Compound 919278
- CAS No.
- 2189366-77-4
- Chemical Name:
- Compound 919278
- Synonyms
- LTβR-IN-1;Compound 919278;LTβR IN 1,LTβRIN1;LTβR-IN-1, 10 mM in DMSO;2H-Isoindole-2-acetamide, N-1H-benzimidazol-2-yl-1,3-dihydro-α-methyl-1-oxo-, (αR)-
- CBNumber:
- CB24667777
- Molecular Formula:
- C18H16N4O2
- Molecular Weight:
- 320.35
- MDL Number:
- MFCD32201063
- MOL File:
- 2189366-77-4.mol
Compound 919278 Chemical Properties,Uses,Production
Uses
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor. LTβR-IN-1 also selectively inhibits the nuclear translocation of p52 depended on TNF12A, instead of the nuclear translocation of p65 mediated by TNF-α receptor. LTβR-IN-1 regulates the NF-kB signaling pathway IN a ligand-independent manner[1].
Biological Activity
LTβR-IN-1 is a potent, selective lymphotoxin β receptor (LTβR) inhibitor with an IC50 of 10 μM. LTβR-IN-1 is potent in TWEAK-stimulated p52 translocation assays with an IC50 of 10 μM and did not alter TNF-α-induced p65 nuclear translocation[1].
References
[1]. Henry KL, et al. CDK12-mediated transcriptional regulation of noncanonical NF-κB components is essential for signaling. Sci Signal. 2018 Jul 31;11(541).
Compound 919278 Preparation Products And Raw materials
Raw materials
Preparation Products
Compound 919278 Suppliers
| Supplier | Tel | Country | ProdList | Advantage | |
|---|---|---|---|---|---|
| TargetMol Chemicals Inc. | +17819995354 | marketing@targetmol.com | United States | 32301 | 58 |
| Aladdin Scientific | tp@aladdinsci.com | United States | 52924 | 58 | |
| InvivoChem | 13549236410 | sales@invivochem.cn | China | 6753 | 58 |
| TargetMol Chemicals Inc. | 4008200310 | marketing@tsbiochem.com | China | 24972 | 58 |
| Suzhou Zhixin Biotechnology Co., Ltd. | 0512-65118909 15162312715 | sales@szzxbio.com | China | 2967 | 58 |
| Shanghai Yifei Biotechnology Co. , Ltd. | 021-65675885 18964387627 | customer_service@efebio.com | China | 11973 | 58 |
| RD International Technology Co., Limited | 18024082417 | market@ubiochem.com | China | 9835 | 58 |
| Sangon Biotech (Shanghai) Co.,Ltd. | 400-821-026 | Sales@sangon.com | China | 6710 | 58 |
| Biosynth Biological Technology (Suzhou) Co Ltd | 51288865780 | sales@biosynth.com | China | 6051 | 58 |
| Adooq Bioscience LLC | 400-025-6535 | sales@adooq.cn | China | 6215 | 58 |