E3 ligase Ligand-Linker Conjugates 12
- CAS No.
- 1797406-80-4
- Chemical Name:
- E3 ligase Ligand-Linker Conjugates 12
- Synonyms
- VH032-PEG3-N3;(S,R,S)-AHPC-PEG?-azide;(S,R,S)-AHPC-PEG3-azide;VHL Ligand-Linker Conjugates 8;E3 ligase Ligand-Linker Conjugates 12;(S,R,S) AHPC PEG3 N3,(S,R,S)-AHPC-PEG-3-N3,Inhibitor,inhibit,E3 Ligase Ligand-Linker Conjugates,(S,R,S)AHPCPEG3N3;L-Prolinamide, N-[2-[2-[2-(2-azidoethoxy)ethoxy]ethoxy]acetyl]-3-methyl-L-valyl-4-hydroxy-N-[[4-(4-methyl-5-thiazolyl)phenyl]methyl]-, (4R)-;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide;(2S,4R)-1-((S)-14-azido-2-(tert-butyl)-4-oxo-6,9,12-trioxa-3-azatetradecanoyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide, Crosslinker?E3 Ligase ligand conjugate, Protein degrader building block for PROTAC? research, Template for synthesis of targeted protein degrader, VH032 conjugate
- CBNumber:
- CB24694700
- Molecular Formula:
- C30H43N7O7S
- Molecular Weight:
- 645.78
- MDL Number:
- MFCD31807299
- MOL File:
- 1797406-80-4.mol
E3 ligase Ligand-Linker Conjugates 12 price More Price(2)
E3 ligase Ligand-Linker Conjugates 12 Chemical Properties,Uses,Production
Uses
Protein degrader builiding block (S,R,S)-AHPC-PEG3-Azide enables the synthesis of molecules for targeted protein degradation and PROTAC (proteolysis-targeting chimeras) technology. This conjugate contains a von Hippel-Lindau (VHL)-recruiting ligand and a PEGylated crosslinker with pendant azide for click chemistry with a target ligand. Because even slight alterations in ligands and crosslinkers can affect ternary complex formation between the target, E3 ligase, and PROTAC, many analogs are prepared to screen for optimal target degradation. When used with other protein degrader building blocks with a pendant azide group, parallel synthesis can be used to more quickly generate PROTAC libraries that feature variation in crosslinker length, composition, and E3 ligase ligand.
E3 ligase Ligand-Linker Conjugates 12 Preparation Products And Raw materials
Raw materials
Preparation Products
E3 ligase Ligand-Linker Conjugates 12 Suppliers
Supplier | Tel | Country | ProdList | Advantage | |
---|---|---|---|---|---|
TargetMol Chemicals Inc. | +1-781-999-5354 +1-00000000000 | marketing@targetmol.com | United States | 19892 | 58 |
Xian confluore Biological Technology Co., Ltd. | +86-15680926068 +86-15680926068 | 1924344760@confluore.cn | China | 2996 | 58 |
Aladdin Scientific | +1-+1(833)-552-7181 | sales@aladdinsci.com | United States | 52927 | 58 |
Sigma-Aldrich | 021-61415566 800-8193336 | orderCN@merckgroup.com | China | 51471 | 80 |
Shanghai Chaolan Chemical Technology Center | QQ:65489617 15618227136 | info@SuperLan-chem.com | China | 9943 | 58 |
Xi'an Confluore Biological Technology Co., Ltd. | +86-156-80926068 +86-15680926068 | 1924344760@qq.com | China | 4824 | 58 |
Jilin Province Woda Biotechnology Co., Ltd. | 13504435624 | 1927928688@qq.com | China | 1385 | 58 |
ChemeGen(Shanghai) Biotechnology Co.,Ltd. | 18818260767 | sales@chemegen.com | China | 11289 | 58 |
Shanghai Kaiwei Chemical Technology Co., Ltd. | 021-58461859 15821823057 | service@aiviche.com | China | 49323 | 58 |
Shanghai hongqu biomedical technology co. LTD | 88888888888 | hongquchem@qq.com | China | 5132 | 58 |
View Lastest Price from E3 ligase Ligand-Linker Conjugates 12 manufacturers
Image | Update time | Product | Price | Min. Order | Purity | Supply Ability | Manufacturer | |
---|---|---|---|---|---|---|---|---|
2024-04-02 | (S,R,S)-AHPC-PEG3-azide
1797406-80-4
|
US $0.00 / mg | 100mg | >99.00% | 100mg | Xian confluore Biological Technology Co., Ltd. |
- (S,R,S)-AHPC-PEG3-azide
1797406-80-4
- US $0.00 / mg
- >99.00%
- Xian confluore Biological Technology Co., Ltd.