4'-CHLORO-3-METHOXYCINNAMANILIDE
- CAS No.
- 472981-92-3
- Chemical Name:
- 4'-CHLORO-3-METHOXYCINNAMANILIDE
- Synonyms
- SB 366791;SB366791, >98%;SB 366791;SB366791;4'-CHLORO-3-METHOXYCINNAMANILIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE;N-(3-METHOXYPHENYL)-4-CHLOROCINNAMIDE;4'-CHLORO-3-METHOXYCINNAMANILIDE(SB366791);3-(4-Chlorophenyl)-N-(3-methoxyphenyl)acrylamide;(E)-3-(4-CHLOROPHENYL)-N-(3-METHOXYPHENYL)ACRYLAMIDE;3-(4-Chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide
- CBNumber:
- CB2449409
- Molecular Formula:
- C16H14ClNO2
- Molecular Weight:
- 287.74
- MDL Number:
- MFCD01033818
- MOL File:
- 472981-92-3.mol
- MSDS File:
- SDS
Melting point | 165-167℃ |
---|---|
storage temp. | Sealed in dry,Room Temperature |
solubility | DMSO: 13 mg/mL, soluble |
form | solid |
color | off-white |
Stability | Stable for 1 year from date of purchase as supplied. Solutions in DMSO may be stored at -20°C for up to 3 months. |
FDA UNII | E8EY4M2N4H |
SAFETY
Risk and Safety Statements
Safety Statements | 22-24/25 |
---|---|
WGK Germany | 3 |
HS Code | 2924.29.7790 |
4'-CHLORO-3-METHOXYCINNAMANILIDE price More Price(35)
Manufacturer | Product number | Product description | CAS number | Packaging | Price | Updated | Buy |
---|---|---|---|---|---|---|---|
Sigma-Aldrich | S0441 | SB-366791 ≥98% (HPLC), powder | 472981-92-3 | 5mg | $206 | 2024-03-01 | Buy |
Sigma-Aldrich | S0441 | SB-366791 ≥98% (HPLC), powder | 472981-92-3 | 25mg | $814 | 2024-03-01 | Buy |
TCI Chemical | B5762 | SB-366791 | 472981-92-3 | 25MG | $147 | 2024-03-01 | Buy |
TCI Chemical | B5762 | SB-366791 | 472981-92-3 | 100MG | $402 | 2024-03-01 | Buy |
Alfa Aesar | J67312 | SB-366791, 99% | 472981-92-3 | 5mg | $101 | 2021-12-16 | Buy |
4'-CHLORO-3-METHOXYCINNAMANILIDE Chemical Properties,Uses,Production
Description
SB-366791 (472981-92-3) is a potent (IC50 = 0.7 μM) and selective TRPV1 blocker.1,2 Selective for TRPV1 in a panel of 47 different binding assays.
Uses
N-(4-Methoxyphenyl)-4-chlorocinnamamide is a novel, potent, and selective cinnamide TRPV1 antagonist. Also a useful tool to further study the biology of TRPV1.
Uses
SB-366791 has been used as a transient receptor potential cation channel subfamily V member 1 (TRPV1) antagonist:
- to infer the in vitro and in vivo pharmacology of (E)-3-(4-t-butylphenyl)-N-(2,3-dihydrobenzo[b][1,4]dioxin-6-yl)acrylamide (AMG 9810)
- to study its effects on sodium hydrogen sulfide (NaHS) or capsaicin-induced contractile activity
- to study the inhibitory potency of phoneutria toxin (PnTx3-5) (native and recombinant) on various responses mediated by transient receptor potential cation channel subfamily V member 1 (TRPV1)
Definition
ChEBI: 3-(4-chlorophenyl)-N-(3-methoxyphenyl)-2-propenamide is a member of cinnamamides and a secondary carboxamide.
Biological Activity
Potent, selective and competitive vanilloid TRPV1 (VR1) receptor antagonist (pA 2 = 7.71 at hVR1); antagonizes hTRPV1 receptors activated by agonists, noxious heat, but not protons. Displays selectivity over a wide range of receptors and systems including CB 1 and CB 2 receptors, voltage-gated Ca 2+ channels and the hyperpolarization-activated current (I h ). Also available as part of the Vanilloid TRPV1 Receptor Tocriset™ .
Biochem/physiol Actions
SB-366791 might exhibit analgesic properties on bone cancer-related pain behavior.
storage
Store at RT
References
1) Gunthorpe, et al., (2004) Identification and characterization of SB-366791, a potent and selective vanilloid receptor (VR1/TRPV1) antagonist; Neuropharmacology 46 133 2) Varga et al. (2005) Effects of the novel TRPV1 receptor antagonist SB366791 in vitro and in vivo in the rat; Neurosci. Lett.. 385 137
4'-CHLORO-3-METHOXYCINNAMANILIDE Preparation Products And Raw materials
Raw materials
Preparation Products
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
ATK CHEMICAL COMPANY LIMITED | +undefined-21-51877795 | ivan@atkchemical.com | China | 32836 | 60 |
SHANGHAI T&W PHARMACEUTICAL CO., LTD. | +86-021-61551413 +8618813727289 | contact@trustwe.com | China | 5738 | 58 |
Zhejiang J&C Biological Technology Co.,Limited | +1-2135480471 +1-2135480471 | sales@sarms4muscle.com | China | 10522 | 58 |
InvivoChem | +1-708-310-1919 +1-13798911105 | sales@invivochem.cn | United States | 6393 | 58 |
TargetMol Chemicals Inc. | +1-781-999-5354 | support@targetmol.com | United States | 19973 | 58 |
ShenZhen Trendseen Biological Technology Co.,Ltd. | 13417589054 | trendseenbio@gmail.com | China | 11681 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 57511 | 58 |
Wuhan Jingkang en Biomedical Technology Co., Ltd | +8613720134139 | orders@jknbiochem.com | China | 5225 | 58 |
Amadis Chemical Company Limited | 571-89925085 | sales@amadischem.com | China | 131980 | 58 |
3B Pharmachem (Wuhan) International Co.,Ltd. | 821-50328103-801 18930552037 | 3bsc@sina.com | China | 15848 | 69 |
View Lastest Price from 4'-CHLORO-3-METHOXYCINNAMANILIDE manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2021-01-06 | 4'-CHLORO-3-METHOXYCINNAMANILIDE
472981-92-3
|
US $1.00 / g | 1g | 85.0-99.8% | 20tons | Career Henan Chemica Co |
- 4'-CHLORO-3-METHOXYCINNAMANILIDE
472981-92-3
- US $1.00 / g
- 85.0-99.8%
- Career Henan Chemica Co
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