE

CAS No.
84-02-6
Chemical Name:
PROCHLORPERAZINE MALEATE
Synonyms
PROCHLORPERAZINE DIMALEATE;emetiral;Vertigon;buccastem;pasotomin;nibromina;enedioate(1:2);meterazinmaleate;Einecs 201-511-3;stemetildimaleate
CBNumber:
CB2439552
Molecular Formula:
C28H32ClN3O8S
Molecular Weight:
606.09
MDL Number:
MFCD00069330
MOL File:
84-02-6.mol
MSDS File:
SDS
Last updated:2023-06-08 09:02:48

PROCHLORPERAZINE MALEATE Properties

Melting point 1750C
storage temp. 2-8°C
solubility Very slightly soluble in water and in ethanol (96 per cent).
pka pKa 8.1(H2O,t =24±1) (Uncertain)
color White
λmax 313nm(MeOH)(lit.)
Merck 14,7761
Stability Stable for 2 years as supplied. Solutions in DMSO may be stored at -20° for up to 3 months.
FDA UNII I1T8O1JTL6

SAFETY

Risk and Safety Statements

Symbol(GHS)  GHS hazard pictogramsGHS hazard pictograms
GHS07,GHS08
Signal word  Warning
Hazard statements  H302-H336-H361d-H362
Precautionary statements  P202-P260-P263-P264-P301+P312-P308+P313
Hazard Codes  Xn
Risk Statements  20/21/22
Safety Statements  36
WGK Germany  3
RTECS  SO3150000
HS Code  2934302300
Toxicity LD50 in mice (mg/kg): 400 s.c.; 120 i.p.; 90 i.v., 400 orally (Courvoisier)
NFPA 704
0
3 0

PROCHLORPERAZINE MALEATE price More Price(26)

Manufacturer Product number Product description CAS number Packaging Price Updated Buy
Sigma-Aldrich P9178 Prochlorperazine dimaleate salt 84-02-6 5g $68.2 2024-03-01 Buy
Sigma-Aldrich P3200000 Prochlorperazine maleate European Pharmacopoeia (EP) Reference Standard 84-02-6 P3200000 $218 2023-06-20 Buy
Sigma-Aldrich BP638 Prochlorperazine maleate British Pharmacopoeia (BP) Reference Standard 84-02-6 100MG $221 2023-06-20 Buy
Sigma-Aldrich PHR3114 Prochlorperazine Maleate pharmaceutical secondary standard, certified reference material 84-02-6 500MG $175 2022-05-15 Buy
Sigma-Aldrich 1566001 Prochlorperazine maleate United States Pharmacopeia (USP) Reference Standard 84-02-6 200MG $400 2022-05-15 Buy
Product number Packaging Price Buy
P9178 5g $68.2 Buy
P3200000 P3200000 $218 Buy
BP638 100MG $221 Buy
PHR3114 500MG $175 Buy
1566001 200MG $400 Buy

PROCHLORPERAZINE MALEATE Chemical Properties,Uses,Production

Description

Prochlorperazine maleate (84-02-6) inhibits dynamin and clathrin-mediated endocytosis (CME) with an IC50=5.8 μM for CME.1?Increases tumor cell antigen presentation enhancing the efficacy of anti-tumor mAbs.2?A clinically useful antipsychotic agent3?with antimigraine4?and antiemetic activity5.

Chemical Properties

Off-White Powder

Uses

Antiemetic;Dopamine antagonist

Uses

Antiemetic.

brand name

Compazine (GlaxoSmithKline).

General Description

Prochlorperazinemaleate, 2-chloro-10-[3-(4-methyl-1-piperazinyl)propyl]phenothiazinemaleate (Compazine), is in the piperazine subgroupof the phenothiazines, characterized by high-milligramantipsychotic potency, a high prevalence of EPS, and lowsedative and autonomic effects. Prochlorperazine is more potenton a milligram basis than its alkylamino counterpart,chlorpromazine. Because of the high prevalence of EPS, however,it is used mainly for its antiemetic effect, not for its antipsychoticeffect.

Biological Activity

D 2 receptor antagonist. Also interacts with 5-HT 3 and nAChR. Displays antipsychotic, antispasmodic, antiemetic and antinociceptive activity in vivo .

