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YAP-TEAD Inhibitor 1

YAP-TEAD Inhibitor 1 structure

CAS No.: 1659305-78-8

Chemical Name:: YAP-TEAD Inhibitor 1

Synonyms: YAP-TEAD-IN-1;Y413924] YAP-TEAD;YAP-TEAD Inhibitor 1;L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide

CBNumber:: CB24656621

Molecular Formula:: C93H144ClN23O21S2

Molecular Weight:: 2019.86

MDL Number:: MFCD32706886

MOL File:: 1659305-78-8.mol

Last updated:2023-05-21 10:59:17

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YAP-TEAD Inhibitor 1 Properties

Density	1.45±0.1 g/cm3(Predicted)
storage temp.	Store at -20°C
pka	4.45±0.10(Predicted)
Water Solubility	Water: 40 mg/mL (19.80 mM);

YAP-TEAD Inhibitor 1 Chemical Properties,Uses,Production

Biological Activity

YAP-TEAD Inhibitor 1 (Peptide 17) is a YAP-TEAD protein-protein interaction inhibitor which has potential usage in treatment of YAP-involved cancers with IC50 of 25 nM. The engineered peptide significantly improves the potency in disrupting YAP-TEAD interaction in vitro[1]. This 17mer peptide demonstrates a single-digit micromolar affinity to TEAD1[2].

References

[1] Zhang Z, et al. ACS Med Chem Lett. 2014, 5(9):993-998. [2] Zhou Z, et al. FASEB J. 2015, 29(2):724-732.

YAP-TEAD Inhibitor 1 Preparation Products And Raw materials

Raw materials

Preparation Products

YAP-TEAD Inhibitor 1 Suppliers

Global( 25)Suppliers

Supplier	Tel	Email	Country	ProdList	Advantage
Shenzhen Nexconn Pharmatechs Ltd	+86-755-89396905 +86-15013857715	admin@nexconn.com	China	10248	58
BOC Sciences	+1-631-485-4226	inquiry@bocsci.com	United States	19553	58
Shanghai Longyu Biotechnology Co., Ltd.	+8615821988213	info@longyupharma.com	China	2531	58
Career Henan Chemica Co	+86-0371-86658258 15093356674;	laboratory@coreychem.com	China	30255	58
Zhejiang J&C Biological Technology Co.,Limited	+1-2135480471 +1-2135480471	sales@sarms4muscle.com	China	10523	58
Hebei Miaoyin Technology Co.,Ltd	+86-17367732028 +86-17367732028	kathy@hbyinsheng.com	China	3582	58
Aladdin Scientific	+1-833-552-7181	sales@aladdinsci.com	United States	57511	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	18149758185	sales-cpd@caerulumpharma.com	China	3421	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	0510-85629785 18013409632	sales@reading-chemicals.com	China	15185	58
Shanghai Chaolan Chemical Technology Center	QQ:65489617 15618227136	info@SuperLan-chem.com	China	9445	58

Supplier	Advantage
Shenzhen Nexconn Pharmatechs Ltd	58
BOC Sciences	58
Shanghai Longyu Biotechnology Co., Ltd.	58
Career Henan Chemica Co	58
Zhejiang J&C Biological Technology Co.,Limited	58
Hebei Miaoyin Technology Co.,Ltd	58
Aladdin Scientific	58
ShangHai Caerulum Pharma Discovery Co., Ltd.	58
Wuxi Zhongkun Biochemical Technology Co., Ltd.	58
Shanghai Chaolan Chemical Technology Center	58

YAP-TEAD Inhibitor 1 YAP-TEAD-IN-1 L-α-Glutamine, N-acetyl-L-valyl-L-prolyl-3-chloro-L-phenylalanyl-L-homocysteinyl-L-leucyl-L-arginyl-L-lysyl-L-norleucyl-L-prolyl-L-alanyl-L-seryl-L-phenylalanyl-L-cysteinyl-L-lysyl-L-prolyl-L-prolyl-, cyclic (4→13)-disulfide Y413924] YAP-TEAD 1659305-78-8 C93H144ClN23O21S2