Biochem/physiol Actions

Phenothiazine antipsychotic; D2 dopamine receptor antagonist; antispasmodic

References

References/Citations 1) Daniel?et al.?(2015),?Phenothiazine-derived antipsychotic drugs inhibit dynamin and clathrin-mediated endocytosis; Traffic,?16?635 2) Chew?et al.?(2020),?Endocytosis Inhibition in Humans to Improve Responses to ADCC-Mediating Antibodies; Cell,?180?895 3) Hollister?et al.?(1969),?Clinical use of psychotherapeutic drugs: current status;?Clin. Pharmacol. Ther.,?10?170 4) Cook and Newberry (2018),?Emergency Department Use of Intravenous Prochlorperazine for Acute Migraine; Adv. Emerg. Nurs. J.,?40?148 5) Van den Berg?et al.?(1996),?The prophylactic antiemetic efficacy of prochlorperazine and ondansetron in nasal septal surgery: a randomized double-blind comparison; Anaesth. Intensive Care,?24?538

PROCHLORPERAZINE MALEATE Preparation Products And Raw materials

Raw materials

Preparation Products

Global( 145)Suppliers
Supplier Tel Email Country ProdList Advantage
Hangzhou FandaChem Co.,Ltd.
008657128800458; +8615858145714 fandachem@gmail.com China 9354 55
TargetMol Chemicals Inc.
+1-781-999-5354 +1-00000000000 marketing@targetmol.com United States 19892 58
Dideu Industries Group Limited
+86-29-89586680 +86-15129568250 1026@dideu.com China 29831 58
AFINE CHEMICALS LIMITED
0571-85134551 info@afinechem.com CHINA 15377 58
Finetech Industry Limited
+86-27-87465837 +8618971612321 info@finetechnology-ind.com China 9589 58
Dayang Chem (Hangzhou) Co.,Ltd.
571-88938639 +8617705817739 info@dycnchem.com CHINA 52867 58
InvivoChem
+1-708-310-1919 +1-13798911105 sales@invivochem.cn United States 6393 58
LEAP CHEM CO., LTD.
+86-852-30606658 market18@leapchem.com China 24738 58
PT CHEM GROUP LIMITED
+86-85511178 +86-85511178 peter68@ptchemgroup.com China 35453 58
J & K SCIENTIFIC LTD. 010-82848833 400-666-7788 jkinfo@jkchemical.com China 96815 76

View Lastest Price from PROCHLORPERAZINE MALEATE manufacturers

Image Update time Product Price Min. Order Purity Supply Ability Manufacturer
PROCHLORPERAZINE MALEATE USP/EP/BP pictures 2021-07-24 PROCHLORPERAZINE MALEATE USP/EP/BP
84-02-6
US $1.10 / g 1g 99.9% 100 Tons min Dideu Industries Group Limited
2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-phenothiazinmaleate(1:2) buccastem emetiral enedioate(1:2) meterazinmaleate nibromina pasotomin prochloroproazinehydrogenmaleate prochlorperazinebimaleate prochlorperazinehydrogenmaleate prochlorperazinudimaleat stemetildimaleate Prochloroperazine Dimaleate Prochlorperazine Dimaleate Also See: P755800 Vertigon Prochlorpromazine dimaleate 10H-Phenothiazine, 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-, (Z)-2-butenedioate (1:2) Einecs 201-511-3 2-Chloro-10-[3[(4-methyl-1-piperazinyl)propyl]-10H-phenothiazinedimaleate Prochlorperazine Maleate (200 mg) 10H-Phenothiazine, 2-chloro-10-3-(4-methyl-1-piperazinyl)propyl-, (2Z)-2-butenedioate (1:2) PROCHLORPERAZINEMALEATE,USP 2-chloro-10-(3-(4-Methylpiperazin-1-yl)propyl)-10H-phenothiazine PROCHLORPERAZINE DIMALEATE SALT PROCHLORPERAZINE MALEATE 2-chloro-10-(3-(1-methyl-4-piperazinyl)propyl)phenothiazine,dimaleate 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)-10h-phenothiazin(z)-2-but 2-chloro-10-(3-(4-methyl-1-piperazinyl)propyl)phenothiazinedimaleate Prochlorperazine Maleate RS Prochlorperazine maleate CRS 2-Chloro-10-[3-(4-methylpiperazin-1-yl)propyl]phenothiazine Dimaleate PROCHLORPERAZINE MALEATE USP/EP/BP Prochlorperazine dimaleate saltQ: What is Prochlorperazine dimaleate salt Q: What is the CAS Number of Prochlorperazine dimaleate salt Q: What is the storage condition of Prochlorperazine dimaleate salt Q: What are the applications of Prochlorperazine dimaleate salt Prochlorperazine Maleate (1566001) PROCHLORPERAZINE DIMALEATE PROCHLORPERAZINE HCL IP/BP/USP 84-02-6 1984-2-6 C20H24ClN3SC4H4O42 C28H32ClN3O8S C24H24ClN3S2C4H4O4 C20H24ClN3S2C4H4O4 Heterocyclic Compounds Heterocycles Intermediates & Fine Chemicals Pharmaceuticals Antagonists Dopaminergics Neurotransmitters